XRCC5 antibody (AA 424-450)

Catalog No. ABIN3029653

This Rabbit Polyclonal antibody specifically detects XRCC5 in WB, ELISA, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for XRCC5 antibody (AA 424-450) (ABIN3029653)

Target: XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XRCC5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-XRCC5 Antibody

Binding Specificity: AA 424-450

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 424-450 from the human protein was used as the immunogen for this XRCC5 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the XRCC5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the XRCC5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for XRCC5

Target: XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))

Alternative Name: XRCC5

Background: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

UniProt: P13010

Pathways: DNA Damage Repair