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anti-Mouse (Murine) XRCC5 Antibodies:
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Human Monoclonal XRCC5 Primary Antibody for IF, IHC (p) - ABIN563391
Nomura, Sogawa, Noda, Seimiya, Matsushita, Miura, Tomonaga, Yoshitomi, Imazeki, Takizawa, Mogushi, Miyazaki, Yokosuka: Serum anti-Ku86 is a potential biomarker for early detection of hepatitis C virus-related hepatocellular carcinoma. in Biochemical and biophysical research communications 2012
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Human Polyclonal XRCC5 Primary Antibody for ELISA, WB - ABIN2475249
Archer, Labrecque, Tyler, Meyer, Evans, Villemure, Casey, Diksic, Hakim, Trop: Measurement of cerebral blood flow and volume with positron emission tomography during isoflurane administration in the hypocapnic baboon. in Anesthesiology 1990
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Human Monoclonal XRCC5 Primary Antibody for IP, WB - ABIN2475250
Tilly, Johnson: Effect of several growth factors on plasminogen activator activity in granulosa and theca cells of the domestic hen. in Poultry science 1990
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Human Monoclonal XRCC5 Primary Antibody for ICC, FACS - ABIN969463
Nolens, Pignon, Koopmansch, Elmoualij, Zorzi, De Pauw, Winkler: Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines. in Breast cancer research : BCR 2010
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Human Monoclonal XRCC5 Primary Antibody for FACS, IF - ABIN967266
Ohno, Kunimoto, Nishizuka, Osada, Imagawa: Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression. in Biochemical and biophysical research communications 2009
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Human Polyclonal XRCC5 Primary Antibody for ELISA, WB - ABIN251320
Mayeur, Kung, Martinez, Izumiya, Chen, Kung: Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells. in The Journal of biological chemistry 2005
Polyclonal XRCC5 Primary Antibody for WB - ABIN540885
Park, Ciccone, Freie, Kurimasa, Chen, Li, Clapp, Lee: A positive role for the Ku complex in DNA replication following strand break damage in mammals. in The Journal of biological chemistry 2004
Human Polyclonal XRCC5 Primary Antibody for IHC, IHC (p) - ABIN4329381
Heemers, Regan, Schmidt, Anderson, Ballman, Tindall: Androgen modulation of coregulator expression in prostate cancer cells. in Molecular endocrinology (Baltimore, Md.) 2009
Hamster Polyclonal XRCC5 Primary Antibody for IP, WB - ABIN151949
Lorenzini, Johnson, Oliver, Tresini, Smith, Hdeib, Sell, Cristofalo, Stamato: Significant correlation of species longevity with DNA double strand break recognition but not with telomere length. in Mechanisms of ageing and development 2009
Ku (ku70 (show XRCC6 Antibodies)/ku80 heterodimer)roles in nonhomologous end joining and base excision repair pathways of DNA repair are overviewed.
the downregulation of Ku80 and an impairment of repair activity in squamous cells, which are mediated by miR (show MLXIP Antibodies)-31.
Inactivation of Ku80 and DNA-PKCS (show PRKDC Antibodies) causes reduced lifespan and bodyweight.
A novel role for free Ku70 (show XRCC6 Antibodies) and free Ku80 in altering base excision repair.
Ku80 plays an important role in base excision repair.
Ku70/80 binds to DNA double strand breaks (DSB) in all cell cycle stages and is likely actively displaced from DSB ends to free the DNA ends for DNA end resection and thus homologous recombination to occur.
There was a dose-dependent and time-dependent increase in Ku80 mRNA levels in nude mice that were inoculated with A549 cells and exposed to varying doses of irradiation.
Ku70 (show XRCC6 Antibodies)/86 binds to the Apaf1 (show APAF1 Antibodies) promoter and represses its activity.
Mobility of a major portion of Ku80 is not affected by DNA double strans breaks (DSBs) in order to find other DSBs in hamster cells.
It was concluded that Ku86 deficiency accelerates high NaCl induced cellular senescence in cultured cells, C. elegans, and knockout mouse kidney.
ATM (show ATM Antibodies)-dependent phosphorylation of CtIP (show RBBP8 Antibodies) and the epistatic and coordinated actions of MRE11 (show MRE11A Antibodies) and CtIP (show RBBP8 Antibodies) nuclease (show DCLRE1C Antibodies) activities are required to limit the stable loading of Ku on single-ended DNA double-strand breaks.
these results suggest that polymorphisms of XRCC5 play an important role in astrocytoma prognosis in the Chinese Han population which could be used in the determination of astrocytoma prognosis in clinical researches
SAF-A (show HNRNPU Antibodies), in concert with Ku, temporally regulates base damage repair in irradiated cell genome.
High XRCC5 expresiion is associated with medullary thyroid carcinoma.
Ku80 can be cleaved by caspases-2 at D726 upon a transient etoposide treatment. Caspase-2 (show CASP2 Antibodies)-mediated Ku80 cleavage promotes Ku80/DNA-PKcs (show PRKDC Antibodies) interaction as the D726A mutation diminished Ku80 interaction with DNA-PKcs (show PRKDC Antibodies)
m-calpain translocated as the result of calcium influx was involved in DNA double-strand breaks repair, especially in the non-homologous end-joining pathway through proteolysis of nuclear Ku80. Cleaved Ku80 was still able to form a heterodimer with Ku70 and enhance DNA repair activity.
Ku80 CTR (show CALCR Antibodies) (C-terminal region) is required for interaction with DNA-PKcs (show PRKDC Antibodies) on short segments of blunt ended 25bp dsDNA or 25bp dsDNA with a 15-base poly dA ssDNA extension, but this requirement is less stringent on longer dsDNA molecules (35bp blunt ended dsDNA) or 25bp duplex DNA with either a 15-base poly dT or poly dC ssDNA extension. Moreover, DNA-PKcs (show PRKDC Antibodies)-Ku complex forms on 25 bp DNA with poly-pyrimidine ssDNA extension.
Ku80 could predict the probability of resistance to neoadjuvant chemotherapy in lung adenocarcinoma, and reduced cisplatin and pemetrexed-induced apoptosis in A549 cells
results demonstrated that XRCC5 promoted colon cancer growth by cooperating with p300 (show EP300 Antibodies) to regulate COX-2 (show COX2 Antibodies) expression, and suggested that the XRCC5/p300 (show EP300 Antibodies)/COX-2 (show COX2 Antibodies) signaling pathway was a potential target in the treatment of colon cancers
Ku antigen displays the AP lyase (show APEX1 Antibodies) activity on a certain type of double-stranded DNA.
VCP/p97 (show vcp Antibodies) extracts sterically trapped Ku70 (show XRCC6 Antibodies)/80 rings from DNA in double-strand break repair.
Double strand break (DSB)-induced ubiquitylation of Ku80 provides a mechanism to efficiently eliminate Ku from DNA for pre- and postrepair processes.
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa)
, X-ray repair protein
, X-ray repair cross-complementing protein 5
, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
, ATP-dependent DNA helicase II
, ATP-dependent DNA helicase 2 subunit 2-like
, x-ray repair cross-complementing protein 5-like
, ATP-dependent DNA helicase 2 subunit 2
, ATP-dependent DNA helicase II 80 kDa subunit
, CTC box-binding factor 85 kDa subunit
, DNA repair protein XRCC5
, Ku p80
, ku autoantigen protein p86 homolog
, nuclear factor IV
, Ku autoantigen, 80kD)
, X-ray repair cross complementation (double-strand-break rejoining
, X-ray repair cross complementation (double-strand-break rejoining; Ku autoantigen, 80kD)
, 86 kDa subunit of Ku antigen
, Ku autoantigen, 80kDa
, Ku86 autoantigen related protein 1
, lupus Ku autoantigen protein p86
, thyroid-lupus autoantigen
, X-ray repair complementing defective repair in Chinese hamster cells 5