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HLA-DMB Products

(Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Categories

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008].

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Featured HLA-DMB Categories

HLA-DMB Antibodies

High quality antibodies with extensive validation data.

HLA-DMB Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HLA-DMB Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, IP
Validations
  • (5)
Cat. No. ABIN516478
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7189497
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IP
Validations
  • (3)
Cat. No. ABIN516481
Quantity 100 μg
Datasheet Datasheet

Recommended HLA-DMB ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Sandwich ELISA
Validations
Cat. No. ABIN417816
Quantity 96 tests
Datasheet Datasheet

Recommended HLA-DMB Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1306745
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3078873
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3097145
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our HLA-DMB products

Callahan, Nagymanyoki, Bonome, Johnson, Litkouhi, Sullivan, Hirsch, Matulonis, Liu, Birrer, Berkowitz, Mok: "Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 23, pp. 7667-73, (2008) (PubMed).

Klee, Finlay, McDonald, Attewell, Hebrink, Dyer, Love, Vasmatzis, Li, Beechem, Klee: "Bioinformatics methods for prioritizing serum biomarker candidates." in: Clinical chemistry, Vol. 52, Issue 11, pp. 2162-4, (2007) (PubMed).

Synonyms and alternative names related to HLA-DMB

major histocompatibility complex, class II, DM beta (HLA-DMB), RT1 class II, locus DMb (RT1-DMb), major histocompatibility complex, class II, DM beta (PATR-DMB), D6S221E, MHC-DMB, RING7, RT1.DMb, RT1.Mb

Protein level used designations for HLA-DMB

  • HLA class II histocompatibility antigen, DM beta chain
  • MHC class II HLA-DMB
  • MHC class II antigen DMB
  • MHC class II antigen HLA-DM beta chain
  • class II histocompatibility antigen, M beta chain
  • really interesting new gene 7 protein
  • MHC class II-like beta chain
  • RT1 class II, DM beta
  • major histocompatibility complex, class II, DM beta
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