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LATS1 Products

(LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))

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The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

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Featured LATS1 Categories

LATS1 Antibodies

High quality antibodies with extensive validation data.

Recommended LATS1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IP, IF
Validations
  • (5)
Cat. No. ABIN7169059
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6262920
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
  • (1)
  • (2)
Cat. No. ABIN391033
Quantity 400 μL
Datasheet Datasheet

Recommended LATS1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968208
Quantity 96 tests
Datasheet Datasheet

Recommended LATS1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123723
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309191
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5508984
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our LATS1 products

Moon, Lee, Lee, Lee, Park, Park, Chang, Park, Choi: "STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle." in: Cells, Vol. 8, Issue 12, (2020) (PubMed).

Wigerius, Quinn, Diab, Clattenburg, Kolar, Qi, Krueger, Fawcett: "The polarity protein Angiomotin p130 controls dendritic spine maturation." in: The Journal of cell biology, Vol. 217, Issue 2, pp. 715-730, (2018) (PubMed).

Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." in: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).

Grijalva, Huizenga, Mueller, Rodriguez, Brazzo, Camargo, Sadri-Vakili, Vakili: "Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 307, Issue 2, pp. G196-204, (2014) (PubMed).

Chan, Lim, Guo, Tan, Leung, Hong: "Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation." in: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37296-307, (2013) (PubMed).

Huang, Nagatomo, Suzuki, Mizuno, Kumagai, Berezov, Zhang, Karlan, Greene, Wang: "YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14." in: Oncogene, Vol. 32, Issue 17, pp. 2220-9, (2013) (PubMed).

Salah, Melino, Aqeilan: "Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity." in: Cancer research, Vol. 71, Issue 5, pp. 2010-20, (2011) (PubMed).

Mao, Mulvaney, Zakaria, Yu, Morgan, Allen, Basson, Francis-West, Irvine: "Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development." in: Development (Cambridge, England), Vol. 138, Issue 5, pp. 947-57, (2011) (PubMed).

Oh, Lee, Kim, Kim, Oh, Hwang, Kong, Kwon, Lim: "Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse." in: Molecular and cellular biology, Vol. 29, Issue 23, pp. 6309-20, (2009) (PubMed).

Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis." in: Blood, Vol. 111, Issue 2, pp. 816-28, (2008) (PubMed).

Synonyms and alternative names related to LATS1

large tumor suppressor kinase 1 (LATS1), large tumor suppressor (Lats1), large tumor suppressor kinase 1 (lats1), large tumor suppressor kinase 1 (Lats1), large tumor suppressor kinase 1 S homeolog (lats1.S), AW208599, Lats, lats1, RGD1564085, si:dkey-181i3.5, WARTS, warts, wts, wu:fc19a11, zgc:123219

Protein level used designations for LATS1

  • LATS (large tumor suppressor, Drosophila) homolog 1
  • LATS, large tumor suppressor, homolog 1
  • WARTS protein kinase
  • h-warts
  • large tumor suppressor homolog 1
  • serine/threonine-protein kinase LATS1
  • large tumor supressor, homolog 1
  • large tumor suppressor 1
  • large tumor suppressor
  • LATS homolog 1
  • LATS, large tumor suppressor, homolog 1 (Drosophila)
  • serine/threonine-protein kinase LATS1-like
  • large tumor suppressor kinase 1 S homeolog
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