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Agitoxin-2

BR, InhA 168147-41-9
Catalog No. ABIN2566170
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Quick Overview for Agitoxin-2 (ABIN2566170)

Application

Blocking Reagent (BR), Inhibition Assay (InhA)
  • Purpose

    Agitoxin-2 is a potent blocker of Kv1.1 and Kv1.3 channels

    Sequence

    AA sequence: Gly-Val-Pro-Ile-Asn-Val-Ser-Cys8-Thr-Gly -Ser-Pro-Gln-Cys14-Ile-Lys-Pro-Cys18-Lys-Asp- Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys28-Met-Asn -Arg-Lys-Cys33-His-Cys35-Thr-Pro-Lys-OH Disulfide bonds: Cys8-Cys28, Cys14-Cys33, Cys18-Cys35

    Specificity

    Agitoxin-2 is a potent blocker of Kv1.1 and Kv1.3 channels

    Characteristics

    Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated Kv1.3 and Kv1.1 channels. Agitoxin-2 inhibits Kv1.3 with an IC50 value of around 200 pM and Kv1.1 with an IC50 value of around 140 pM. This peptide toxin was originally isolated from the venom of the Israeli scorpion L. quinquestriatus hebraeus.

    Formula

    C169H278N54O48S8

    Solubility

    water and saline buffer
  • Restrictions

    For Research Use only
  • Format

    Powder

    Storage

    -20 °C
  • Molecular Weight

    4090.89 Da

    CAS-No

    168147-41-9
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