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KCC2 Products

(Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5))

Categories

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008].

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Featured KCC2 Categories

KCC2 Antibodies

High quality antibodies with extensive validation data.

KCC2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KCC2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Application WB, IHC, IP, IF, ICC
Validations
  • (4)
Cat. No. ABIN1027708
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (3)
Cat. No. ABIN652057
Quantity 400 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application IHC, IF
Validations
  • (3)
Cat. No. ABIN7075650
Quantity 100 μL
Datasheet Datasheet

Recommended KCC2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6210805
Quantity 96 tests
Datasheet Datasheet

Recommended KCC2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3118086
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3136773
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our KCC2 products

Dumon, Diabira, Chudotvorova, Bader, Sahin, Zhang, Porcher, Wayman, Medina, Gaiarsa: "The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice." in: eLife, Vol. 7, (2019) (PubMed).

Kwon, Neupane, Shin, Gwon, Yin, Shin, Shin, Hong, Park, Yi, Kim, Kang: "Calpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats." in: Experimental neurobiology, Vol. 28, Issue 4, pp. 529-536, (2019) (PubMed).

Huang, Grau: "Ionic plasticity and pain: The loss of descending serotonergic fibers after spinal cord injury transforms how GABA affects pain." in: Experimental neurology, Vol. 306, pp. 105-116, (2019) (PubMed).

Mahadevan, Khademullah, Dargaei, Chevrier, Uvarov, Kwan, Bagshaw, Pawson, Emili, De Koninck, Anggono, Airaksinen, Woodin: "Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition." in: eLife, Vol. 6, (2018) (PubMed).

Stödberg, McTague, Ruiz, Hirata, Zhen, Long, Farabella, Meyer, Kawahara, Vassallo, Stivaros, Bjursell, Stranneheim, Tigerschiöld, Persson, Bangash, Das, Hughes, Lesko, Lundeberg, Scott, Poduri et al.: "Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures. ..." in: Nature communications, Vol. 6, pp. 8038, (2015) (PubMed).

Mahadevan, Dargaei, Ivakine, Hartmann, Ng, Chevrier, Ormond, Nothwang, McInnes, Woodin: "Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures." in: Frontiers in cellular neuroscience, Vol. 9, pp. 368, (2015) (PubMed).

Toda, Ishida, Kiyama, Yamashita, Lee: "Down-regulation of KCC2 expression and phosphorylation in motoneurons, and increases the number of in primary afferent projections to motoneurons in mice with post-stroke spasticity." in: PLoS ONE, Vol. 9, Issue 12, pp. e114328, (2015) (PubMed).

He, Nomura, Xu, Contractor: "The developmental switch in GABA polarity is delayed in fragile X mice." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 2, pp. 446-50, (2014) (PubMed).

Markkanen, Karhunen, Llano, Ludwig, Rivera, Uvarov, Airaksinen: "Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS." in: The Journal of comparative neurology, Vol. 522, Issue 8, pp. 1897-914, (2014) (PubMed).

Law, Paquet, Kania: "Emergence of motor circuit activity." in: PLoS ONE, Vol. 9, Issue 4, pp. e93836, (2014) (PubMed).

Synonyms and alternative names related to KCC2

solute carrier family 12 member 5 (SLC12A5), solute carrier family 12 member 5 (Slc12a5), solute carrier family 12, member 5 (Slc12a5), Kcc2, KCC2, mKIAA1176

Protein level used designations for KCC2

  • solute carrier family 12 (potassium/chloride transporter), member 5
  • K-Cl cotransporter 2
  • electroneutral potassium-chloride cotransporter 2
  • furosemide-sensitive K-Cl cotransporter
  • neuronal K-Cl cotransporter
  • neuronal-specific K-Cl cotransporter
  • rKCC2
  • solute carrier family 12 member 5
  • solute carrier family 12, member 5
  • erythroid K-Cl cotransporter 2
  • hKCC2
  • mKCC2
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