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(Dentin Matrix Acidic phosphoprotein 1 (DMP1))

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Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

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Featured DMP1 Categories

DMP1 ELISA Kits

Reliable ELISA kits for a wide range of species.

DMP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DMP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Application IHC, ELISA, WB
Validations
Cat. No. ABIN2252469
Quantity 100 μg
Datasheet Datasheet

Recommended DMP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966317
Quantity 96 tests
Datasheet Datasheet

Recommended DMP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Human Cells
Validations
Cat. No. ABIN1691401
Quantity 50 μg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1473752
Quantity 1 mg
Datasheet Datasheet
Reactivity Cow
Source Yeast
Validations
Cat. No. ABIN1613969
Quantity 1 mg
Datasheet Datasheet

Synonyms and alternative names related to DMP1

dentin matrix acidic phosphoprotein 1 (DMP1), dentin matrix acidic phosphoprotein 1 (Cyan7822_2429), dentin matrix acidic phosphoprotein 1 (dmp1), dentin matrix acidic phosphoprotein 1 (Dmp1), dentin matrix protein 1 (Dmp1), ARHP, ARHR, AV020965, DENTMAT, Dmp, DMP-1, PP

Protein level used designations for DMP1

  • dentin matrix acidic phosphoprotein 1
  • dentin matrix protein 1
  • AG1
  • DMP-1
  • serine rich acidic phosphoprotein
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