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HLA-B27 Products

(HLA Class I Histocompatibility Antigen, B-27 alpha Chain (HLA-B27))
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008].

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Featured HLA-B27 Categories

HLA-B27 Antibodies

High quality antibodies with extensive validation data.

HLA-B27 ELISA Kits

Reliable ELISA kits for a wide range of species.

Recommended HLA-B27 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application FACS
Validations
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Cat. No. ABIN7490111
Quantity 100 tests
Datasheet Datasheet
Reactivity Human
Application WB, IF (cc), IF (p), ICC, IHC (fro), IHC (p), ELISA
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Cat. No. ABIN1385327
Quantity 100 μL
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Reactivity Human
Application WB, IHC (fro), IHC (p), ELISA
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Cat. No. ABIN1399981
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Recommended HLA-B27 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
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Cat. No. ABIN6967447
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
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Cat. No. ABIN6973683
Quantity 96 tests
Datasheet Datasheet
Reactivity Guinea Pig
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN777065
Quantity 96 tests
Datasheet Datasheet

Latest Publications for our HLA-B27 products

Levering, Wind, Sintnicolaas, Hooijkaas, Gratama: "Flow cytometric HLA-B27 screening: cross-reactivity patterns of commercially available anti-HLA-B27 monoclonal antibodies with other HLA-B antigens." in: Cytometry. Part B, Clinical cytometry, Vol. 54, Issue 1, pp. 28-38, (2003) (PubMed).

Synonyms and alternative names related to HLA-B27

major histocompatibility complex, class I, B (HLA-B), AS, HLAB, SPDA1

Protein level used designations for HLA-B27

  • HLA class I histocompatibility antigen, B alpha chain
  • MHC Class I HLA heavy chain
  • MHC HLA-B cell surface glycoprotein
  • MHC HLA-B transmembrane glycoprotein
  • MHC class I antigen GN00104
  • MHC class I antigen HLA-B heavy chain
  • MHC class I antigen SHCHA
  • leukocyte antigen class I-B
  • lymphocyte antigen
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