Phone:: +1 877 302 8632
Fax:: +1 888 205 9894 (Toll-free)
E-Mail:: orders@antibodies-online.com

For best experience we recommend to activate Javascript in your browser.

Swinholide A

CC

Catalog No. ABIN924961

Quick Overview for Swinholide A (ABIN924961)

Application

Cell Culture (CC)

Purpose

Swinholide A is a natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells.

Purity

> 98 % (HPLC)
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

5-Azacytidine
Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

SAHA (Vorinostat)
Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid

Phenylbutyrate Na
Inh 1716-12-7 4-Phenylbutyric acid, sodium salt

CI-994
Inh 112522-64-2 4-(Acetylamino)-N-(2-aminophenyl)benzamide

Tranylcypromine hemisulfate (±)
Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt

Tenovin-1
Inh 380315-80-0 N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide

Application Notes

Can be used in cell biology to distinguish between the effects induced by increasing intracellular concentrations of G-actin from those induced by a reduction in F-actin.

Comment

Formula: C78H132O20

Restrictions

For Research Use only
Format

Oil

Storage

-20 °C
Background

Swinholide A is a 44-carbon dimeric dilactone ring macrolide isolated from the marine sponge Theonella swinhoei. In vitro, it sequesters actin dimers with a binding stochiometry of 1:1, and it rapidly severs F-actin with high cooperativity. Swinholice A is potently cytotoxic by disruption of the actin cytoskeleton. It does not block progression of cells through the cell cycle, but does prevent cytokinesis. Cytotoxcity: Cell Type IC50 (µg/ml) KB Oral, epidermoid cell carcinoma 0.04 HT-1080 Fibrosarcoma 0.017 PC-3 Lung, adenocarcinoma 6.0 PC-9 Lung, adenocarcinoma 0.13 PC-10 Lung, squamous cell carcinoma 0.11 PC-13 Lung, large cell carcinoma 0.10 Daudi Burkitt lymphoma 0.036.

Molecular Weight

1388.9 Da

You are here: