MAP3K11 antibody (AA 536-693)

Catalog No. ABIN7160017

Product Details anti-MAP3K11 Antibody

Target: MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11 (MAP3K11))

Binding Specificity: AA 536-693

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K11 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Mitogen-activated protein kinase kinase kinase 11 protein (536-693AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MAP3K11

Target: MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11 (MAP3K11))

Alternative Name: MAP3K11 (MAP3K11 Products)

Synonyms: MEKK11 antibody, MLK-3 antibody, MLK3 antibody, PTK1 antibody, SPRK antibody, 2610017K16Rik antibody, Mlk3 antibody, Mlk-3 antibody, RHOE antibody, mitogen-activated protein kinase kinase kinase 11 antibody, MAP3K11 antibody, Map3k11 antibody

Background:

Background: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

Aliases: 2610017K16Rik antibody, EC 2.7.11.25 antibody, M3K11_HUMAN antibody, Map3k11 antibody, MEKK11 antibody, MGC17114 antibody, Mitogen-activated protein kinase kinase kinase 11 antibody, Mixed lineage kinase 3 antibody, Mixed lineage protein kinase 3 antibody, Mlk-3 antibody, Mlk3 antibody, Protein tyrosine kinase PTK1 antibody, PTK1 antibody, RHOE antibody, SH3 domain containing proline rich kinase antibody, SPRK antibody, Src-homology 3 domain-containing proline-rich kinase antibody

UniProt: Q16584

Pathways: MAPK Signaling, Interferon-gamma Pathway