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Dimethyl fumarate

InhA, Func 624-49-7
Catalog No. ABIN3220563
  • Application
    Inhibition Assay (InhA), Functional Studies (Func)
    Purpose
    Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.
    Characteristics
    Source of Compound: synthetic, AZL-O-211089
    Target: NF-κB inhibitor
    Receptor: KEAP1-Nrf2
    Purification
    All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
    Purity
    99 %
    Formula
    C6H8O4
    Solubility
    Soluble in water
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Solid
    Storage
    -20 °C
    Storage Comment
    For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
    Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
    Several freeze/thaw cycles should not damage the activity of our small molecule products.
    However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
    Expiry Date
    24 months
  • Background
    Immunology/Inflammation
    Molecular Weight
    144.13 g/mol
    CAS-No
    624-49-7
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