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- Target See all CPB2 ELISA Kits
- CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))
- Binding Specificity
- AA 1-423
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Reactivity
- Human
- Detection Method
- Colorimetric
- Method Type
- Sandwich ELISA
- Application
- ELISA
- Purpose
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human TAFI/CPB2
- Brand
- PicoKine™
- Analytical Method
- Quantitative
- Specificity
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Expression system for standard: NSO
Immunogen sequence: M1-V423 - Cross-Reactivity (Details)
- There is no detectable cross-reactivity with other relevant proteins.
- Characteristics
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Tissue Specificity: Plasma, synthesized in the liver.
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Carboxypeptidase B2 (Plasma) (CPB2) ELISA Kit
CPB2 Reactivity: Mouse Colorimetric Sandwich ELISA 0.31 ng/mL - 20 ng/mL Plasma
Carboxypeptidase B2 (Plasma) (CPB2) ELISA KitCPB2 Reactivity: Human Colorimetric Sandwich ELISA 0.31 ng/mL - 20 ng/mL Plasma
Carboxypeptidase B2 (Plasma) (CPB2) ELISA KitCPB2 Reactivity: Rat Colorimetric Sandwich ELISA 1.563 ng/mL - 100 ng/mL Plasma, Serum, Tissue Homogenate
Carboxypeptidase B2 (Plasma) (CPB2) ELISA KitCPB2 Reactivity: Human Colorimetric Sandwich ELISA 3.125 ng/mL - 200 ng/mL Plasma, Serum, Tissue Homogenate
Carboxypeptidase B2 (Plasma) (CPB2) ELISA KitCPB2 Reactivity: Mouse Colorimetric Sandwich ELISA 0.781 ng/mL - 50 ng/mL Plasma, Serum, Tissue Homogenate
Carboxypeptidase B2 (Plasma) (CPB2) ELISA KitCPB2 Reactivity: Human Colorimetric Sandwich ELISA 5 ng/mL - 320 ng/mL Cell Culture Supernatant, Plasma, Serum
Carboxypeptidase B2 (Plasma) (CPB2) ELISA KitCPB2 Reactivity: Horse Colorimetric Sandwich ELISA 3.125 ng/mL - 200 ng/mL Plasma, Serum, Tissue Homogenate
Carboxypeptidase B2 (Plasma) (CPB2) ELISA KitCPB2 Reactivity: Rat Colorimetric Sandwich ELISA 0.78 ng/mL - 50 ng/mL Plasma
Carboxypeptidase B2 (Plasma) (CPB2) ELISA KitCPB2 Reactivity: Human Colorimetric Competition ELISA 31.25-2000 ng/mL Plasma, Tissue Homogenate
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- Plate
- Pre-coated
- Restrictions
- For Research Use only
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- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- Expiry Date
- 12 months
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- Target See all CPB2 ELISA Kits
- CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))
- Alternative Name
- CPB2 (CPB2 Products)
- Background
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Protein Function: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. .
Background: Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.
Synonyms: Carboxypeptidase B2,3.4.17.20 ,Carboxypeptidase U,CPU,Plasma carboxypeptidase B,pCPB,Thrombin-activable fibrinolysis inhibitor,TAFI,CPB2,
Full Gene Name: Carboxypeptidase B2
Cellular Localisation: Secreted. - UniProt
- Q96IY4
- Pathways
- Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis
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