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anti-Human MAP3K11 Antibodies:
anti-Mouse (Murine) MAP3K11 Antibodies:
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Human Polyclonal MAP3K11 Primary Antibody for WB - ABIN4334888
Chien, Lin, Wang, Lee, Chen, Fong, Shih: Acacetin inhibits the invasion and migration of human non-small cell lung cancer A549 cells by suppressing the p38α MAPK signaling pathway. in Molecular and cellular biochemistry 2011
chronic hypoxia can reduce MLK3 expression in a posttranscriptional regulatory manner.
In lipotoxic hepatocytes, MLK3 activates a MAPK (show MAPK1 Antibodies) signaling cascade, resulting in the activating phosphorylation of STAT1 (show STAT1 Antibodies), and CXCL10 (show CXCL10 Antibodies) transcriptional upregulation.
Data indicate that BTG2 (show BTG2 Antibodies), MAP3K11, RPS6KA1 (show RPS6KA1 Antibodies) and PRDM1 (show PRDM1 Antibodies) as putative targets of microRNA miR (show MLXIP Antibodies)-125b.
Increased expression of MAP3K11 is associated with esophageal cancer.
During hepatocyte lipotoxicity, activated MLK3 induces the release of CXCL10 (show CXCL10 Antibodies)-bearing vesicles from hepatocytes, which are chemotactic for macrophages.
MLK3 serves as a common upstream kinase of AMPK (show PRKAA1 Antibodies) and JNK (show MAPK8 Antibodies) and functions as a direct upstream kinase for AMPK (show PRKAA1 Antibodies) independent of LKB1 (show STK11 Antibodies)
MLK3 represents a newly recognized integral component of HER2 (show ERBB2 Antibodies) biology in HER2 (show ERBB2 Antibodies)+ breast tumors.
MLK3 is a critical factor controlling the activity of kinase networks that control the cellular responses to different concentrations of reactive oxygen species.
Signaling pathways associated with the Pro252His mutation in MLK3 are located in the kinase domain which is an important domain for the regulation of downstream signaling pathways.
CHIP modulates MLK3 protein levels in response to Geldanamycin and stress stimuli, and CHIP-dependent regulation of MLK3 is required for suppression of SKOV3 ovarian cancer cell invasion.
In lipotoxic hepatocytes, MLK3 (show KCNK7 Antibodies) activates a MAPK (show MAPK1 Antibodies) signaling cascade, resulting in the activating phosphorylation of STAT1 (show STAT1 Antibodies), and CXCL10 (show CXCL10 Antibodies) transcriptional upregulation.
MAP3K11 might function as an important tumor suppressor neutralized by oncomiR-125b in B-cell leukemia.
During hepatocyte lipotoxicity, activated MLK3 (show KCNK7 Antibodies) induces the release of CXCL10 (show CXCL10 Antibodies)-bearing vesicles from hepatocytes, which are chemotactic for macrophages.
TRB3 (show TRIB3 Antibodies)(-/-) islets show a decrease in both the amplitude and duration of cytokine-stimulated MLK3 (show KCNK7 Antibodies) induction and JNK (show MAPK8 Antibodies) activation.
MLK3 (show KCNK7 Antibodies) limits RhoA (show RHOA Antibodies) activation and injury-induced neointima formation by binding to and inhibiting the activation of p63Rho guanine nucleotide exchange factor (show ARHGEF12 Antibodies), a RhoA (show RHOA Antibodies) activator.
Genetic or pharmacologic inhibition of MLK3 (show KCNK7 Antibodies) blocks fMLP (show FPR1 Antibodies)-mediated motility of neutrophils both in vitro and in vivo, suggesting that MLK3 (show KCNK7 Antibodies) may be a therapeutic target in human diseases characterized by exuberant neutrophil migration.
Data indicate URMC-099 as an orally bioavailable, potent mixed lineage kinase 3 MLK3 inhibitor.
Data from knockout mice suggest that MLK3 (show KCNK7 Antibodies) plays role in saturated fatty acid-induced activation of MAP kinase (show MAPK1 Antibodies) signaling; MLK3 (show KCNK7 Antibodies) appears to be involved in pathogenesis of obesity, adipose tissue in fl ammation, insulin (show INS Antibodies) resistance, and fatty liver disease.
Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 (show MAPK8IP1 Antibodies) scaffold protein (show HOMER1 Antibodies) in cytokine-induced pancreatic beta cell death
These results reveal a novel role for MLK3 (show KCNK7 Antibodies) signaling in the regulation of intestinal epithelial migration in vivo and suggest that MLK3 (show KCNK7 Antibodies) may be an important target for the regulation of intestinal mucosal healing.
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
SH3 domain-containing proline-rich kinase
, mixed lineage kinase 3
, protein-tyrosine kinase PTK1
, src-homology 3 domain-containing proline-rich kinase
, mitogen activated protein kinase kinase kinase 11