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EBP Products

(Emopamil Binding Protein (Sterol Isomerase) (EBP))
The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2\; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008].

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Featured EBP Categories

EBP Antibodies

High quality antibodies with extensive validation data.

EBP ELISA Kits

Reliable ELISA kits for a wide range of species.

EBP Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended EBP Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IF, IHC, WB
Validations
  • (4)
Cat. No. ABIN7142288
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application IHC, ELISA, WB
Validations
  • (2)
Cat. No. ABIN2158626
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (3)
Cat. No. ABIN1881278
Quantity 400 μL
Datasheet Datasheet

Recommended EBP ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1118973
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1118974
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1118975
Quantity 96 tests
Datasheet Datasheet

Recommended EBP Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (4)
Cat. No. ABIN3100004
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3120933
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2712409
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our EBP products

Ausavarat, Tanpaiboon, Tongkobpetch, Suphapeetiporn, Shotelersuk: "Two novel EBP mutations in Conradi-Hünermann-Happle syndrome." in: European journal of dermatology : EJD, Vol. 18, Issue 4, pp. 391-3, (2008) (PubMed).

Lu, Dollé, Imholz, van t Slot, Verschuren, Wijmenga, Feskens, Boer: "Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations." in: Journal of lipid research, Vol. 49, Issue 12, pp. 2582-9, (2008) (PubMed).

Steijlen, van Geel, Vreeburg, Marcus-Soekarman, Spaapen, Castelijns, Willemsen, van Steensel: "Novel EBP gene mutations in Conradi-Hünermann-Happle syndrome." in: The British journal of dermatology, Vol. 157, Issue 6, pp. 1225-9, (2007) (PubMed).

Synonyms and alternative names related to EBP

emopamil binding protein (sterol isomerase) (Ebp), emopamil binding protein (sterol isomerase) L homeolog (ebp.L), emopamil binding protein (sterol isomerase) (ebp), emopamil binding protein (sterol isomerase) (EBP), phenylalkylamine Ca2+ antagonist (emopamil) binding protein (Ebp), AI255399, cdpx2, CDPX2, cho2, CHO2, cpx, CPX, cpxd, CPXD, mSI, Pabp, Td, zgc:91895

Protein level used designations for EBP

  • 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
  • D8-D7 sterol isomerase
  • emopamil-binding protein
  • cholestenol Delta-isomerase
  • phenylalkylamine binding protein
  • delta(8)-Delta(7) sterol isomerase
  • emopamil binding protein (sterol isomerase)
  • 3-beta-hydroxysteroid-delta-8,delta-7-isomerase
  • Chondrodysplasia punctata-2, X-linked dominant (Happle syndrome)
  • emopamil-binding protein (sterol isomerase)
  • sterol 8-isomerase
  • phenylalkylamine Ca2+ antagonist (emopamil) binding protein
  • tattered
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