Browse our anti-MAP3K12 (MAP3K12) Antibodies

Full name:: anti-Mitogen-Activated Protein Kinase Kinase Kinase 12 Antibodies (MAP3K12)

On www.antibodies-online.com are 63 Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) Antibodies from 14 different suppliers available. Additionally we are shipping MAP3K12 Proteins (8) and many more products for this protein. A total of 76 MAP3K12 products are currently listed.

Synonyms:: DKFZp459K2433, dlk, map3k12, map3k12-a, map3k12-b, map3k12a, map3k12b, mekk12, MGC151798, muk, PK, zgc:77370, zpk, zpkp1

list all antibodies	Gene Name	GeneID	UniProt
	MAP3K12	7786	Q12852
	MAP3K12	25579	Q63796
	MAP3K12	26404	Q60700
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Most Popular Reactivities for anti-MAP3K12 (MAP3K12) Antibodies

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anti-Human MAP3K12 Antibodies:

anti-Rat (Rattus) MAP3K12 Antibodies:

anti-Mouse (Murine) MAP3K12 Antibodies:

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Relevant Pathways for anti-MAP3K12 Antibodies

MAPK Signaling

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Top referenced anti-MAP3K12 Antibodies

Human Polyclonal MAP3K12 Primary Antibody for ELISA, WB - ABIN4332642 : Douziech, Laberge, Grondin, Daigle, Blouin: Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 (PubMed)
Show all 6 Pubmed References
Human Polyclonal MAP3K12 Primary Antibody for IHC (p), WB - ABIN391319 : Itoh, Wang, Ito, Reddy, Itoh: SP3 acts as a positive regulator on the core promoter of human ZPK gene. in Biochemical and biophysical research communications 2003 (PubMed)
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Human Polyclonal MAP3K12 Primary Antibody for IHC, IHC (fro) - ABIN4332644 : Welsbie, Mitchell, Jaskula-Ranga, Sluch, Yang, Kim, Buehler, Patel, Martin, Zhang, Ge, Duan, Fuller, Kim, Hamed, Chamling, Lei, Fraser, Ronai, Berlinicke, Zack: Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. in Neuron 2017 (PubMed)
Human Polyclonal MAP3K12 Primary Antibody for IHC, IHC (p) - ABIN4332643 : Itoh, Horiuchi, Ikeda, Xu, Bannerman, Pleasure, Penninger, Tournier, Itoh: ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 (PubMed)

More Antibodies against MAP3K12 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) interaction partners

LZK (show MAP3K13 Antibodies) cooperates with DLK (show DAPK3 Antibodies) to promote retinal ganglion cell death in response to axon injury.
REVIEW: Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase
miR (show MLXIP Antibodies)-130a inhibited the JNK (show MAPK8 Antibodies) pathway by targeting MAP3K12, contributing to its anti-apoptotic effect and the maintenance of diabetic endothelial progenitor cell function.
Data suggest that specific pharmacological inhibition of dual leucine zipper kinase (DLK, MAP3K12) may have therapeutic potential in multiple indications of neuronal degeneration.
these findings indicate that DLK (show DAPK3 Antibodies) participates in cell proliferation and/or survival, at least in part, by modulating the expression of cell cycle regulatory proteins.
The results confirm the significance of apoptosis deregulation in CLL, and suggest a possible relationship between ZIPK (show DAPK3 Antibodies) expression and the clinical course of the disease.
the DLK (show DAPK3 Antibodies)-ERK (show EPHB2 Antibodies) signaling pathway may act as a regulator of the interaction that occurs between Hsp27 (show HSPB1 Antibodies) and the cytoskeleton during the formation of the cornified cell envelope, a process conferring to the skin its crucial barrier function
for the selective expression of ZPK gene, cell-specific negative regulatory element(s) which locate outside of the core promoter region repress the potent basic promoter activity
ZIPK (show DAPK3 Antibodies) is positively regulated by phosphorylation within its kinase domain and contains an inhibitory C-terminal domain that controls enzyme activity.
DLK (show DAPK3 Antibodies) is a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) interaction partners

These findings demonstrate that pathological activation of DLK (show DAPK3 Antibodies) is a conserved mechanism that regulates neurodegeneration.
These findings identify DLK as a central regulator of not only JNK but also PERK stress signaling in neurons, with both pathways contributing to neurodegeneration.
Results provide the first evidence that axon guidance genes are downstream targets of the dual leucine zipper kinase (DLK) signaling pathway, which through their regulation probably modulates neuronal cell development, structure and function.
LZK (show MAP3K13 Antibodies) cooperates with DLK (show DAPK3 Antibodies) to promote retinal ganglion cell death in response to axon injury.
the prevention of the nuclear localization of DLK (show DAPK3 Antibodies) as induced by prediabetic signals with consecutive suppression of beta-cell apoptosis might constitute a novel target in the therapy of diabetes mellitus
Data assesses DLK's role in axons of adult, injured CNS neurons in vivo and shows that DLK (show DAPK3 Antibodies) does not appear to have a critical function in axonal degeneration; function appears restricted to soma
This study provides compelling evidence for the pivotal roles of the ZPK/DLK and MKK4/MAP2K4 (show MAP2K4 Antibodies)-dependent mechanism in axotomy-induced motoneuron death in neonates
DLK (show DAPK3 Antibodies)-inducible knockouts displayed a modest increase in basal synaptic transmission but had an attenuation of the JNK/c-Jun stress response pathway activation and significantly reduced neuronal degeneration after kainic acid-induced seizures.
Abundance of DLK (show DAPK3 Antibodies) in turn controlled the levels of downstream JNK (show MAPK8 Antibodies) signaling and apoptosis.
DLK (show DAPK3 Antibodies) is required for RGC JNK (show MAPK8 Antibodies) activation and cell death in a rodent model of optic neuropathy

MAP3K12 Antigen Profile

Antigen Summary

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.

Alternative names and synonyms associated with MAP3K12

mitogen-activated protein kinase kinase kinase 12 (MAP3K12) antibody
mitogen activated protein kinase kinase kinase 12 (Map3k12) antibody
mitogen-activated protein kinase kinase kinase 12 (Map3k12) antibody
mitogen-activated protein kinase kinase kinase 12 (map3k12) antibody
mitogen-activated protein kinase kinase kinase 12 S homeolog (map3k12.S) antibody
mitogen-activated protein kinase kinase kinase 12 L homeolog (map3k12.L) antibody

DKFZp459K2433 antibody
dlk antibody
map3k12 antibody
map3k12-a antibody
map3k12-b antibody
map3k12a antibody
map3k12b antibody
mekk12 antibody
MGC151798 antibody
muk antibody
PK antibody
zgc:77370 antibody
zpk antibody
zpkp1 antibody

Protein level used designations for MAP3K12

MAPK-upstream kinase , dual leucine zipper bearing kinase , dual leucine zipper kinase DLK , leucine zipper protein kinase , mixed lineage kinase , protein kinase MUK , Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase) , Zipper (leucine) protein kinase , dual leucine zipper kinase , leucine-zipper protein kinase , mitogen-activated protein kinase kinase kinase 12 , mitogen activated protein kinase kinase kinase 12 , zipper (leucine) protein kinase , mitogen activated protein kinase kinase kinase 12 type A , mitogen activated protein kinase kinase kinase 12 type B , mitogen-activated protein kinase kinase kinase 12 L homeolog

GENE ID	SPECIES
7786	Homo sapiens
25579	Rattus norvegicus
26404	Mus musculus
404626	Danio rerio
451940	Pan troglodytes
505427	Bos taurus
607170	Canis lupus familiaris
703059	Macaca mulatta
100064002	Equus caballus
100113430	Xenopus laevis
100172208	Pongo abelii
100358158	Oryctolagus cuniculus
100408788	Callithrix jacchus
100469942	Ailuropoda melanoleuca
100517714	Sus scrofa
100337576	Xenopus laevis

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Show all anti-Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) Antibodies with Pubmed References

Human Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) interaction partners

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) interaction partners

Antigen Summary

Alternative names and synonyms associated with MAP3K12

Protein level used designations for MAP3K12