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anti-Mouse (Murine) PDE4D Antibodies:
anti-Human PDE4D Antibodies:
anti-Rat (Rattus) PDE4D Antibodies:
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Human Polyclonal PDE4D Primary Antibody for CM, ICC - ABIN2747152
Farooqui, Al-Bagdadi, Houslay, Bolger, Stout, Specian, Cherry, Conti, ODonnell: Surgically induced cryptorchidism-related degenerative changes in spermatogonia are associated with loss of cyclic adenosine monophosphate-dependent phosphodiesterases type 4 in abdominal testes of rats. in Biology of reproduction 2001
Show all 25 Pubmed References
Human Polyclonal PDE4D Primary Antibody for ELISA, WB - ABIN185530
Houslay: The long and short of vascular smooth muscle phosphodiesterase-4 as a putative therapeutic target. in Molecular pharmacology 2005
Show all 3 Pubmed References
These results indicate that Phosphodiesterase-4D overexpression may be involved in the development of surgery-induced cognitive dysfunction in mice.
The effect of dobutamine as a positive inotrope is impaired in mice with cecal ligation and puncture-induced sepsis without changes in cardiac beta1-adrenoceptor signaling as a result of cAMP breakdown achieved by upregulated phosphodiesterase 4D
In vivo knockdown of (show FN1 Antibodies) PDE4D5 inhibited inflammation at athero-prone sites (show TWIST1 Antibodies)
Results indicate that the cyclic AMP (show TMPRSS5 Antibodies) (cAMP) increase is caused by the attenuation of phosphodiesterase (PDE (show TWIST1 Antibodies)) activity adrenal cortex-derived Y-1 cell line.
The authors demonstrate that the Attention Deficit Disorder with Hyperactivity phenotype depends on a dysregulation of CREB (show CREB1 Antibodies) signaling exerted by a kinase-independent PI3Kgamma (show PIK3CG Antibodies)-PDE4D interaction in the noradrenergic neurons of the locus coeruleus.
SIK1 (show SIK1 Antibodies) serves as a part of a self-regulatory circuit to modulate insulin (show INS Antibodies) secretion from pancreatic beta-cells by controlling cAMP concentration through modulation of PDE4D activity.
Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle, contributing to colonic dysmotility during inflammation.
the loss of function of either DISC1 (show DISC1 Antibodies) or ATF4 (show ATF4 Antibodies) increases PDE4D9 transcription, and the association of DISC1 (show DISC1 Antibodies) with the PDE4D9 locus requires ATF4 (show ATF4 Antibodies)
these results suggest that Pde4d might serve specific biological functions in regulating the development process of the mouse embryo, and that CpG methylation of the Pde4d promoter may play an important role in regulating Pde4d at a transcriptional level.
Calcineurin regulates degradation of phosphodiesterase 3B (show PDE3B Antibodies), in addition to phosphodiesterase 4D.
SNP 83 of PDE4D gene may increase the risk for developing ischemic stroke whereas SNP 87 and SNP45 of PDE4D may not be associated with the risk of ischemic stroke in the North Indian population
Results provide new information concerning the mechanism whereby the mutations identified in the ACRDYS2 dysregulate PDE4D activity, and give insights into rare diseases involving the cAMP signaling pathway.
This supports PDE4D5 and RACK1 as potential regulators of cell adhesion, spreading and migration through the non-classical exchange protein activated by cyclic AMP (EPAC1)/Rap1 signalling route
PDE4D isoform composition is altered in localized prostate cancer and it can be used both as a diagnostic as well as a prognostic biomarker.
Genetic analysis identified the identical, novel heterozygous missense mutation of the PDE4D gene c.569C>T (p.Ser190Phe) in two patients in same family. This case illustrates the significant phenotypic variability of acrodysostosis even within one family with identical mutations.
Screening of PRKAR1A (show PRKAR1A Antibodies) and PDE4D in a Large Italian Series of Patients Clinically Diagnosed With Albright Hereditary Osteodystrophy and/or Pseudohypoparathyroidism
p53 (show TP53 Antibodies) induced the transcription of miR (show MLXIP Antibodies)-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an oncogenic protein involved in multiple tumor promoting processes.
High PDE4D expression is associated with melanoma.
cells on fibronectin (show FN1 Antibodies) suppressed cAMP via enhanced phosphodiesterase (PDE (show ALDH7A1 Antibodies)) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5
we performed a meta-analysis of 15 studies, involving 8731 IS patients and 10,756 controls. The results showed nonsignificant association between PDE4D SNP56 and IS risk (T vs. A: OR=1.01, 95%CI=0.88-1.15, P=0.90). Similarly, in the subgroup analysis by ethnicity, no significant association was observed in Asian (T vs. A: OR=1.08, 95%CI=0.80-1.44, P=0.62) or European (T vs. A: OR=0.96, 95%CI=0.86-1.08, P=0.54) population.
demonstrate the presence of PDE4D transcript and protein, but also show an active enzyme, suggesting a functional role of PDE4D in bovine mammary gland
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
phosphodiesterase E3 dunce homolog, Drosophila
, phosphodiesterase 4D, cAMP-specific
, cAMP-specific 3',5'-cyclic phosphodiesterase 4D-like
, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
, cAMP-specific 3',5'-cyclic phosphodiesterase 4D
, cAMP-specific phosphodiesterase 4D
, cyclic AMP specific phosphodiesterase PDE4D5A
, cAMP-specific phosphodiesterase PDE4D6
, Phosphodiesterase 4D cAMP-specific (dunce
, Phosphodiesterase 4D, cAMP-specific (dunce
, cAMP-specific phosphodiesterase PDE4D
, cAMP-specific phosphodiesterase splice variant PDE4D8
, phosphodiesterase 4D, cAMP specific
, hypothetical protein