Deacetylase Inhibitor
Quick Overview for Deacetylase Inhibitor (ABIN2866118)
Application
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Specificity
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Deacetylase Inhibitor can be used to inhibit histone deacetylase (HDAC) activity.
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Characteristics
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Deacetylase Inhibitor can be used to inhibit histone deacetylase (HDAC) activity. Histone acetylation is known to play an important role in the regulation of chromatin structure and gene expression. Inhibition of HDAC activity leads to hyperacetylation of histones that results in changes in expression of a subset of genes and induction of cell cycle arrest, differentiation and apoptosis. Because of these properties, deacetylase inhibitors have been targeted as potential treatments for cancer and other diseases.
The Deacetylase Inhibitor is provided as a ready-to-use 100X stock solution in sterile distilled water. Once diluted, it can be added directly to the media of cultured cells and can also be used in functional assays to study HDAC inhibition. Optimal dilution concentrations of Deacetylase Inhibitor will vary depending on the cell type and assay used and should be determined by the researcher.
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Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
GeldanamycinInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- BiotinInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Herbimycin AInh 70563-58-5 [(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
17-GMB-APA-GAInh [(3R,5S,6R,7S,10S,11S)-21-[3-[4-(2,5-dioxopyrrol-1-yl)butanoylamino]propylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
TEMPOInh 2564-83-2 2,2,6,6-Tetramethylpiperidine 1-oxyl, 2,2,6,6-Tetramethyl-1-piperidinyloxy, free radical, (2,2,6,6-Tetramethyl-1-piperidinyl)oxidanyl, 1,1,5,5-tetramethylpentamethylene nitroxide, 2,2,6,6-Tetramethylpiperidine-1-oxyl
Triacsin CInh 76896-80-5 (3E)-1-Oxo-3-[(2E,4E,7E)-2,4,7-undecatrien-1-ylidene]triazane
TPCKInh 402-71-1 N-(4-Chloro-3-oxo-1-phenyl-2-butanyl)-4-methylbenzenesulfonamide
StaurosporineInh 62996-74-1 (2S,3R,4R,6R)-3-Methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
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Comment
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's Deacetylase Inhibitor can be used to inhibit histone deacetylase (HDAC) activity. Histone acetylation is known to play an important role in the regulation of chromatin structure and gene expression. Inhibition of HDAC activity leads to hyperacetylation of histones that results in changes in expression of a subset of genes and induction of cell cycle arrest, differentiation and apoptosis. Because of these properties, deacetylase inhibitors have been targeted as potential treatments for cancer and other diseases.
The Deacetylase Inhibitor is provided as a ready-to-use 100X stock solution in sterile distilled water. Once diluted, it can be added directly to the media of cultured cells and can also be used in functional assays to study HDAC inhibition. Optimal dilution concentrations of Deacetylase Inhibitor will vary depending on the cell type and assay used and should be determined by the researcher.
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Restrictions
- For Research Use only
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Format
- Liquid
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Storage
- -20 °C
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Storage Comment
- Store at -20°C. We recommend making aliquots during the first use and storing at -20°C to avoid freeze/thaw cycles.
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