Browse our Minichromosome Maintenance Complex Component 2 Proteins (MCM2)

Full name:: Minichromosome Maintenance Complex Component 2 Proteins (MCM2)

On www.antibodies-online.com are 5 Minichromosome Maintenance Complex Component 2 (MCM2) Proteins from 4 different suppliers available. Additionally we are shipping Minichromosome Maintenance Complex Component 2 Antibodies (251) and Minichromosome Maintenance Complex Component 2 Kits (13) and many more products for this protein. A total of 280 Minichromosome Maintenance Complex Component 2 products are currently listed.

Synonyms:: AA959861, AW476101, BM28, cb737, CCNL1, cdc19, CDCL1, CG7538, chunp6905, D3S3194, dMCM2, Dmel\\CG7538, DmeMCM2, DmMcm2, l(3)rL074, McM2, MCM2-7, MCM2_DROME, MCM7, Mcmd2, MITOTIN, mKIAA0030, PCR3, XMcm2

list all proteins	Gene Name	GeneID	UniProt
	MCM2	4171	P49736
Rat MCM2	MCM2	312538
	MCM2	17216	P97310
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Top referenced Minichromosome Maintenance Complex Component 2 Proteins

Human MCM2 Protein expressed in Wheat germ - ABIN1310547 : Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011 (PubMed)

More Proteins for Minichromosome Maintenance Complex Component 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

Data show the structure of the Cdc45/Mcm2-7/Psf1 GINS (CMG) helicase in the presence of ATPgammaS and a DNA duplex bearing a 3' single-stranded tail.

Zebrafish Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

the foxn1 (show FOXN1 Proteins)-mcm2 axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish

Human Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

MCM2 played important roles in regulating cell cycle- and DNA replication-related pathways. E2F (show E2F1 Proteins) could upregulate the expression levels of MCM2 by deregulating the methylations of their promoters to promote the relapse of Acute Lymphoblastic Leukemia .
ProEx C is an immunohistochemical cocktail containing antibodies direct against topoisomerase IIalpha (TOP2A (show TOP2A Proteins)) and minichromosome maintenance 2 (MCM2) proteins. This brief review covers the effective utility of ProEx C as adjunct tool in assessing the urothelial lesions in urine cytology, also providing prognostic and therapeutic information to help in clinical decisions.
the decreased growth of osteosarcoma cells by MCM2 or MCM3 knockdown was reversed by DHX9 overexpression, indicating that MCM2 and MCM3 activity was DHX9-dependent.
Results show that MCM2 is significantly upregulated in urothelial carcinoma.
Sld5 a component of GINS complex interacts with SIK1 and recruits it to the sites of DNA replication at the onset of S phase.
MCM2 expression in serrated colonic polyps demonstrates aberrant cellular proliferation and changes in the colonic microenvironment may promote adenoma morphogenesis and predisposition to malignancy.
these findings suggest that lnc-FTX may act as a tumor suppressor in hepatocellular carcinoma (HCC (show FAM126A Proteins)) through physically binding miR (show MLXIP Proteins)-374a and MCM2. It may also be one of the reasons for HCC (show FAM126A Proteins) gender disparity and may potentially contribute to HCC (show FAM126A Proteins) treatment
Data suggest that interaction of Mcm10 (show MCM10 Proteins) with Mcm2-7 multimer requires Mcm10 (show MCM10 Proteins) domain that contains amino acids 530-655, which overlaps with domain required for stable retention of Mcm10 (show MCM10 Proteins) on chromatin; Mcm10 (show MCM10 Proteins) conserved domain (amino acids 200-482) is essential for DNA replication; both conserved domain and Mcm2-7-binding domain are required for full activity of Mcm10 (show MCM10 Proteins).
MCM2-MCM6 (show MCM6 Proteins) complex is required for CHK2 (show CHEK2 Proteins) chromatin loading and its phosphorylation to DNA damage response in squamous cell carcinoma cells.
BD ProExtrade mark C assay containing MCM2 and TOP2A (show TOP2A Proteins) antibodies showed strong specific nuclear staining that correlated with increased cervical dysplasia and lesion severity.

Xenopus laevis Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

Data show that MRE11- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG) helicase complex.
Mcm2-7 associate with Cdc45 (show CDC45 Proteins) and GINS to form a relatively stable CMG (show CASK Proteins) (Cdc45 (show CDC45 Proteins)-MCM-GINS) complex.
ATM (show ATM Proteins) and ATR phosphorylate the functionally critical replication protein Mcm2 during both DNA damage and replication checkpoint responses in Xenopus egg extracts
MCM2-7 is the replicative helicase, dispensable for chromatin loading and pre-replicative complex (pre-RC) assembly, but required for origin unwinding during DNA replication

Mouse (Murine) Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

MCM2 is dynamically expressed in both proliferative and differentiated stromal cells during mouse periimplantation uterus. expression of Mcm2 is induced by progesterone action in the mouse uterine stroma. siRNA-mediated silencing of MCM2 arrests the cell cycle at G1-S transition during stromal cell proliferation. downregulation of Mcm2 could also compromise stromal cell differentiation.
MCM2 deficiency reduces DNA replication initiation in gene-rich regions of the genome.
these data demonstrate that active MCM2-7 repression is a physiologically important mechanism for RS-induced cell cycle arrest and genome maintenance on an organismal level.
Hematopoietic cells originally express higher levels MCM 2 protein and undergo more frequent apoptosis following doxorubicin-induced DNA-damage in the presence of the FLV envelope protein gp70 (show EMB Proteins).
Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma.
Accumulation and dynamics of Mcm2 are described during oogenesis and the first embryonic cell cycle.
gp70 (show EMB Proteins) enhances cellular DNA-damage-induced signaling in association with host-specific cellular proteins including acinus (show ACIN1 Proteins) and MCM2 resulting in the activation of DNA-PK to phosphorylate P53 (show TP53 Proteins).

Minichromosome Maintenance Complex Component 2 (MCM2) Protein Profile

Protein Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.

Alternative names and synonyms associated with Minichromosome Maintenance Complex Component 2 (MCM2)

Minichromosome maintenance 2 (Mcm2)
minichromosome maintenance complex component 2 (mcm2)
minichromosome maintenance complex component 2 (MCM2)
minichromosome maintenance complex component 2 (Mcm2)
minichromosome maintenance complex component 2 L homeolog (mcm2.L)

AA959861 protein
AW476101 protein
BM28 protein
cb737 protein
CCNL1 protein
cdc19 protein
CDCL1 protein
CG7538 protein
chunp6905 protein
D3S3194 protein
dMCM2 protein
Dmel\\CG7538 protein
DmeMCM2 protein
DmMcm2 protein
l(3)rL074 protein
McM2 protein
MCM2-7 protein
MCM2_DROME protein
MCM7 protein
Mcmd2 protein
MITOTIN protein
mKIAA0030 protein
PCR3 protein
XMcm2 protein

Protein level used designations for MCM2

CG7538-PA , Mcm2-PA , minichromosome maintenance 2 , DNA replication licensing factor mcm2 , MCM2 minichromosome maintenance deficient 2, mitotin , minichromosome maintenance protein 2 , DNA replication licensing factor MCM2 , cell devision cycle-like 1 , cyclin-like 1 , minichromosome maintenance deficient 2 (mitotin) , minichromosome maintenance protein 2 homolog , nuclear protein BM28 , minichromosome maintenance deficient 2 mitotin , BM28-homolog , p112 , xMCM2 , minichromosome maintenance complex component 7 , mini chromosome maintenance deficient 2

GENE ID	SPECIES
40973	Drosophila melanogaster
448458	Xenopus (Silurana) tropicalis
192338	Danio rerio
4171	Homo sapiens
312538	Rattus norvegicus
380451	Xenopus laevis
416027	Gallus gallus
484622	Canis lupus familiaris
510120	Bos taurus
17216	Mus musculus

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