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anti-Human SMAD2 Antibodies:
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Human Polyclonal SMAD2 Primary Antibody for WB - ABIN2801941
Liu, Pouponnot, Massagué: Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. in Genes & development 1998
Show all 3 Pubmed References
Human Monoclonal SMAD2 Primary Antibody for ICC, FACS - ABIN969401
Wendt, Smith, Schiemann: p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. in The Journal of biological chemistry 2009
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Human Polyclonal SMAD2 Primary Antibody for WB - ABIN362416
Kim, Jong, Kim, Lee, Kim, Hong, Bang: Transforming growth factor-beta 1 induces apoptosis through Fas ligand-independent activation of the Fas death pathway in human gastric SNU-620 carcinoma cells. in Molecular biology of the cell 2004
Show all 2 Pubmed References
Human Polyclonal SMAD2 Primary Antibody for WB - ABIN362418
Zhang, Shen, Zhang, Wan, Yao, Wu, Wang, Chen, Yan, Jiang: Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice. in PLoS ONE 2013
Show all 2 Pubmed References
Human Polyclonal SMAD2 Primary Antibody for IHC (p), IHC - ABIN316295
Lee, Lee, Bae, Jung: Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3. in Histochemistry and cell biology 2013
Human Monoclonal SMAD2 Primary Antibody for IF, IHC (p) - ABIN517619
Talvinen, Tuikkala, Nykänen, Nieminen, Anttinen, Nevalainen, Hurme, Kuopio, Kronqvist: Altered expression of p120catenin predicts poor outcome in invasive breast cancer. in Journal of cancer research and clinical oncology 2010
Human Polyclonal SMAD2 Primary Antibody for WB - ABIN1842518
Song, Thalacker, Nilsen-Hamilton: Synergistic and multidimensional regulation of plasminogen activator inhibitor type 1 expression by transforming growth factor type ? and epidermal growth factor. in The Journal of biological chemistry 2012
Human Polyclonal SMAD2 Primary Antibody for ELISA, WB - ABIN257079
Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. in Cell 1996
Human Monoclonal SMAD2 Primary Antibody for FACS, IF - ABIN967045
Hannan, Jamshidi, Pera, Wolvetang: BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures. in Cloning and stem cells 2009
Show all 2 Pubmed References
Chicken Polyclonal SMAD2 Primary Antibody for IHC (p), WB - ABIN4354661
Xu, Xue, Li, Bi, Cao: Marek's disease virus type 1 microRNA miR-M3 suppresses cisplatin-induced apoptosis by targeting Smad2 of the transforming growth factor beta signal pathway. in Journal of virology 2010
the results of the present study indicated that miR4865p was upregulated in Osteoarthritis and may inhibit chondrocyte proliferation and migration by suppressing SMAD2.
relevance of the discovered Sirt1 (show SIRT1 Antibodies)-Smad2 interaction for the regulation of TGFbeta (show TGFB1 Antibodies)-dependent gene transcription
Our present study indicated that S100A11 (show S100A11 Antibodies) promotes EMT (show ITK Antibodies) through accumulation of TGF-beta1 (show TGFB1 Antibodies) expression, and TGF-beta1 (show TGFB1 Antibodies)-induced upregulation of p-SMAD2 and 3.
Compared with the control, miR (show MLXIP Antibodies)-340 was significantly lower in the serum of hepatocellular carcinoma patients (p<0.01). miR (show MLXIP Antibodies)-340 was lower in HCC (show FAM126A Antibodies) tissues than in adjacent; however, DcR3 (show TNFRSF6B Antibodies), TGF-beta1 (show TGFB1 Antibodies) and Smad2 were higher.
the results of the present study indicated that miR2145p may promote the adipogenic differentiation of BMSCs through regulation of the TGFbeta (show TGFB1 Antibodies)/Smad2/COL4A1 (show COL4A1 Antibodies) signaling pathway, and potentially may be used to develop a novel drug for postmenopausal osteoporosis.
High SMAD2 expression is associated with fibrosis in chronic pancreatitis and pancreatic cancer.
The results suggest that co-expression of active SMAD2/3 could enhance multiple types of transcription factors (TF)-based cell identity conversion and therefore be a powerful tool for cellular engineering.
We found that ITZ treatment was efficient in suppressing EMT (show ITK Antibodies) and that the effect of ITZ was partially mediated by impaired TGF-b/SMAD2/3 signaling. The role of TGF-b/SMAD2/3 signaling in mediating the effect of ITZ was confirmed based on the results that recombinant TGF-b induced, but the TGF-b neutralizing antibody inhibited EMT (show ITK Antibodies) as well as the invasion and migration of pancreatic cancer cells
SMAD2/3 interactome reveals that TGFbeta (show TGFB1 Antibodies) controls m(6)A mRNA methylation in pluripotency
This study's findings provide new insights into the mechanisms of how oscillatory shear stress regulates Smad2 signaling and pro-inflammatory genes through the complex signaling networks of integrins, transforming growth factor-beta receptors, and extracellular matrices, thus illustrating the molecular basis of regional pro-inflammatory activation within disturbed flow regions in the arterial tree.
the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (show TGFB1 Antibodies) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).
Activin A (show INHBA Antibodies) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (show NANOG Antibodies) and OCT4 (show POU5F1 Antibodies),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (show NANOG Antibodies)/OCT4 (show POU5F1 Antibodies) expression.
The non-Smad (show SMAD1 Antibodies) JNK (show MAPK8 Antibodies) signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad (show SMAD1 Antibodies) pathway, and this nuclear movement is associated with Smad (show SMAD1 Antibodies) signal transduction toward the nucleus.
The results of this study found that Bptf (show BPTF Antibodies) and TGF-beta (show TGFB1 Antibodies)/Smad2 mediate nucleosome remodeling to regulate wnt8a (show WNT8A Antibodies) expression and hence neural posteriorization.
Smad2 and Eomesodermin (show EOMES Antibodies) a (Eomesa (show EOMES Antibodies)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (show EOMES Antibodies) forms a general component of the Smad2 signalling complex in zebrafish.
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis
Grg4 (show TLE4 Antibodies) occupancy at the Xnr1 (show NODAL Antibodies) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 (show TLE4 Antibodies) from FoxH1 (show FOXH1 Antibodies) at the Xnr1 (show NODAL Antibodies) enhancer, an essential feature of the transcriptional switch mechanism.
E2a (show TCF3 Antibodies) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
GDF11 (show GDF11 Antibodies) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.
The expression of Toll (show TLR4 Antibodies)-like receptor (TLR)4 (show TLR4 Antibodies) and NF-kappaB p50 (show NFKB1 Antibodies) was also inhibited by Andro. Additionally, in vitro data confirmed that Andro treatment not only attenuated the expression of profibrotic and proinflammatory factors but also blocked the TGF-beta1 (show TGFB1 Antibodies)/Smad2 and TLR4 (show TLR4 Antibodies)/NF-kappaB p50 (show NFKB1 Antibodies) pathways.
both ERK (show EPHB2 Antibodies) and Smad2 signal pathways are involved in the activation of macrophages induced by TGF-b1 and high-ambient glucose, while there is no crosstalk shown in the process.
Activin (show Actbeta Antibodies) signaling through SMAD2/3 in retinal progenitor cells regulates expression of transcription factors involved in cell type determination and promotes photoreceptor lineage specification.
Kidney samples from patients with advanced stages of diabetic nephropathy showed elevated pSmad2 staining whereas db/db (show LEPR Antibodies) mouse kidneys surprisingly showed a decrease in pSmad2 in the tubular compartment. These results indicate a lack of translation from type 2 diabetes patient kidneys to the db/db (show LEPR Antibodies) model with regards to Smad (show SMAD1 Antibodies) signaling pathway.
Results suggest that Smad2/3 linker threonine phosphorylation is expressed during acinar-ductal metaplasia.
NODAL/Activin (show Actbeta Antibodies) signaling induces dramatic chromatin landscape changes, and a dynamic transcriptional network regulated by SMAD2, acting via multiple mechanisms.
Blocking Smad2/3 signaling in pluripotent stem cells results in epigenetic changes that enhance the capacity for endoderm differentiation.
cells expressing mutant huntingtin (show HTT Antibodies) have a dysregulated transcriptional response to epidermal growth factor (show EGF Antibodies) stimulation
Smad2- and Smad3 (show SMAD3 Antibodies)-deficient bone marrow (BM) cells display reduced sensitivity to transforming growth factor-beta (TGFbeta (show TGFB1 Antibodies)) inhibition.
Data (including data from studies using knockout mice) suggest Garp/Lrrc32 (show LRRC32 Antibodies) is involved in up-regulation of Tgfb3 (show TGFB3 Antibodies) and is essential for embryogenesis of palate; Garp (show LRRC32 Antibodies) knockout causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Garp (show LRRC32 Antibodies) = glycoprotein A repetitions predominant (show LRRC32 Antibodies) protein; Tgfb3 (show TGFB3 Antibodies) = transforming growth factor beta 3 (show TGFB3 Antibodies))
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
MAD homolog 2
, SMAD, mothers against DPP homolog 2
, Sma- and Mad-related protein 2
, mother against DPP homolog 2
, mothers against decapentaplegic homolog 2
, SMAD 2
, mothers against DPP homolog 2
, mothers against decapentaplegic-like 2
, MAD (mothers against decapentaplegic, Drosophila) homolog 2
, SMA- and MAD-related protein 2
, SMAD family member 2
, Smad 2
, mad-related protein 2
, LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 2