Browse our anti-XRCC5 (XRCC5) Antibodies

Full name:: anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) Antibodies (XRCC5)

On www.antibodies-online.com are 250 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) Antibodies from 30 different suppliers available. Additionally we are shipping XRCC5 Kits (20) and XRCC5 Proteins (4) and many more products for this protein. A total of 290 XRCC5 products are currently listed.

Synonyms:: AI314015, KARP-1, KARP1, KU80, Ku86, KUB2, Kup80, NFIV, XRCC5, xrcc5-a

list all antibodies	Gene Name	GeneID	UniProt
	XRCC5	22596	P27641
	XRCC5	363247
	XRCC5	7520	P13010
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Most Popular Reactivities for anti-XRCC5 (XRCC5) Antibodies

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anti-Mouse (Murine) XRCC5 Antibodies:

anti-Rat (Rattus) XRCC5 Antibodies:

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Relevant Pathways for anti-XRCC5 Antibodies

DNA Damage Repair

More product categories related to XRCC5 Antibody

Top referenced anti-XRCC5 Antibodies

Human Monoclonal XRCC5 Primary Antibody for IF, IHC (p) - ABIN563391 : Nomura, Sogawa, Noda, Seimiya, Matsushita, Miura, Tomonaga, Yoshitomi, Imazeki, Takizawa, Mogushi, Miyazaki, Yokosuka: Serum anti-Ku86 is a potential biomarker for early detection of hepatitis C virus-related hepatocellular carcinoma. in Biochemical and biophysical research communications 2012 (PubMed)
Show all 3 Pubmed References
Human Polyclonal XRCC5 Primary Antibody for ELISA, WB - ABIN2475249 : Archer, Labrecque, Tyler, Meyer, Evans, Villemure, Casey, Diksic, Hakim, Trop: Measurement of cerebral blood flow and volume with positron emission tomography during isoflurane administration in the hypocapnic baboon. in Anesthesiology 1990 (PubMed)
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Human Monoclonal XRCC5 Primary Antibody for IP, WB - ABIN2475250 : Tilly, Johnson: Effect of several growth factors on plasminogen activator activity in granulosa and theca cells of the domestic hen. in Poultry science 1990 (PubMed)
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Human Monoclonal XRCC5 Primary Antibody for ICC, FACS - ABIN969463 : Nolens, Pignon, Koopmansch, Elmoualij, Zorzi, De Pauw, Winkler: Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines. in Breast cancer research : BCR 2010 (PubMed)
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Human Monoclonal XRCC5 Primary Antibody for FACS, IF - ABIN967266 : Ohno, Kunimoto, Nishizuka, Osada, Imagawa: Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression. in Biochemical and biophysical research communications 2009 (PubMed)
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Hamster Polyclonal XRCC5 Primary Antibody for IP, WB - ABIN151949 : Lorenzini, Johnson, Oliver, Tresini, Smith, Hdeib, Sell, Cristofalo, Stamato: Significant correlation of species longevity with DNA double strand break recognition but not with telomere length. in Mechanisms of ageing and development 2009 (PubMed)
Human Polyclonal XRCC5 Primary Antibody for ELISA, WB - ABIN251320 : Mayeur, Kung, Martinez, Izumiya, Chen, Kung: Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells. in The Journal of biological chemistry 2005 (PubMed)
Polyclonal XRCC5 Primary Antibody for WB - ABIN540885 : Park, Ciccone, Freie, Kurimasa, Chen, Li, Clapp, Lee: A positive role for the Ku complex in DNA replication following strand break damage in mammals. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against XRCC5 Interaction Partners

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) interaction partners

RT-PCR and immunobloting data show that inhibitory effect of sodium butyrate takes place at the level of Rad51 (show RAD51 Antibodies) and XRCC5 gene transcription and the content of Rad51 (show RAD51 Antibodies) and Ku80 proteins.
Ku (ku70 (show XRCC6 Antibodies)/ku80 heterodimer)roles in nonhomologous end joining and base excision repair pathways of DNA repair are overviewed.
the downregulation of Ku80 and an impairment of repair activity in squamous cells, which are mediated by miR (show MLXIP Antibodies)-31.
Inactivation of Ku80 and DNA-PKCS (show PRKDC Antibodies) causes reduced lifespan and bodyweight.
A novel role for free Ku70 (show XRCC6 Antibodies) and free Ku80 in altering base excision repair.
Ku80 plays an important role in base excision repair.
Ku70/80 binds to DNA double strand breaks (DSB) in all cell cycle stages and is likely actively displaced from DSB ends to free the DNA ends for DNA end resection and thus homologous recombination to occur.
There was a dose-dependent and time-dependent increase in Ku80 mRNA levels in nude mice that were inoculated with A549 cells and exposed to varying doses of irradiation.
Ku70 (show XRCC6 Antibodies)/86 binds to the Apaf1 (show APAF1 Antibodies) promoter and represses its activity.
Mobility of a major portion of Ku80 is not affected by DNA double strans breaks (DSBs) in order to find other DSBs in hamster cells.

Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) interaction partners

ATM (show ATM Antibodies)-dependent phosphorylation of CtIP (show RBBP8 Antibodies) and the epistatic and coordinated actions of MRE11 (show MRE11A Antibodies) and CtIP (show RBBP8 Antibodies) nuclease (show DCLRE1C Antibodies) activities are required to limit the stable loading of Ku on single-ended DNA double-strand breaks.
these results suggest that polymorphisms of XRCC5 play an important role in astrocytoma prognosis in the Chinese Han population which could be used in the determination of astrocytoma prognosis in clinical researches
SAF-A (show HNRNPU Antibodies), in concert with Ku, temporally regulates base damage repair in irradiated cell genome.
High XRCC5 expresiion is associated with medullary thyroid carcinoma.
Ku80 can be cleaved by caspases-2 at D726 upon a transient etoposide treatment. Caspase-2 (show CASP2 Antibodies)-mediated Ku80 cleavage promotes Ku80/DNA-PKcs (show PRKDC Antibodies) interaction as the D726A mutation diminished Ku80 interaction with DNA-PKcs (show PRKDC Antibodies)
m-calpain translocated as the result of calcium influx was involved in DNA double-strand breaks repair, especially in the non-homologous end-joining pathway through proteolysis of nuclear Ku80. Cleaved Ku80 was still able to form a heterodimer with Ku70 and enhance DNA repair activity.
Ku80 CTR (show CALCR Antibodies) (C-terminal region) is required for interaction with DNA-PKcs (show PRKDC Antibodies) on short segments of blunt ended 25bp dsDNA or 25bp dsDNA with a 15-base poly dA ssDNA extension, but this requirement is less stringent on longer dsDNA molecules (35bp blunt ended dsDNA) or 25bp duplex DNA with either a 15-base poly dT or poly dC ssDNA extension. Moreover, DNA-PKcs (show PRKDC Antibodies)-Ku complex forms on 25 bp DNA with poly-pyrimidine ssDNA extension.
Ku80 could predict the probability of resistance to neoadjuvant chemotherapy in lung adenocarcinoma, and reduced cisplatin and pemetrexed-induced apoptosis in A549 cells
results demonstrated that XRCC5 promoted colon cancer growth by cooperating with p300 (show EP300 Antibodies) to regulate COX-2 (show COX2 Antibodies) expression, and suggested that the XRCC5/p300 (show EP300 Antibodies)/COX-2 (show COX2 Antibodies) signaling pathway was a potential target in the treatment of colon cancers
Ku antigen displays the AP lyase (show APEX1 Antibodies) activity on a certain type of double-stranded DNA.

Xenopus laevis X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) interaction partners

VCP/p97 (show vcp Antibodies) extracts sterically trapped Ku70 (show XRCC6 Antibodies)/80 rings from DNA in double-strand break repair.
Double strand break (DSB)-induced ubiquitylation of Ku80 provides a mechanism to efficiently eliminate Ku from DNA for pre- and postrepair processes.

XRCC5 Antigen Profile

Antigen Summary

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Alternative names and synonyms associated with XRCC5

X-ray repair cross complementing 5 (XRCC5) antibody
X-ray repair complementing defective repair in Chinese hamster cells 5 (Xrcc5) antibody
X-ray repair cross complementing 5 (Xrcc5) antibody
X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog (xrcc5.L) antibody

AI314015 antibody
KARP-1 antibody
KARP1 antibody
KU80 antibody
Ku86 antibody
KUB2 antibody
Kup80 antibody
NFIV antibody
XRCC5 antibody
xrcc5-a antibody

Protein level used designations for XRCC5

, , , , , , , , , , , , , , , , , , , , , , , , , , Ku autoantigen X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) X-ray repair protein X-ray repair cross-complementing protein 5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) ATP-dependent DNA helicase II ATP-dependent DNA helicase 2 subunit 2-like x-ray repair cross-complementing protein 5-like ATP-dependent DNA helicase 2 subunit 2 ATP-dependent DNA helicase II 80 kDa subunit CTC box-binding factor 85 kDa subunit CTC85 CTCBF DNA repair protein XRCC5 Ku p80 ku autoantigen protein p86 homolog nuclear factor IV Ku autoantigen, 80kD) X-ray repair cross complementation (double-strand-break rejoining X-ray repair cross complementation (double-strand-break rejoining; Ku autoantigen, 80kD) 86 kDa subunit of Ku antigen Ku autoantigen, 80kDa Ku86 autoantigen related protein 1 TLAA lupus Ku autoantigen protein p86 thyroid-lupus autoantigen X-ray repair complementing defective repair in Chinese hamster cells 5

GENE ID	SPECIES
449614	Pan troglodytes
478902	Canis lupus familiaris
574279	Macaca mulatta
100173343	Pongo abelii
100347656	Oryctolagus cuniculus
100409742	Callithrix jacchus
100484832	Ailuropoda melanoleuca
100514133	Sus scrofa
100603811	Nomascus leucogenys
22596	Mus musculus
363247	Rattus norvegicus
7520	Homo sapiens
394397	Xenopus laevis
424222	Gallus gallus
531945	Bos taurus

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Show all anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) Antibodies with Pubmed References