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HLA-ABC Products

(HLA-ABC)

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HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008].

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Featured HLA-ABC Categories

HLA-ABC Antibodies

High quality antibodies with extensive validation data.

Recommended HLA-ABC Antibodies

Product
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Application
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Datasheet Datasheet
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Cat. No. ABIN118899
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Datasheet Datasheet
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Latest Publications for our HLA-ABC products

Giersch, Hermanussen, Volz, Volmari, Allweiss, Sureau, Casey, Huang, Fischer, Lütgehetmann, Dandri: "Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice." in: Frontiers in microbiology, Vol. 12, pp. 671466, (2021) (PubMed).

Supp, Hahn, Combs, McFarland, Schwentker, Boissy, Boyce, Powell, Lucky: "Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Formation in Bilayer Engineered Skin Substitutes." in: Cell transplantation, Vol. 28, Issue 9-10, pp. 1242-1256, (2020) (PubMed).

Hasselmann, Coburn, England, Figueroa Velez, Kiani Shabestari, Tu, McQuade, Kolahdouzan, Echeverria, Claes, Nakayama, Azevedo, Coufal, Han, Cummings, Davtyan, Glass, Healy, Gandhi, Spitale et al.: "Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. ..." in: Neuron, (2019) (PubMed).

Gadkari, Zhao, Teklemariam, Hantash: "Human embryonic stem cell derived-mesenchymal stem cells: an alternative mesenchymal stem cell source for regenerative medicine therapy." in: Regenerative medicine, Vol. 9, Issue 4, pp. 453-65, (2014) (PubMed).

Zhao, Teklemariam, Hantash: "Heterelogous expression of mutated HLA-G decreases immunogenicity of human embryonic stem cells and their epidermal derivatives." in: Stem cell research, Vol. 13, Issue 2, pp. 342-54, (2014) (PubMed).

Jones, Kosmoliaptsis, Apps, Lapaque, Smith, Kono, Chang, Boyle, Taylor, Trowsdale, Allen: "HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 5, pp. 2990-7, (2011) (PubMed).

Zuo, Quinn, Tamblyn, Thomas, Feederle, Delecluse, Hislop, Rowe et al.: "The Epstein-Barr virus-encoded BILF1 protein modulates immune recognition of endogenously processed antigen by targeting major histocompatibility complex class I molecules trafficking on both the ..." in: Journal of virology, Vol. 85, Issue 4, pp. 1604-14, (2011) (PubMed).

Spentzou, Bergin, Gill, Cheeseman, Ashraf, Kaltsidis, Cashin-Cox, Anjarwalla, Steel, Higgs, Pozniak, Piechocka-Trocha, Wong, Anzala, Karita, Dally, Gotch, Walker, Gilmour, Hayes: "Viral inhibition assay: a CD8 T cell neutralization assay for use in clinical trials of HIV-1 vaccine candidates." in: The Journal of infectious diseases, Vol. 201, Issue 5, pp. 720-9, (2010) (PubMed).

Hinrichs, Föll, Bade-Döding, Huyton, Blasczyk, Eiz-Vesper: "The nature of peptides presented by an HLA class I low expression allele." in: Haematologica, Vol. 95, Issue 8, pp. 1373-80, (2010) (PubMed).

Narita, Masuko, Kurasaki, Kitajima, Takenouchi, Saitoh, Watanabe, Furukawa, Toba, Fuse, Aizawa, Kawakami, Oka, Sugiyama, Takahashi: "WT1 peptide vaccination in combination with imatinib therapy for a patient with CML in the chronic phase." in: International journal of medical sciences, Vol. 7, Issue 2, pp. 72-81, (2010) (PubMed).

Synonyms and alternative names related to HLA-ABC

major histocompatibility complex, class I, A (HLA-A), HLAA

Protein level used designations for HLA-ABC

  • HLA class I histocompatibility antigen, A-1 alpha chain
  • MHC class I antigen HLA-A heavy chain
  • antigen presenting molecule
  • leukocyte antigen class I-A
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