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Mouse (Murine) IL-3 Protein expressed in Escherichia coli (E. coli) - ABIN1305116
Urdal, Mochizuki, Conlon, March, Remerowski, Eisenman, Ramthun, Gillis: Lymphokine purification by reversed-phase high-performance liquid chromatography. in Journal of chromatography 1984
Show all 6 Pubmed References
Human IL-3 Protein expressed in Escherichia coli (E. coli) - ABIN1305115
Frendl: Interleukin 3: from colony-stimulating factor to pluripotent immunoregulatory cytokine. in International journal of immunopharmacology 1992
Show all 3 Pubmed References
Human IL-3 Protein expressed in Escherichia coli (E. coli) - ABIN413516
Kinzfogl, Hangoc, Broxmeyer: Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells. in Blood 2011
Human IL-3 Protein expressed in Escherichia coli (E. coli) - ABIN803865
Han, Kitamoto, Wang, Boisvert: Interleukin-10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Human IL-3 Protein expressed in Escherichia coli (E. coli) - ABIN1112336
Vicker: F-actin assembly in Dictyostelium cell locomotion and shape oscillations propagates as a self-organized reaction-diffusion wave. in FEBS letters 2001
Jak1 (show JAK1 Proteins)-deficient hematopoietic stem cells exhibit increased quiescence, an inability to enter the cell cycle in response to hematopoietic stress, and a marked reduction in cytokine sensing, including in response to type I interferons and IL-3.
findings indicate that STAT5 (show STAT5A Proteins) contributes to the remarkable IL-3-mediated inhibition of RANKL (show TNFSF11 Proteins)-induced osteoclastogenesis by activating Id genes and their associated pathways.
c-Kit(+) Adipose tissue-derived mesenchymal stem cells (ASCs)may promote breast cancer growth and angiogenesis by a synergistic effect of c-Kit and IL-3. Our findings suggest that c-Kit(+) subpopulations of ASCs should be eliminated in fat grafts for breast reconstruction of cancer patients following mastectomy.
These impaired macrophage functions in leukemic mice were significantly corrected by IL-3 and GM-CSF (show CSF2 Proteins) treatment indicating the therapeutic benefit of these two cytokines in leukemia.
IL-3 signaling does not contribute to Jak2 (show JAK2 Proteins) V617F myeloproliferative neoplasm pathogenesis.
Thus, IL-3 plays an important role in the pathogenesis of SLE and the progression of lupus nephritis.
Cytoplasmic granule containing HERMES (show CD44 Proteins), NonO (show NONO Proteins), PSF, and G3BP1 (show G3BP1 Proteins) is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.
Stem cell factor (SCF (show KITLG Proteins)), but not interleukin-3 (IL-3), is a major effector of HSC (show FUT1 Proteins) maturation during embryonic day E9-E10.
study reports IL3 potentiates inflammation in sepsis; in model of abdominal sepsis, findings show innate response activator B cells produce IL3, which induces myelopoiesis of monocytes and neutrophils and fuels cytokine storm; IL3 deficiency protects against sepsis
these findings reveal a role for CSF-1 (show CSF1 Proteins) in mediating the IL-3 hematopoietic pathway through monopoiesis, which regulates expansion of CD11c (show ITGAX Proteins)+ macrophages.
The present study demonstrates for the first time that IL-3 has an important role in enhancing the migration of human MSCs through regulation of the CXCR4 (show CXCR4 Proteins)/SDF-1alpha axis. These findings suggest a potential role of IL-3 in improving the efficacy of MSCs in regenerative cell therapy.
These results indicate that IL-3 regulates endothelial cells-extracellular vesicles release, cargo and IL-3 angiogenic paracrine action via STAT5 (show STAT5A Proteins).
T-GM-CSF (show CSF2 Proteins) and -IL-3 significantly, and reciprocally, blunted receptor binding and myeloid progenitor cell proliferation activity of both FL-GM-CSF (show CSF2 Proteins) and -IL-3 in vitro and in vivo
Results show that IL-3 induces several signaling pathways associated with increased cell survival under oxidative stress. This activity correlates with previous fi ndings indicating glucose uptake stimulation by IL-3, which together contribute to an emerging picture of a broader mechanism promoting cell survival.
The IL-3/ GM-CSF (show CSF2 Proteins) effected on the myofibroblastic differentiation of human adipose derive stromal cells (hASCs) as well as it did on human dermal fibroblasts (HDFs).
Genetically engineered mesenchymal stromal cells produce IL-3 and TPO (show THPO Proteins) to further improve human scaffold-based xenograft models
IL-3 hardly down-regulates the alpha-chain (show FCGRT Proteins) of its receptor without depleting the common beta-chain (show CSF2RB Proteins), which enables extraordinarily sustained signaling events, predominantly the activation of Stat5 (show STAT5A Proteins).
genetic polymorphisms in the immune genes IL-3 rs181781 and CTLA4 (show CTLA4 Proteins) rs4553808 may influence the TAC (show IL2RA Proteins) dose-adjusted concentrations
Our results indicated that the IL-3 and IL-13 (show IL13 Proteins) polymorphisms were not associated with rheumatoid arthritis (RA). stratification analyses suggested that the IL-13 (show IL13 Proteins) rs1800925 CT and CT/CC genotypes increased the risk of RA in patients with erythrocyte sedimentation rate (ESR (show ESR1 Proteins)) <25.00. these findings suggest that the IL-13 (show IL13 Proteins) rs1800925 C/T polymorphism may be associated with increased risk of RA in ESR (show ESR1 Proteins)
results suggest that IL-3 and IL-12p40 could be considered as molecular predictors for recurrent wheezing due to RSV infection
cytokine that functions as a multi-lineage haemopoietic growth regulator
, hematopoietic growth factor
, mast cell growth factor
, multipotential colony-stimulating factor
, P-cell stimulating factor
, mast-cell growth factor
, multilineage-colony-stimulating factor
, colony-stimulating factor, multiple
, Hematopoietic growth factor
, Mast cell growth factor
, Multipotential colony-stimulating factor