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Human Monoclonal STAT1 Primary Antibody for ICS - ABIN1177190
Tanaka, Saito, Kunisawa, Kurashima, Wake, Suzuki, Shultz, Kiyono, Ishikawa: Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice. in Journal of immunology (Baltimore, Md. : 1950) 2012
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Human Polyclonal STAT1 Primary Antibody for CyTOF, FACS - ABIN4900633
Noser, Mael, Sakuma, Ohmine, Marcato, Lee, Ikeda: The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: implication for the defective interferon response in cancer cells. in Molecular therapy : the journal of the American Society of Gene Therapy 2007
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Human Polyclonal STAT1 Primary Antibody for WB - ABIN1881847
Clarke, Clifford, Jindarat, Proud, Pang, Belvisi, Knox: TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein. in The Journal of biological chemistry 2010
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Human Polyclonal STAT1 Primary Antibody for IF (p), IHC (p) - ABIN674889
Wang, Wang, Song, Chu, Qu: Deficiency of interferon-gamma or its receptor promotes colorectal cancer development. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2015
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Human Polyclonal STAT1 Primary Antibody for IHC, WB - ABIN361958
Heim: The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus. in Journal of receptor and signal transduction research 1999
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Human Polyclonal STAT1 Primary Antibody for IHC - ABIN967087
Schindler, Fu, Improta, Aebersold, Darnell: Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. in Proceedings of the National Academy of Sciences of the United States of America 1992
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Human Monoclonal STAT1 Primary Antibody for ICS - ABIN1177187
Townsend, Scarabelli, Davidson, Knight, Latchman, Stephanou: STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis. in The Journal of biological chemistry 2004
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Human Monoclonal STAT1 Primary Antibody for ICS - ABIN1177188
Varinou, Ramsauer, Karaghiosoff, Kolbe, Pfeffer, Müller, Decker: Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity. in Immunity 2003
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Human Monoclonal STAT1 Primary Antibody for IHC (p), IP - ABIN94471
Kovarik, Boudny, Kocak, Lauerova, Fait, Vagundova: Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation. in International journal of molecular medicine 2003
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Human Monoclonal STAT1 Primary Antibody for IP, WB - ABIN94473
Kovarik, Stoiber, Eyers, Menghini, Neininger, Gaestel, Cohen, Decker: Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway. in Proceedings of the National Academy of Sciences of the United States of America 2000
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Transcription factor STAT1 regulates the expression of LINC00174
Dysregulation of the IFN-gamma (show IFNG Antibodies)-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia
STAT1b plays a key role in enhancing the tumor suppressor function of STAT1a, in ESCC, in a manner that can be amplified by IFN-gamma (show IFNG Antibodies)
HSP90 (show HSP90 Antibodies) is an upstream regulator of the ACK1 (show TNK2 Antibodies)-dependent phosphorylation of STAT1 and STAT3 (show STAT3 Antibodies).
These findings suggest that IFN-a (show IFNA6 Antibodies) can inhibit HCV replication through a STAT2 (show STAT2 Antibodies)-dependent but STAT1-independent pathway, whereas IFN-g (show IFNG Antibodies) induces ISG expression and inhibits HCV replication exclusively through a STAT1- and STAT2 (show STAT2 Antibodies)-dependent pathway.
MxA (show MX1 Antibodies) inhibits hepatitis C virus replication through JAK (show JAK3 Antibodies)-STAT pathway activation.
These results indicate the potential involvement of STAT1 in the regulation of trophoblast behavior. Furthermore, STAT 1 functions are more efficiently inhibited by blocking its expression than its phosphorylation.
Authors detected the ERK (show EPHB2 Antibodies), p-ERK (show EPHB2 Antibodies) and STAT1 expression in 131 ESCC cases and 22 case-matched normal esophageal tissues adjacent to the tumors specimens. These findings provide pathological evidence that ERK (show EPHB2 Antibodies)/p-ERK (show EPHB2 Antibodies) is negatively correlated with STAT1 in ESCC.
129:Stat1 (-/-) is a unique model for studying the critical origins and risk reduction strategies in age-related ER(+) breast cancer. In addition, it can be used in preclinical trials of hormonal and targeted therapies as well as immunotherapies.
STAT1 knockdown using an inhibitor and siRNA attenuated the IL-17 (show IL17A Antibodies)-mediated increases in IL-6 (show IL6 Antibodies), IL-8 (show IL8 Antibodies) and VEGF (show VEGFA Antibodies) expression in A549 and H292 cells.
Downregulated SOCS1 (show SOCS1 Antibodies) expression activates the JAK1 (show JAK1 Antibodies)/STAT1 pathway and promotes polarization of macrophages into M1 type.
The Lipopolysaccharide and IFN-beta (show IFNB1 Antibodies)-mediated increase of STAT1 mRNA and protein levels was abrogated by chelation of Zn(2+) with the membrane permeable chelator N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) in RAW 264.7 macrophages.
The possibility that the Gas6 (show GAS6 Antibodies)-Mer (show ERH Antibodies)-PI3K/Akt (show AKT1 Antibodies)-STAT1-LXR (show NR1H3 Antibodies)-Arg2 (show ARG2 Antibodies) pathway plays an essential role for resolving inflammatory response in acute lung injury.
The results of this study strongly indicated that release of interferons by neuronal cells expressing polyglutamine-TBP (show TBP Antibodies) leads to induction of STAT1 and consequent downregulation of miR (show MLXIP Antibodies)-29a/b by a series of cell signaling events.
STAT1 is required to protect B cell development during murine norovirus infection.
Rigidity plays a key role in the toxicity of multi-walled carbon nanotubes and results in increased inflammatory, immunologic, and fibrogenic effects in the lung. STAT1 is an important protective factor in the fibroproliferative response to rMWCNTs, regulating both induced TGF-beta1 (show TGFB1 Antibodies) production and Smad2 (show SMAD2 Antibodies)/3 phosphorylation status.
these results confirmed that myricitrin exhibited anti-inflammatory activity by blocking the activation of JAKs and the downstream transcription factor STAT1, which may result from the downregulation of NOX2 (show CYBB Antibodies)-dependent ROS (show ROS1 Antibodies) production mediated by myricitrin.
Data suggest that histone acetylation drives elevated Stat1/Myd88 (show MYD88 Antibodies) expression in macrophages from mice with type 1 diabetes; this mechanism is exhibited in both peritoneal macrophages and bone marrow-differentiated macrophages. (Stat1 = signal transducer and activator of transcription 1; Myd88 (show MYD88 Antibodies) = myeloid differentiation primary response gene 88 (show MYD88 Antibodies))
the role of unphosphorylated STAT1 differs from that of P-STAT1, and represses apoptosis in macrophages to promote immune evasion during Mycobacterium tuberculosis infection.
Data show that RNF2 (show RNF2 Antibodies) promotes STAT1/STAT2 (show STAT2 Antibodies) disassociation from DNA.
Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (show IFNA Antibodies) response by inducing STAT1 degradation.
this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets
Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Antibodies)-STAT1) signaling pathway.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (show STAT2 Antibodies) nuclear translocation.
Nsp1beta inhibits interferon-activated (show MNDA Antibodies) STAT1/STAT2 (show STAT2 Antibodies) signal transduction by inducing karyopherin-alpha1 degradation.
STAT1 is involved in mediating the action of ghrelin (show GHRL Antibodies) on ovarian cell functions.
the majority of the STAT1/STAT2 (show STAT2 Antibodies)/IRF9 (show IRF9 Antibodies) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.
Nitric oxide-dependent increase in caspase-8 (show CASP8 Antibodies) mRNA levels is associated with phosphorylation of STAT-1 at Ser (show SIGLEC1 Antibodies)-727 and STAT1 binding to the caspase-8 (show CASP8 Antibodies) promoter in cultured lung endothelial cells.
Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.
Report interferon-tau dependent STAT1 regulation of SOCS (show CISH Antibodies) genes in bovine endometrium during estrus cycle and embryo implantation.
the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate
results show for the first time that interleukin-6 (show IL6 Antibodies) (IL), in the presence of its soluble receptor (show IFNAR1 Antibodies) (sIL (show STIL Antibodies)-6R), induces activation of JAK1 (show JAK1 Antibodies), JAK2 (show JAK2 Antibodies), and STAT1/STAT3 (show STAT3 Antibodies) proteins in bovine articular chondrocytes
Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (show CSN2 Antibodies) synthesis and fat metabolism.
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (show STAT2 Antibodies).
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 1-alpha/beta
, signal transducer and activator of transcription-1
, transcription factor ISGF-3 components p91/p84
, signal transducer and activator of transcription 1
, signal transducer and activator of transcription 4
, transcription factor ISGF-3
, activator of transcription
, signal transduction
, LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta
, signal transducer and activator of transcription 1, 91kDa