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anti-Human LAT2 Antibodies:
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Human Monoclonal LAT2 Primary Antibody for ICC, FACS - ABIN94439
Duque-Afonso, Yalcin, Berg, Abdelkarim, Heidenreich, Lübbert: The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO. in Oncogene 2011
Show all 6 Pubmed References
Human Monoclonal LAT2 Primary Antibody for FACS, ICC - ABIN94440
Yamasaki, Ishikawa, Sakuma, Kanagawa, Cheng, Malissen, Saito: LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival. in Molecular and cellular biology 2007
Show all 4 Pubmed References
Mouse (Murine) Polyclonal LAT2 Primary Antibody for ICC, WB - ABIN125755
Horejsí, Zhang, Schraven: Transmembrane adaptor proteins: organizers of immunoreceptor signalling. in Nature reviews. Immunology 2004
Show all 5 Pubmed References
Human Monoclonal LAT2 Primary Antibody for FACS, IF - ABIN120727
Brdicka, Imrich, Angelisová, Brdicková, Horváth, Spicka, Hilgert, Lusková, Dráber, Novák, Engels, Wienands, Simeoni, Osterreicher, Aguado, Malissen, Schraven, Horejsí: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. in The Journal of experimental medicine 2002
Show all 3 Pubmed References
Mouse (Murine) Polyclonal LAT2 Primary Antibody for WB - ABIN125754
Volná, Lebduska, Dráberová, Símová, Heneberg, Boubelík, Bugajev, Malissen, Wilson, Horejsí, Malissen, Dráber: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. in The Journal of experimental medicine 2004
Show all 3 Pubmed References
Human Polyclonal LAT2 Primary Antibody for IHC (p), WB - ABIN302075
Tkaczyk, Horejsi, Iwaki, Draber, Samelson, Satterthwaite, Nahm, Metcalfe, Gilfillan: NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation. in Blood 2004
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LAT1 (show LAT Antibodies) and LAT2 were overexpressed in both pheochromocytoma and medullary thyroid carcinoma by comparison with normal tissues.
The detergent-induced stabilization of the purified human 4F2hc (show SLC3A2 Antibodies)-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution
Results suggest that leukemia cell proliferation can be significantly suppressed by blocking amino acid transporter (show SLC43A2 Antibodies) LAT3 (show SLC43A1 Antibodies).
The AML1 (show RUNX1 Antibodies)/ETO (show RUNX1T1 Antibodies) target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.
Inhibition of LAT (show ORC3 Antibodies) transporters may provide a novel therapeutic target in metastatic castration-resistant prostate cancer, via suppression of mammalian target of rapamycin (show FRAP1 Antibodies) complex 1 activity and M-phase cell cycle genes.
LAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy.
NTAL acts as a tumor suppressor that enhances the proximal signaling of leukemic blasts. The key downstream molecule responsible for the biological effect of TCR signaling is ERK (show EPHB2 Antibodies).
Data show that signaling via the androgen receptor (show AR Antibodies) and ATF4 (show ATF4 Antibodies) pathways regulates expression of the amino acid transporters LAT1 (show LAT Antibodies) and LAT3 (show SLC43A1 Antibodies), thereby coordinating their increased expression in prostate cancer cells.
LAT2 protein (NTAL) participates in the activation of the c-Met-Grb2 (show GRB2 Antibodies)-ERK (show EPHB2 Antibodies)-cPLA2 (show PLA2G4A Antibodies) signalling cascade at early stages of H. pylori infection.
LAT3 may play a crucial role in the development and maintenance of podocyte structure and function by regulating protein synthesis and the actin cytoskeleton.
distinct molecular LAT2 (show SLC7A8 Antibodies)-features determine bidirectional amino acid transport but only an unidirectional thyroid hormone (show PTH Antibodies) import.
NTAL is a negative regulator of FcepsilonRI (show FCER1A Antibodies) activation events in murine bone marrow-derived mast cells, independently of possible compensatory developmental alterations.
Cerebral cortex hyperthyroidism of newborn mct8 (show MCT8 Antibodies)-deficient mice transiently suppressed by lat2 (show SLC7A8 Antibodies) inactivation.
Our data define a novel link between LAB and beta-catenin (show CTNNB1 Antibodies) nuclear accumulation in dendritic cells that facilitates IFN-gamma (show IFNG Antibodies) responses during anti-fungal immunity
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI (show FCER1A Antibodies), tetraspanin CD9 (show CD9 Antibodies), transmembrane adaptor proteins NTAL and LAT (show LAT Antibodies), and cytoskeleton-regulatory proteins of the ERM (show ETV5 Antibodies) family
Dihydrotestosterone treatment increased the expression of LAT2 (show SLC7A8 Antibodies).
The expression of Mct8 (show MCT8 Antibodies) and L-type amino acid transporters Lat2 (show SLC7A8 Antibodies) and Lat1 (show SLC7A5 Antibodies) are determined in brain neurons during development.
Circulating thyroid hormones, thyrotropin and thyroid hormone-responsive (show THRSP Antibodies) genes remained unchanged in Slc7a8 (show SLC7A8 Antibodies)(-/-) mice, possibly because of functional compensation by the thyroid hormone (show PTH Antibodies) transporter Mct8 (show MCT8 Antibodies), which is co-expressed in many cell types
a crucial role of NTAL in signaling, via RhoA (show RHOA Antibodies), to mast cell cytoskeleton.
While SLP-76 (show LCP2 Antibodies) and LAT1 (show SLC7A5 Antibodies) depend on each other for many of their functions, LAT2 (show SLC7A8 Antibodies)/SLP-76 (show LCP2 Antibodies) interactions and SLP-76 (show LCP2 Antibodies)-independent LAT1 (show SLC7A5 Antibodies) functions also mediate a positive signaling pathway downstream of FcepsilonRI (show FCER1A Antibodies) in mast cells.
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
Williams-Beuren syndrome chromosomal region 15 protein
, Williams-Beuren syndrome chromosomal region 5 protein
, linker for activation of B-cells
, linker for activation of T cells, transmembrane adaptor 2
, linker for activation of T-cells family member 2
, membrane-associated adapter molecule
, non-T-cell activation linker
, Williams-Beuren syndrome chromosome region 5 homolog
, non-T cell activation linker
, linker for activation of T cells family, member 2
, L-type amino acid transporter subunit
, L-type amino acid transporter 2
, large neutral amino acids transporter small subunit 2
, solute carrier family 7 member 8
, solute carrier family 8 (cationic amino acid transporter, y+ system), member 7
, Williams-Beuren syndrome chromosome region 5-like protein
, Williams-Beuren syndrome chromosome region 15 homolog
, williams-Beuren syndrome chromosomal region 15 protein homolog
, Y+L amino acid transporter 2
, amino acid permease
, cationic amino acid transporter, y+ system
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
, solute carrier family 7 member 6
, y(+)L-type amino acid transporter 2