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Transplantation experiments demonstrated that med14 and brg1 are required directly in neural crest cells. Analysis of med14; brg1 double mutant embryos suggested the existence of strong genetic interaction between members of Mediator and BAF complexes.
Functional analysis implicates TNRC6A, NAT10, MED14, and WDR5 in RNA-mediated transcriptional activation.
This results from a dramatically enhanced ability of MED14-containing complexes to associate with Pol II.
VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF and MED14
DRIP150 binds to ISGF3 and regulates transcription
CRSP2 gene is expressed in the retina and its exact genomic location is on Xp11.4 between DXS1368 and DXS993
Coactivation of ERalpha by DRIP150 in ZR-75 cells is NR box-independent and requires a novel sequence with putative alpha-helical structure.
MED14 and MED1 are used by glucocorticoid receptor in a gene-specific manner, providing a mechanism for promoter selectivity by glucocorticoid receptor
Coactivator that enhances estrogen receptor alpha- and specificity protein (SP)-1-mediated transactivation in breast cancer cells.
MED14 constitutes a novel anchoring point between Mediator and the N-terminal domain of PPARgamma that is necessary for functional PPARgamma-mediated recruitment of Mediator and transactivation of PPARgamma subtype-specific target genes.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
, mediator complex subunit 14
, cofactor required for Sp1 transcriptional activation, subunit 2
, mediator of RNA polymerase II transcription subunit 14
, cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa
, mediator of RNA polymerase II transcription subunit 14-like
, CRSP complex subunit 2
, RGR1 homolog
, activator-recruited cofactor 150 kDa component
, cofactor required for Sp1 transcriptional activation, subunit 2 (150kD)
, human homolog of yeast RGR1
, thyroid hormone receptor-associated protein complex 170 kDa component
, thyroid hormone receptor-associated protein complex component TRAP170
, transcriptional co-activator CRSP150
, vitamin D receptor-interacting protein complex component DRIP150
, vitamin D3 receptor-interacting protein complex 150 kDa component
, cofactor required for Sp1 transcriptional activation subunit 2 (150 kDa)
, hypothetical protein