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FCGR3A Proteins

(Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

36 results

FCGR3A Origin: Human Host: HEK-293 Cells Recombinant > 95 % by SEC-HPLC SDS, SEC-HPLC, SPR
Catalog No. ABIN7536872
$1,083.08
Plus shipping costs $50.00
250 μg (More quantities available)
Shipping to: United States
Delivery in 7 to 10 Business Days
 
FCGR3A Origin: Human Host: HEK-293 Cells Recombinant > 95 % by SEC-HPLC SDS, SEC-HPLC, SPR
Catalog No. ABIN7536871
$1,083.08
Plus shipping costs $50.00
1 mg (More quantities available)
Shipping to: United States
Delivery in 7 to 10 Business Days
 
FCGR3A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Pubmed 1 reference
Catalog No. ABIN1353901
$459.80
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 14 Business Days
 
FCGR3A Origin: Cynomolgus Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7321023
$345.12
Plus shipping costs $50.00
50 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 15 Business Days
 
FCGR3A Origin: Human Host: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. SDS, WB, Imm, ELISA, AcA Active
Catalog No. ABIN7678350
$600.74
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 12 to 15 Business Days
 
FCGR3A Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Catalog No. ABIN6961127
$614.22
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 12 to 15 Business Days
 
FCGR3A Origin: Human Host: HEK-293 Cells Recombinant > 97 % as determined by reducing SDS-PAGE. Active
Catalog No. ABIN7195697
$1,039.20
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 15 Business Days
 
FCGR3A Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE. Active
Catalog No. ABIN7195704
$1,039.20
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 15 Business Days
 
FCGR3A Origin: Rat Host: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
Catalog No. ABIN7195703
$1,039.20
Plus shipping costs $50.00
100 μg
Shipping to: United States
Delivery in 11 to 15 Business Days
 
FCGR3A Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Catalog No. ABIN7317018
$1,716.00
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 15 Business Days
 
FCGR3A Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Catalog No. ABIN2870739
$350.77
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 2 to 4 Business Days
 
FCGR3A Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Catalog No. ABIN2870544
$1,201.54
Plus shipping costs $50.00
200 μg (More quantities available)
Shipping to: United States
Delivery in 2 to 4 Business Days
 
FCGR3A Origin: Cynomolgus Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Catalog No. ABIN7597356
$176.12
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 12 to 15 Business Days
 
FCGR3A Origin: Human Host: HEK-293 Cells Recombinant > 95 % by SDS-PAGE. Active
Catalog No. ABIN7534705
$313.50
Plus shipping costs $50.00
50 μg (More quantities available)
Shipping to: United States
Delivery in 7 to 10 Business Days
 
FCGR3A Origin: Human Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN6573507
$397.27
Plus shipping costs $50.00
50 μg (More quantities available)
Shipping to: United States
Delivery in 4 to 5 Business Days
 
FCGR3A Origin: Human Host: Mammalian Cells Recombinant Greater than 95 % as determined by SDS-PAGE. WB, ELISA
Catalog No. ABIN7705334
$527.82
Plus shipping costs $50.00
50 μg (More quantities available)
Shipping to: United States
Delivery in 15 to 20 Business Days
 
FCGR3A Origin: Human Host: HEK-293 Cells Recombinant > 95 % by SDS-PAGE.
Catalog No. ABIN7535300
$445.50
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 7 to 10 Business Days
 
FCGR3A Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Catalog No. ABIN7504321
$445.92
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 3 to 6 Business Days
 
FCGR3A Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, Imm, PC
Catalog No. ABIN7393661
$625.61
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 17 Business Days
 
FCGR3A Origin: Human Recombinant BCA
Catalog No. ABIN1685422
$635.88
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 9 to 12 Business Days
 
  • Type Protein
    • Protein
  • Application
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • ELISA
    • Immunogen (Imm)
    • Activity Assay (AcA)
    • Positive Control (PC)
    • Affinity Measurement (AM)
    • Affinity Purification (AP)
    • Immunoassay (IA)
    • Screening Assay (ScA)
    • Size-exclusion chromatography-High Pressure Liquid Chromatography (SEC-HPLC)
    • Surface Plasmon Resonance (SPR)
    • Antibody Drug Assay (ADA)
    • Antibody Array (AA)
    • Biochemical Assay (BCA)
    • Mass Spectrometry (MS)
  • Reactivity
    • Human
    • Mouse
    • Cynomolgus
    • Rat
  • Cited in publications
  • Images available
  • Preservative free only
  • Carrier free only
  • Host
    • HEK-293 Cells
    • Escherichia coli (E. coli)
    • Bacteria
    • Human Cells
    • Mammalian Cells
    • Wheat germ
    • Baculovirus infected Insect Cells
    • Eukaryota
  • Binding Specificity
    • AA 17-208
    • AA 17-206
    • AA 18-208
    • AA 26-108
    • AA 1-208
    • AA 107-189
    • AA 17-254
    • AA 24-190
    • AA 32-215
    • AA 5-240
    • AA 5-241
    • F176V
    • Phe176Val
    • V176F
    • Val176Phe-Mutant
  • Conjugate
    • His tag
    • Un-conjugated
    • Fc Tag
    • His tag,GST tag
    • Biotin,His-Avi Tag
    • Fc Tag,His tag
    • GST tag
    • HSA,His tag
    • His tag,AVI tag
    • His tag,AVI tag,Biotin
    • His tag,SUMO Tag
    • His-Avi Tag
    • His-Avi Tag,Biotin
    • mFc Tag
  • Protein Type
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Biological Activity
    • Biologically Active
  • Supplier
    • antibodies-online
    • ACROBiosystems
    • ProteoGenix
    • Abbexa
    • Abeomics
    • Cohesion Biosciences

Latest Publications for our FCGR3A Proteins

de Taeye, Bentlage, Mebius, Meesters, Lissenberg-Thunnissen, Falck, Sénard, Salehi, Wuhrer, Schuurman, Labrijn, Rispens, Vidarsson: "FcγR Binding and ADCC Activity of Human IgG Allotypes." in: Frontiers in immunology, Vol. 11, pp. 740, (2020) (PubMed).

Aoyama, Hashii, Tsukimura, Osumi, Harazono, Tada, Kiyoshi, Matsuda, Ishii-Watabe: "Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies." in: mAbs, Vol. 11, Issue 5, pp. 826-836, (2020) (PubMed).

Simonov, Ivanov, Smolov, Abbasova, Piskunov, Poteryaev: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).

Zhao, Li, Wu, Li, Liu, Wang, Liu, Li, Wang: "Identification of anti-CD16a single domain antibodies and their application in bispecific antibodies." in: Cancer biology & therapy, pp. 1-9, (2019) (PubMed).

Huang, Li, Liu, Ye, Fan, Yuan, Wu, Chen, Jin, Shen, Feng, Zhang: "Structural and functional characterization of MBS301, an afucosylated bispecific anti-HER2 antibody." in: mAbs, Vol. 10, Issue 6, pp. 864-875, (2019) (PubMed).

Dakshinamurthy, Mukunda, Prasad Kodaganti, Shenoy, Natarajan, Maliwalave, Halan, Murugesan, Maity: "Charge variant analysis of proposed biosimilar to Trastuzumab." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 46, pp. 46-56, (2017) (PubMed).

Hayes, Frostell, Cosgrave, Struwe, Potter, Davey, Karlsson, Anneren, Rudd: "Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactions." in: Journal of proteome research, Vol. 13, Issue 12, pp. 5471-85, (2014) (PubMed).

Sakamoto, Ito, Hatanaka, Soni, Mori, Sugimura: "Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9986-93, (2009) (PubMed).

Aliases for FCGR3A Proteins

Fc fragment of IgG receptor IIIa (FCGR3A) Proteins
Fc fragment of IgG receptor IIIa (Fcgr3a) Proteins
CD16 Proteins
CD16A Proteins
FCG3 Proteins
FCGR3 Proteins
Fcgr4 Proteins
FCGRIII Proteins
FCR-10 Proteins
FCRIII Proteins
FCRIIIA Proteins
IGFR3 Proteins
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