Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

HMGN1 antibody (High Mobility Group Nucleosome Binding Domain 1) (Middle Region) Primary Antibody

HMGN1 Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit WB Host: Rabbit Polyclonal unconjugated
Pubmed (1)
Catalog No. ABIN2780630
$389.00
Plus shipping costs $45.00
100 μL ABIN2780630
100 μL ABIN2780630
local_shipping Shipping to: United States
Delivery in 2 to 3 Business Days
  • Target
    HMGN1
    Binding Specificity
    • 17
    • 16
    • 15
    • 15
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 70
    • 15
    • 12
    • 8
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
    Host
    • 72
    Rabbit
    Clonality
    • 72
    Polyclonal
    Conjugate
    • 30
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This HMGN1 antibody is un-conjugated
    Application
    • 40
    • 31
    • 28
    • 26
    • 26
    • 16
    • 11
    • 6
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    QTKGKRGAKG KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD
    Predicted Reactivity
    Cow: 93%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 93%, Rat: 79%
    Characteristics
    This is a rabbit polyclonal antibody against HMGN1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human HMGN1
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 100 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Lane, Chapuy, Lin, Tivey, Li, Townsend, van Bodegom, Day, Wu, Liu, Yoda, Alexe, Schinzel, Sullivan, Malinge, Taylor, Stegmaier, Jaffe, Bustin, te Kronnie, Izraeli, Harris, Stevenson, Neuberg et al.: "Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. ..." in: Nature genetics, Vol. 46, Issue 6, pp. 618-23, 2014 (PubMed).

  • Target
    HMGN1
    Alternative Name
    HMGN1 (HMGN1 Antibody Abstract)
    Synonyms
    HMG14, hmg14, hmgn1, hmgn1b, HMG-14, Hmg14, high mobility group nucleosome binding domain 1, high mobility group nucleosome binding domain 1 S homeolog, high mobility group nucleosomal binding domain 1, non-histone chromosomal protein HMG-14, HMGN1, hmgn1.S, hmgn1, Hmgn1, LOC785479
    Background
    Chromosomal protein HMG14 (HMGN1) and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: FLJ27265, FLJ31471, HMG14, MGC104230, MGC117425
    Protein Interaction Partner: UBC, RPS6KA3, PRKCA, PRKACG, SLC38A3, PPP1CC, LIG4, PPIP5K1, TERF2, SPP1, POLR2A, ERCC8, HDGF, EP300, BTG2, ERCC6, NFE2, RPS6KA5, RPS6KA4, PRKACA, YWHAZ, HMGN1, HMGN2, IRF2,
    Protein Size: 100
    Molecular Weight
    11 kDa
    Gene ID
    3150
    NCBI Accession
    NM_004965, NP_004956
    UniProt
    Q6NSG7
    Pathways
    Chromatin Binding
You are here:
help Support