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Dimethyl fumarate

InhA, Func 624-49-7

Dimethyl fumarate (Dimethyl fumarate)

1 image

Catalog No. ABIN3220563

Quick Overview for Dimethyl fumarate (ABIN3220563)

Application

Inhibition Assay (InhA), Functional Studies (Func)

Purpose

Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.

Characteristics

Source of Compound: synthetic, AZL-O-211089
Target: NF-κB inhibitor
Receptor: KEAP1-Nrf2

Purification

All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.

Purity

99 %

Formula

C6H8O4

Solubility

Soluble in water
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Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

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Inh 98-92-0 Pyridine-3-carboxylic acid amide

SAHA (Vorinostat)
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Phenylbutyrate Na
Inh 1716-12-7 4-Phenylbutyric acid, sodium salt

CI-994
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Tranylcypromine hemisulfate (±)
Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt

Tenovin-1
Inh 380315-80-0 N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide

Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Solid

Storage

-20 °C

Storage Comment

For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.

Expiry Date

24 months
Background

Immunology/Inflammation

Molecular Weight

144.13 g/mol

CAS-No

624-49-7

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