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anti-Human CDCA8 Antibodies:
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Human Polyclonal CDCA8 Primary Antibody for WB - ABIN541375
Gassmann, Carvalho, Henzing, Ruchaud, Hudson, Honda, Nigg, Gerloff, Earnshaw: Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. in The Journal of cell biology 2004
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Human Polyclonal CDCA8 Primary Antibody for IHC (p), ELISA - ABIN544056
Xia, Canovas, Guadagno, Altieri: A survivin-ran complex regulates spindle formation in tumor cells. in Molecular and cellular biology 2008
Show all 2 Pubmed References
Human Polyclonal CDCA8 Primary Antibody for FACS, IHC (p) - ABIN388225
Sampath, Ohi, Leismann, Salic, Pozniakovski, Funabiki: The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. in Cell 2004
Show all 3 Pubmed References
Results show that CDCA8 is overexpressed in bladder cancer (BC) and its high levels are correlated with poor clinicopathological features of BC patients. Therefore, CDCA8 may act as a novel prognostic marker in the diagnosis of patients with BC.
These results were well correlated with the same gene expression pattern analysed in the thyroid tissue of the patient with BOREALIN-p.R114W. These studies open new avenues in the genetics of TD in humans.
Borealin dimerization mediates chromosomal passenger complex checkpoint function by enhancing localization to centromeres and kinetochores.
enhanced CDCA8 promoter activities by NF-Y overexpression and reduced CDCA8 transcription by NF-Y knockdown further verified that NF-Y is a positive regulator of CDCA8 transcription.
In colorectal cancer patients, Borealin expression was positively correlated with age, lymph node metastasis and neoplasm staging.
These findings reveal a previously unrecognized but direct link between HP1 and CPC localization in the centromere and illustrate the critical role of borealin-HP1 interaction in orchestrating an accurate cell division.
Borealin interacts directly with the Snf7 components of ESCRT-III in human cells.the Borealin central region encompassing residues 110-207 was both necessary & sufficient to bind to CHMP4C.
MLL5 functionally interacts with Borealin, facilitates the expression of chromosomal passenger complex, and hence contributes to mitotic fidelity and genomic integrity.
important role for phosphorylation of Borealin at S219 in the proper progression through mitosis
Data show that INCENP has an important role in stabilizing the chromosomal passenger complex, and that Borealin acts to promote binding of Survivin to INCENP.
Cell cycle-regulated chromosomal passenger protein whose aberrant expression and nuclear accumulation are linked to poor prognosis for gastric cancer.
A functional module within the chromosomal passenger complex involving the inner centromere protein INCENP, Survivin, and Borealin.
Borealin is phosphorylated during mitosis. Neither residue S165, T106 nor phosphorylation of borealin by Aurora B Kinase is required to generate the mitotic, shifted form of Borealin.
Suppression of CDCA8 expression with small interfering RNA against CDCA8 significantly suppressed the growth of lung cancer cells.
It is recorded that borealin is a cell cycle regulator, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues.
mitotic regulator Survivin binds as a monomer to its functional interactor Borealin
Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle.
Borealin plays a crucial role in the early mouse embryonic development
Data describe a mitotic SUMO2/3 conjugation-deconjugation cycle of Borealin and further assign a regulatory function of RanBP2 and SENP3 in the mitotic SUMO pathway.
found that substitutions at Borealin T230, recently identified as an Mps1 phosphorylation site, can modulate the dimerization state of Borealin
Borr interacts and colocalizes with the ESCRT-III component Shrb in Drosophila cells.
These findings indicate that Borealin plays a key role in liver development, regeneration, and tumorigenesis and suggests that Borealin could be a potential target for related liver diseases.
Borealin/DasraB is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16.
, cell division cycle-associated protein 8
, pluripotent embryonic stem cell-related gene 3 protein
, Cell division cycle-associated protein 8
, embryonic stem cell-related
, chromosomal passenger complex protein Dasra B
, cell division cycle associated 8