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Human High Mobility Group Nucleosome Binding Domain 1 (HMGN1) interaction partners

1. Studies indicate that high mobility group nucleosome binding domain 1 (HMGN1) preferentially promotes Th1-type immunity, which makes it relevant for the fields of vaccinology, autoimmunity, and oncoimmunology [Review].

2. HMGN1 and HMGN 2 remodel core and linker histone tail domains within chromatin.

3. RNA-seq evidence of biallelic expression of HMGN1 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of HMGN1 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals.

4. HMGN1 can serve as a useful clinical parameter for evaluating disease progression and predicting the outcomes for early-stage patients with non-small cell lung cancer .

5. nucleosome binding protein HMGN1 as a new PCNA-interacting protein that enhances the binding of PCNA to chromatin

6. extracellular HMGN1 acts as a novel alarmin critical for LPS-induced development of innate and adaptive immune responses.

7. HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) in mouse and human, and affects the behavior of mice

8. HMGN1 is not randomly distributed throughout the genome. Instead, the protein preferentially localizes to DNase I hypersensitive (HS) sites, promoters, functional enhancers, and transcription factor binding sites.

9. Results show that four serine residues, i.e., Ser6, Ser85, Ser88, and Ser98, can be phosphorylated in high mobility group N1 (HMGN1).

10. HMGN1 optimizes the cellular response to ionizing radiation and to other tumorigenic events; therefore, loss of this protein increases the tumor burden in mice.

11. SWI/SNF functions independently of HMGN1

12. Five serine residues, i.e., Ser6, Ser7, Ser85, Ser88, and Ser98, in HMGN1 can be phosphorylated by the kinase in vitro, and Ser6, Ser7, and Ser85 were new sites among these five sites.

13. These findings indicate that HMGN1 regulates the expression of particular genes via specific protein-protein interactions with transcription factors at target gene regulatory regions.

14. These studies demonstrate that the mode of binding of HMGNs to chromatin is cell cycle dependent.

15. HMGN1 (HMG14) and HMGN2 (HMG17) potently repress ATP-dependent chromatin remodeling by four different molecular motor proteins.

Mouse (Murine) High Mobility Group Nucleosome Binding Domain 1 (HMGN1) interaction partners

1. High mobility group nucleosomal binding proteins HMGN1 and HMGN2 proteins modulate the plasticity of the chromatin epigenetic landscape thereby stabilizing, rather than determining cell identity.

2. Suggest Hmgn1/Cebpb signaling may play an important role during mouse decidualization.

3. our findings show that HMGN1 contributes to antitumor immunity and it may offer an effective adjuvant to heighten responses to cancer vaccines.

4. in mice, loss of HMGN1 leads to transcription changes that accelerate the progression of DEN-induced hepatocarcinogenesis, without affecting the type of tumors or the final total tumor burden of these mice.

5. HMGN1 is a nucleosome remodeling protein encoded on chromosome 21q22 that suppresses H3K27me3 and promotes both B cell proliferation in vitro and B-ALL in vivo

6. HMGN1 binds to CpG island-containing promoters and affects the organization of nucleosomes, DNase I hypersensitivity, and the transcriptional profile of mouse embryonic stem cells and neural progenitors.

7. Phenotypic analysis of Hmgn1(tm1/tm1), Hmgn3(tm1/tm1), and Hmgn5(tm1/tm1) mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities.

8. a regulatory role for HMGN1 in PARP-1 activation.

9. extracellular HMGN1 acts as a novel alarmin critical for LPS-induced development of innate and adaptive immune responses.

10. HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) in mouse and human, and affects the behavior of mice

11. Regulation of Hmgn1 and Fgf18 at the digit-interdigit junction suggests retinoic acid controls tissue remodeling as well as apoptosis.

12. Data show that HMGN1, a nuclear protein that binds to nucleosomes and reduces the compaction of the chromatin fiber, modulates histone posttranslational modifications.

13. HMGN1, a nucleosomal binding protein that reduces the compaction of the chromatin fiber, increases the levels of acetylation of K14 in H3

14. Hmgn1 modulates the expression of cadherins.

15. HMGN1 plays role in chromatin remodeling during embryogenesis and in the activation of Sox9 during chondrogenesis.

16. HMGN1 levels naturally decrease as a function of contact-mediated cell cycle arrest.

17. HMGN1 enhances the rate of heat shock-induced H3K14 acetylation in the Hsp70 promoter

18. Thus, by regulating the levels of histone modifications, HMGN1 affects ATM activation.

19. Results show that the appearance of the skin and hair follicle of Hmgn1(-/-) mice was indistinguishable from that of their Hmgn1(+/+) littermates.