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Human Mannan-Binding Lectin serine Peptidase 2 (MASP2) interaction partners

1. High MAp19 concentration is associated with microalbuminuria in newly diagnosed type 1 diabetes.

2. The complement lectin pathway serine proteases, MASP-1 (show MASP1 Proteins) and MASP-2, can be associated with ischaemic stroke development risk and may participate in pathological events leading to post-ischaemic brain damage. Moreover rs3203210 and rs147270785 single nucleotide polymorphisms in the MASP1 (show MASP1 Proteins) and MASP2 genes, respectively, are strongly associated with ischaemic stroke.

3. The results of this study show that MASP-2 contributes to severity and outcome in pneumococcal meningitis. In patients with pneumococcal meningitis, MASP-2 concentration was elevated in the CSF (show CSF2 Proteins) and high levels were associated with poor functional outcome.

4. Genetically determined MASP-2 levels seem to have a two-edge effect in HIV and probably HCV/HBV coinfection, whereas low levels increase the susceptibility to infection, but on the other side protects against AIDS.

5. MASP-2 was not associated with adverse cardiovascular outcomes in diabetics.

6. This is the first comprehensive meta-analysis indicates that the MASP-2 functional gene (rs72550870) polymorphism is not associated with the infection diseases, and the key functional gene polymorphism of rs72550870 did not increase susceptibility to the infection diseases.

7. This study suggests that hMASP-2 can induce a protective efficacy in BCG (show SLC11A1 Proteins)-infected rabbit skin models, which affects both the progress of lesions and the survival of the mycobacteria within them.

8. The ficolin-3 (show FCN3 Proteins)/MASP-2 complex was significantly lower in the cardiac syndrome X patients compared to controls.

9. MASP-1 (show MASP1 Proteins) and MASP-2 are activated during blood clotting. This activation is triggered by activated platelets and by the generation of fibrin during thrombotic reactions in vitro and in vivo, and may represent a novel activation/amplification mechanism in thromboinflammation.

10. MBL2 (show MBL2 Proteins) and MASP2 deficiencies protect against the development of systemic inflammatory response after pediatric cardiac surgery.

Mouse (Murine) Mannan-Binding Lectin serine Peptidase 2 (MASP2) interaction partners

1. MASP-2 has an essential role in the mediation of cerebral ischemia-reperfusion injury.

2. this study shows that MASP-2 contributes to the development of collagen Ab-induced arthritis

3. We induced anti-myeloperoxidase vasculitis in mice and showed that neither MASP-2- nor properdin-deficient mice were protected, suggesting that alternative pathway activation does not require properdin or the lectin pathway.

4. Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4.

5. Gene targeting of mouse TDP-43 (show TARDBP Proteins) negatively affects Masp2 expression.

6. ALI in H5N1-infected mice was caused by excessive complement activation, as demonstrated by deposition of C3, C5b-9, and MBL-C in lung tissue, and by up-regulation of MBL-associated serine protease-2 and the complement receptors C3aR (show C3AR1 Proteins) and C5aR (show C5AR1 Proteins).

7. study corroborates the essential function of MASP-2 in the lectin pathway and highlights the importance of mannan-binding lectin-independent lectin pathway activation in the host defense against pneumococci

8. Targeting of mannan-binding lectin (show MBL2 Proteins)-associated serine protease-2 (show PRSS2 Proteins) confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.

9. Recombinant protein of masp2 was made and purified.

10. MASP-2 is essential for the activation of C4 and sMAP plays a regulatory role in the activation of the lectin pathway.