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Transplantation experiments demonstrated that med14 and brg1 (show SMARCA4 Antibodies) are required directly in neural crest cells. Analysis of med14; brg1 (show SMARCA4 Antibodies) double mutant embryos suggested the existence of strong genetic interaction between members of Mediator and BAF (show BANF1 Antibodies) complexes.
Functional analysis implicates TNRC6A, NAT10 (show NAT10 Antibodies), MED14, and WDR5 (show WDR5 Antibodies) in RNA-mediated transcriptional activation.
This results from a dramatically enhanced ability of MED14-containing complexes to associate with Pol II (show 0 Antibodies).
VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF (show CSF2 Antibodies) and MED14
DRIP150 binds to ISGF3 (show STAT1 Antibodies) and regulates transcription
CRSP2 gene is expressed in the retina and its exact genomic location is on Xp11.4 between DXS1368 and DXS993
Coactivation of ERalpha (show ESR1 Antibodies) by DRIP150 in ZR-75 cells is NR box-independent and requires a novel sequence with putative alpha-helical structure.
MED14 and MED1 (show MED1 Antibodies) are used by glucocorticoid receptor (show NR3C1 Antibodies) in a gene-specific manner, providing a mechanism for promoter selectivity by glucocorticoid receptor (show NR3C1 Antibodies)
Coactivator that enhances estrogen receptor alpha (show ESR1 Antibodies)- and specificity protein (SP)-1 (show PSG1 Antibodies)-mediated transactivation in breast cancer cells.
MED14 constitutes a novel anchoring point between Mediator and the N-terminal domain of PPARgamma (show PPARG Antibodies) that is necessary for functional PPARgamma (show PPARG Antibodies)-mediated recruitment of Mediator and transactivation of PPARgamma (show PPARG Antibodies) subtype-specific target genes.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
, mediator complex subunit 14
, cofactor required for Sp1 transcriptional activation, subunit 2
, mediator of RNA polymerase II transcription subunit 14
, cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa
, mediator of RNA polymerase II transcription subunit 14-like
, CRSP complex subunit 2
, RGR1 homolog
, activator-recruited cofactor 150 kDa component
, cofactor required for Sp1 transcriptional activation, subunit 2 (150kD)
, human homolog of yeast RGR1
, thyroid hormone receptor-associated protein complex 170 kDa component
, thyroid hormone receptor-associated protein complex component TRAP170
, transcriptional co-activator CRSP150
, vitamin D receptor-interacting protein complex component DRIP150
, vitamin D3 receptor-interacting protein complex 150 kDa component
, cofactor required for Sp1 transcriptional activation subunit 2 (150 kDa)
, hypothetical protein