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Human Monoclonal CENPE Primary Antibody for ICC, FACS - ABIN108563
Yen, Compton, Wise, Zinkowski, Brinkley, Earnshaw, Cleveland: CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. in The EMBO journal 1991
Show all 10 Pubmed References
Human Monoclonal CENPE Primary Antibody for ICC, FACS - ABIN108562
Chang, Coughlin, Mitchison: Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. in Nature cell biology 2005
Show all 10 Pubmed References
Study demonstrates that KNL1 acts as a receptor of linear ubiquitin chains to anchor CENP-E at attached kinetochores. Thus, linear ubiquitin chains constitute a critical mechanism for chromosome congression and alignment by coupling the dynamic kinetochore microtubule motor CENP-E to the static one, the KMN network.
Results found that CENPE partial depletion induces aneuploidy in IMR90 human primary fibroblasts and in HCT116 cells.
CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases
SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores
CENP-E motor activity appears to play important roles in the organization of midbody proteins to complete cytokinetic abscission.
Data indicate that three genes, KIF14, NCAPG and CENPE that were upregulated in Pediatric high-grade gliomas (pHGGs) and were direct miR-137 or miR-6500-3p targets.
CENPE was regulated by the co-binding of LSD1 and AR to its promoter, which was associated with loss of RB1 in CRPC.
these results support a novel function of XAB2 in mitotic cell cycle regulation, which is partially mediated by transcription regulation on CENPE.
CTCF helps recruit CENP-E to the centromere during mitosis and that it may do so through a structure stabilized by the CTCF/CENP-E complex.
Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules.
CENP-Q - a subunit of the CENP-O complex (comprising CENP-O, CENP-P, CENP-Q and CENP-U) that targets polo-like kinase (Plk1) to kinetochores - is also required for the recruitment of CENP-E to kinetochores.
CENP-E-driven chromosome congression is guided by microtubule detyrosination.
CENP-E expression is highest in basal-like subtype among breast cancer patients.
An unexpected role of CENP-E elongated stalk in ensuring stability of kinetochore-microtubule attachments during chromosome congression and segregation.
dynein and CENP-E at kinetochores drive congression of peripheral polar chromosomes by preventing arm-ejection forces mediated by chromokinesins from working in the wrong direction.
Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism.
A CENP-E mediated wall-tethering event and a MCAK-mediated wall-removing event show that human chromosome-microtubule attachment is achieved through a set of deterministic sequential events rather than stochastic direct capture of microtubule ends.
The changes in ATP binding affinity and conformational deviations in human CENP-E motor domain, were studied.
Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips.
In this study we investigated the pathogenic effect of 132 nsSNPs reported in CENP-E using computational platform.
Exacerbating chromosome missegregation in CENP-E+/- mice by reducing levels of another mitotic checkpoint component, Mad2, results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.
CENP-E stabilises BubR1, thereby impacting meiosis I progression, and mediates bi-orientation by promoting kinetochore reorientation and preventing chromosomal drift towards the poles.
results suggest that CENP-E is implicated in the spindle checkpoint, and in chromosome alignment, during the two meiotic divisions in vertebrate males
Deletion of the mouse gene CENP-E causes unstable kinetochore-microtubule capture and chromosomal instability. (CENP-E)
Shugoshin 2 is necessary for the loading of MCAK at the inner centromere, but is dispensable for the loading of the outer kinetochore proteins BubR1 and CENP-E.
Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.
Centromere autoantigen E (312kD)
, centromere-associated protein E
, kinesin family member 10
, kinesin-related protein CENPE
, protein phosphatase 1, regulatory subunit 61
, N-7 kinesin
, centromere autoantigen E
, centromeric protein E
, kinesin 10
, kinesin superfamily protein 10
, motor domain of KIF10
, centromere protein E, 312kDa
, centromere protein E - 312kD