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anti-Human STAT1 Antibodies:
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Human Monoclonal STAT1 Primary Antibody for ICS - ABIN1177190
Tanaka, Saito, Kunisawa, Kurashima, Wake, Suzuki, Shultz, Kiyono, Ishikawa: Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice. in Journal of immunology (Baltimore, Md. : 1950) 2012
Show all 6 Pubmed References
Human Polyclonal STAT1 Primary Antibody for CyTOF, FACS - ABIN4900633
Noser, Mael, Sakuma, Ohmine, Marcato, Lee, Ikeda: The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: implication for the defective interferon response in cancer cells. in Molecular therapy : the journal of the American Society of Gene Therapy 2007
Show all 5 Pubmed References
Human Polyclonal STAT1 Primary Antibody for WB - ABIN1881847
Clarke, Clifford, Jindarat, Proud, Pang, Belvisi, Knox: TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein. in The Journal of biological chemistry 2010
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Human Polyclonal STAT1 Primary Antibody for IHC, WB - ABIN361958
Heim: The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus. in Journal of receptor and signal transduction research 1999
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Human Polyclonal STAT1 Primary Antibody for IF (p), IHC (p) - ABIN674889
Wang, Wang, Song, Chu, Qu: Deficiency of interferon-gamma or its receptor promotes colorectal cancer development. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2015
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Human Polyclonal STAT1 Primary Antibody for IHC - ABIN967087
Schindler, Fu, Improta, Aebersold, Darnell: Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. in Proceedings of the National Academy of Sciences of the United States of America 1992
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Human Monoclonal STAT1 Primary Antibody for ICS - ABIN1177187
Townsend, Scarabelli, Davidson, Knight, Latchman, Stephanou: STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis. in The Journal of biological chemistry 2004
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Human Monoclonal STAT1 Primary Antibody for ICS - ABIN1177188
Varinou, Ramsauer, Karaghiosoff, Kolbe, Pfeffer, Müller, Decker: Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity. in Immunity 2003
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Human Monoclonal STAT1 Primary Antibody for IHC (p), IP - ABIN269146
Kovarik, Boudny, Kocak, Lauerova, Fait, Vagundova: Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation. in International journal of molecular medicine 2003
Show all 2 Pubmed References
Human Polyclonal STAT1 Primary Antibody for ELISA, ICC - ABIN6255991
Liu, Wu, Zhu, Li, Liu: IRG1 increases MHC class I level in macrophages through STAT-TAP1 axis depending on NADPH oxidase mediated reactive oxygen species. in International immunopharmacology 2018
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These results demonstrated that the IFNGinduced immunosuppressive properties of B7H1 (show CD274 Antibodies) in human BM and WJMSCs were mediated by STAT1 signaling, and not by PI3K (show PIK3CA Antibodies)/RACalpha (show AKT1 Antibodies) serine/threonineprotein kinase signaling
STAT1 plays a pivotal role as a tumor suppressor in glioma.
the present study revealed a negative correlation between the expression of the STAT-1 gene and the glioma grade, as well as between STAT-1 and mutant p53 (show TP53 Antibodies) expression. The negative correlation between STAT-1 and the pathological level of glioma suggested that STAT-1 may be associated with the occurrence and development of glioma, and may be a diagnostic biomarker and therapeutic target for the malignancy of glioma.
PARP9 (show PARP9 Antibodies) and PARP14 (show PARP14 Antibodies) regulate macrophage activation in macrophage cell lines treated with either IFNgamma or IL-4 (show IL4 Antibodies); PARP14 (show PARP14 Antibodies) silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNgamma) cells, whereas it suppresses anti-inflammatory gene expression and STAT6 (show STAT6 Antibodies) phosphorylation in M(IL-4 (show IL4 Antibodies)) cells
PVT1 interacts with STAT1 to inhibit IFN-alpha signaling and tumor cells proliferation.
STAT1 is associated with giant cell tumor of bone recurrence, which might serve as biomarker for giant cell tumor of bone recurrence
High STAT1 expression is associated with head and neck squamous cell carcinoma.
The research described here specifies where in the JAK (show JAK3 Antibodies)/STAT signaling cascade the IFN response is inhibited and which protein domain of nsP2 (show RTN2 Antibodies) is responsible for IFN inhibition. The results illuminate new aspects of antiviral defense and CHIKV counterdefense strategies and will direct the search for novel antiviral compounds.
These results reveal that STAT1 pS727 regulates growth and differentiation in JAK (show JAK3 Antibodies)-STAT activated neoplasms and suggest that Mediator kinase inhibition represents a therapeutic strategy to regulate JAK (show JAK3 Antibodies)-STAT signaling
Transcription factor STAT1 regulates the expression of LINC00174
STAT1 binds to the IL-22 (show IL22 Antibodies) promoter and directly antagonizes STAT3 (show STAT3 Antibodies)-mediated IL-22 (show IL22 Antibodies) induction.
Downregulated SOCS1 (show SOCS1 Antibodies) expression activates the JAK1 (show JAK1 Antibodies)/STAT1 pathway and promotes polarization of macrophages into M1 type.
The Lipopolysaccharide and IFN-beta (show IFNB1 Antibodies)-mediated increase of STAT1 mRNA and protein levels was abrogated by chelation of Zn(2+) with the membrane permeable chelator N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) in RAW 264.7 macrophages.
The possibility that the Gas6 (show GAS6 Antibodies)-Mer (show ERH Antibodies)-PI3K/Akt (show AKT1 Antibodies)-STAT1-LXR (show NR1H3 Antibodies)-Arg2 (show ARG2 Antibodies) pathway plays an essential role for resolving inflammatory response in acute lung injury.
The results of this study strongly indicated that release of interferons by neuronal cells expressing polyglutamine-TBP (show TBP Antibodies) leads to induction of STAT1 and consequent downregulation of miR (show MLXIP Antibodies)-29a/b by a series of cell signaling events.
STAT1 is required to protect B cell development during murine norovirus infection.
Rigidity plays a key role in the toxicity of multi-walled carbon nanotubes and results in increased inflammatory, immunologic, and fibrogenic effects in the lung. STAT1 is an important protective factor in the fibroproliferative response to rMWCNTs, regulating both induced TGF-beta1 (show TGFB1 Antibodies) production and Smad2 (show SMAD2 Antibodies)/3 phosphorylation status.
these results confirmed that myricitrin exhibited anti-inflammatory activity by blocking the activation of JAKs and the downstream transcription factor STAT1, which may result from the downregulation of NOX2 (show CYBB Antibodies)-dependent ROS (show ROS1 Antibodies) production mediated by myricitrin.
Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon response by inducing STAT1 degradation.
this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets
Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Antibodies)-STAT1) signaling pathway.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (show STAT2 Antibodies) nuclear translocation.
Nsp1beta inhibits interferon-activated (show MNDA Antibodies) STAT1/STAT2 (show STAT2 Antibodies) signal transduction by inducing karyopherin-alpha1 degradation.
STAT1 is involved in mediating the action of ghrelin (show GHRL Antibodies) on ovarian cell functions.
the majority of the STAT1/STAT2 (show STAT2 Antibodies)/IRF9 (show IRF9 Antibodies) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.
Nitric oxide-dependent increase in caspase-8 (show CASP8 Antibodies) mRNA levels is associated with phosphorylation of STAT-1 at Ser (show SIGLEC1 Antibodies)-727 and STAT1 binding to the caspase-8 (show CASP8 Antibodies) promoter in cultured lung endothelial cells.
Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.
Report interferon-tau dependent STAT1 regulation of SOCS (show CISH Antibodies) genes in bovine endometrium during estrus cycle and embryo implantation.
the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate
results show for the first time that interleukin-6 (show IL6 Antibodies) (IL), in the presence of its soluble receptor (show IFNAR1 Antibodies) (sIL (show STIL Antibodies)-6R), induces activation of JAK1 (show JAK1 Antibodies), JAK2 (show JAK2 Antibodies), and STAT1/STAT3 (show STAT3 Antibodies) proteins in bovine articular chondrocytes
Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (show CSN2 Antibodies) synthesis and fat metabolism.
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (show STAT2 Antibodies).
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 1-alpha/beta
, signal transducer and activator of transcription-1
, transcription factor ISGF-3 components p91/p84
, signal transducer and activator of transcription 1
, signal transducer and activator of transcription 4
, transcription factor ISGF-3
, activator of transcription
, signal transduction
, LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta
, signal transducer and activator of transcription 1, 91kDa
, signal transduction and activation of transcription 1
, signal transduction and activation of transcription 1a