SNCA ELISA Kit

Catalog No. ABIN1059104

Product Details SNCA ELISA Kit

Target: SNCA (Synuclein, alpha (SNCA))

Reactivity: Human

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Analytical Method: Quantitative

Characteristics: This ELISA assay kit provides a standard peptide solution with known concentration to calibrate absorbance readings to concentration.

Components: Store all materials at 4 °C:

• Standard peptide: 0.5 mL
• Standard diluent: 1.5 mL
• Microelisa Strip plate: 12 well x 8 strips
• 6 mL HRP-Conjugate Antibody
• 30 x wash solution with 25 mL
• 5 mL Sample diluent
• 5 mL Chromogen Solution A
• 5 mL Chromogen Solution B
• 5 mL Stop Solution
• Instruction Manual
• 2 Closure plate membrane
• Sealed bag

Material not included:

• 37 °C incubator
• Standard absorbance microplate reader
• Precision pipettes and disposable pipette tips
• De-ionized water
• Disposable tubes for sample dilution
• Absorbent paper

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for SNCA ELISA Kit (ABIN1059104)

Johnson, Drugan, Miller, Evans: "38" in: , Vol. 1363, Issue Nucleic acids research, pp. 28-39, (1991)

Target Details for SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: alpha-Synuclein (SNCA Products)

Synonyms: snca ELISA Kit, MGC64356 ELISA Kit, LOC619283 ELISA Kit, NACP ELISA Kit, alphaSYN ELISA Kit, PARK1 ELISA Kit, PARK4 ELISA Kit, PD1 ELISA Kit, synuclein alpha L homeolog ELISA Kit, alpha-synuclein ELISA Kit, synuclein alpha ELISA Kit, synuclein, alpha ELISA Kit, snca.L ELISA Kit, LOC619283 ELISA Kit, SNCA ELISA Kit, Snca ELISA Kit

Background: Alpha-synuclein (SNCA gene) is a 140 amino acid predominantly cytosolic protein expressed in brain associated with fibrillar structures in Lewy Bodies. Although primary located in the cytosol, alpha-synuclein binds to phospholipid and may assemble into pore-like structures in cellular membranes. Generation of aggregates in Lewy Bodies and/or association of alpha-synuclein with membraneous structures have been attributed to the etiology of Parkinson's Disease. Many additional cellular mechanisms associated with abnormal accumulations of alpha-synuclein in brain have also been proposed as underlying etiologies of the disease.
Parkinson's disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features of the disease include the characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies in brain and spinal cord.

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity