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anti-Human MAP3K12 Antibodies:
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Human Polyclonal MAP3K12 Primary Antibody for ELISA, WB - ABIN4332642
Douziech, Laberge, Grondin, Daigle, Blouin: Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999
Show all 6 Pubmed References
Human Polyclonal MAP3K12 Primary Antibody for IHC (p), WB - ABIN391319
Itoh, Wang, Ito, Reddy, Itoh: SP3 acts as a positive regulator on the core promoter of human ZPK gene. in Biochemical and biophysical research communications 2003
Show all 7 Pubmed References
Human Polyclonal MAP3K12 Primary Antibody for IHC, IHC (fro) - ABIN4332644
Welsbie, Mitchell, Jaskula-Ranga, Sluch, Yang, Kim, Buehler, Patel, Martin, Zhang, Ge, Duan, Fuller, Kim, Hamed, Chamling, Lei, Fraser, Ronai, Berlinicke, Zack: Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. in Neuron 2017
Human Polyclonal MAP3K12 Primary Antibody for IHC, IHC (p) - ABIN4332643
Itoh, Horiuchi, Ikeda, Xu, Bannerman, Pleasure, Penninger, Tournier, Itoh: ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
The expression of piRNAs encoded at DLK1 (show DLK1 Antibodies)-DIO3 (show DIO3 Antibodies) enhances the prognostic potential of small non-coding RNAs specific to this locus in predicting lung cancer patient outcome.
targeting DLK1 (show DLK1 Antibodies) might inhibit the tumor growth via initiating cell differentiation of hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cancer stem cell.
SASH1 (show SASH1 Antibodies) acts through NOTCH1 (show NOTCH1 Antibodies) and its inhibitor DLK1 (show DLK1 Antibodies) in a three-dimensional model of lumenogenesis involving CEACAM1 (show CEACAM1 Antibodies).
The data presented in this work suggest that a fine regulation of NOTCH (show NOTCH1 Antibodies) signaling BY DLK1 (show DLK1 Antibodies) plays an important role in the control of breast cancer cell proliferation and invasion.
results demonstrate that miR (show MLXIP Antibodies)-129-5p inhibits non-small cell lung cancer stemness and chemoresistance through direct targeting of DLK1 (show DLK1 Antibodies)
A complex defect of DLK1 (show DLK1 Antibodies) ( approximately 14-kb deletion and 269-bp duplication) was identified in a family with central precocious puberty. This deletion included the 5' untranslated region and the first exon of DLK1 (show DLK1 Antibodies), including the translational start site. Only family members who inherited the defect from their father have precocious puberty, consistent with the known imprinting of DLK1 (show DLK1 Antibodies).
Loss of DLK1 (show DLK1 Antibodies) expression is associated with fetal growth retardation complications of pregnancy.
LZK (show MAP3K13 Antibodies) cooperates with DLK (show DAPK3 Antibodies) to promote retinal ganglion cell death in response to axon injury.
In neonatal skin, DLK1 (show DLK1 Antibodies) exhibited a high degree of monoallelic expression from the paternal allele.
The study evaluated the roles of extracellular soluble DLK1 (show DLK1 Antibodies), comprising six EGF (show EGF Antibodies)-like domains and juxtamembrane regions, in human pancreatic cancer MIA (show MIA Antibodies) PaCa-2 cells in vitro and in vivo. Soluble DLK1 (show DLK1 Antibodies) exerted antitumor effects not only in cancer cell migration and anchorage-independent cell growth but also in in vivo tumor growth.
These findings identify DLK as a central regulator of not only JNK but also PERK stress signaling in neurons, with both pathways contributing to neurodegeneration.
Results provide the first evidence that axon guidance genes are downstream targets of the dual leucine zipper kinase (DLK) signaling pathway, which through their regulation probably modulates neuronal cell development, structure and function.
the prevention of the nuclear localization of DLK (show DAPK3 Antibodies) as induced by prediabetic signals with consecutive suppression of beta-cell apoptosis might constitute a novel target in the therapy of diabetes mellitus
Data assesses DLK's role in axons of adult, injured CNS neurons in vivo and shows that DLK (show DAPK3 Antibodies) does not appear to have a critical function in axonal degeneration; function appears restricted to soma
This study provides compelling evidence for the pivotal roles of the ZPK/DLK and MKK4/MAP2K4 (show MAP2K4 Antibodies)-dependent mechanism in axotomy-induced motoneuron death in neonates
DLK (show DAPK3 Antibodies)-inducible knockouts displayed a modest increase in basal synaptic transmission but had an attenuation of the JNK/c-Jun stress response pathway activation and significantly reduced neuronal degeneration after kainic acid-induced seizures.
Abundance of DLK (show DAPK3 Antibodies) in turn controlled the levels of downstream JNK (show MAPK8 Antibodies) signaling and apoptosis.
DLK (show DAPK3 Antibodies) is required for RGC JNK (show MAPK8 Antibodies) activation and cell death in a rodent model of optic neuropathy
The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. DLK (show DAPK3 Antibodies) is an essential upstream mediator of both of these divergent outcomes in the same cell type.
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
fetal antigen 1
, preadipocyte factor 1
, protein delta homolog 1
, MAPK-upstream kinase
, dual leucine zipper bearing kinase
, dual leucine zipper kinase DLK
, leucine zipper protein kinase
, mixed lineage kinase
, protein kinase MUK
, Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase)
, Zipper (leucine) protein kinase
, dual leucine zipper kinase
, leucine-zipper protein kinase
, mitogen-activated protein kinase kinase kinase 12
, mitogen activated protein kinase kinase kinase 12
, zipper (leucine) protein kinase
, mitogen activated protein kinase kinase kinase 12 type A
, mitogen activated protein kinase kinase kinase 12 type B
, mitogen-activated protein kinase kinase kinase 12 L homeolog