HPV16 E7 Antibodies
(Human Papilloma Virus 16 E7 (HPV-16 E7))
E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
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Featured HPV16 E7 Categories
HPV16 E7 Antibodies
High quality antibodies with extensive validation data.
Recommended HPV16 E7 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human Papillomavirus 16 (HPV-16)
Application
WB, IF (p), ELISA, FACS, IF (cc), IHC (p), IHC (fro), ICC
Validations
- (2)
- (1)
Cat. No.
ABIN2173795
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human Papillomavirus 16 (HPV-16)
Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN933526
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human Papillomavirus 16 (HPV-16), Virus
Application
WB, IF (p), IHC (p)
Validations
Cat. No.
ABIN1713352
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our HPV16 E7 products
: "Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth." in: International journal of oncology, Vol. 50, Issue 6, pp. 2011-2023, (2017) (PubMed).: "HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells." in: Tumour biology, Vol. 39, Issue 7, pp. 1010428317717140, (2017) (PubMed).
: "E6 and E7 oncoproteins from human papillomavirus type 16 induce activation of human transforming growth factor beta1 promoter throughout Sp1 recognition sequence." in: Viral immunology, Vol. 19, Issue 3, pp. 468-80, (2006) (PubMed).
: "Professionalism and team care in the clinical setting." in: Clinical anatomy (New York, N.Y.), Vol. 19, Issue 5, pp. 468-72, (2006) (PubMed).
: "Analysis of E7/Rb associations." in: Methods in molecular medicine, Vol. 119, pp. 363-79, (2005) (PubMed).
Synonyms and alternative names related to HPV16 E7
transforming protein E7 (E7)Protein level used designations for HPV16 E7
- transforming protein
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