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Mouse (Murine) IL-13 Protein expressed in Escherichia coli (E. coli) - ABIN1305069
Doherty, Kastelein, Menon, Andrade, Coffman: Modulation of murine macrophage function by IL-13. in Journal of immunology (Baltimore, Md. : 1950) 1994
Show all 3 Pubmed References
SOCS1 (show SOCS1 Proteins) inhibits epithelial IL-13 signalling, supporting its key role in regulating Th2-driven eosinophilia in severe asthma
IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells
This meta-analysis suggests that the T allele of rs1800925 is associated with the increased risk of COPD (show ARCN1 Proteins) in both Asians and Caucasians, whereas rs20541 is associated with the risk of COPD (show ARCN1 Proteins) in Caucasians but not in Asians.
the IL13-1112 C/T (rs1800925) polymorphism does not predict responsiveness to neoadjuvant chemoradiotherapy or prognosis of Chinese Han patients with locally advanced rectal cancer .
Different genotype profiles of IL13 gene seem to influence the clinical pattern of disease expression mainly confined to the upper airways, as rhinitis, or including the lower airways, as asthma
secretion of IL-13 and amphiregulin (show AREG Proteins) suggests Intrahepatic Innate lymphoid cells may be recruited to promote resolution and repair and thereby they may contribute to ongoing fibrogenesis in liver disease.
Increased baseline mRNA levels of the Th2-related cytokine IL-13 and the regulatory cytokine IL-10 (show IL10 Proteins) predicted a positive food challenge outcome.
These findings demonstrate that NF-kappaB (show NFKB1 Proteins)-mediated transcriptional mechanisms are critically involved in the IL-1beta (show IL1B Proteins)-mediated IL-17C (show IL17C Proteins) induction, and that IL-13 negatively regulates this induction by suppressing NF-kappaB (show NFKB1 Proteins)-based transcriptional activation.
These results suggested that IL-13 +1923C/T polymorphism contributed to the development of asthma.
IL13 AA of rs20541 and STAT4 (show STAT4 Proteins) TT of rs925847 are potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 AA may inhibit the advancement of airway remodelling. The genetic variants of STAT4 (show STAT4 Proteins) TT did not respond to high-dose ICSs.
the presence of interleukin-13 (IL-13), which can convert inflammatory into Ym1 (show CHI3L3 Proteins)+ alternatively activated macrophages, at (acinar-to-ductal metaplasia [ADM (show ADM Proteins)]), which then gives rise to pancreatic intraepithelial neoplasia lesions, is reported.
Data indicate that interleukin-33 (IL-33 (show IL33 Proteins))-induced Interleukin-13 (IL-13) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR (show EGFR Proteins)) expression.
this study shows that environmental IL-13 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 (show IL4 Proteins) and IL-13 are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
this study shows that ST2 (show SULT2A1 Proteins) regulates early IL-13 production in fungus-induced allergic airway inflammation
These observations suggest that IL-4 (show IL4 Proteins) and IL-13 likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (show HAND1 Proteins) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
MIF (show MIF Proteins)-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 (show GATA3 Proteins) expression and IL-13 production in the mesenteric lymph nodes
findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 (show TLR4 Proteins) signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response.
Study found IL-13 to be critically involved in the development of chemical-induced asthma, as shown by using IL-13 KO mice, and more specifically in the effector phase as confirmed by anti- IL-13 antibody treatment.
these studies show that fibrosis, steatosis, cholestasis, and ductular reaction are simultaneously controlled but distinctly regulated by interleukin-13 signaling
T helper (Th) type 2 cell cytokine IL-13 modulates airway contraction by secreting matrix metalloproteinase-1 (show MMP1 Proteins) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
, T-cell activation protein P600