Browse our anti-MAP3K12 (MAP3K12) Antibodies

Full name:: anti-Mitogen-Activated Protein Kinase Kinase Kinase 12 Antibodies (MAP3K12)

On www.antibodies-online.com are 59 Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) Antibodies from 14 different suppliers available. Additionally we are shipping MAP3K12 Proteins (7) and many more products for this protein. A total of 71 MAP3K12 products are currently listed.

Synonyms:: Delta1, DKFZp459K2433, dlk, DLK-1, FA1, map3k12, map3k12-a, map3k12-b, map3k12a, map3k12b, mekk12, MGC151798, muk, pG2, PK, Pref-1, PREF1, zgc:77370, ZOG, zpk, zpkp1

list all antibodies	Gene Name	GeneID	UniProt
	MAP3K12	8788	P80370
	MAP3K12	25579	Q63796
	MAP3K12	26404	Q60700
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Most Popular Reactivities for anti-MAP3K12 (MAP3K12) Antibodies

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anti-Human MAP3K12 Antibodies:

anti-Rat (Rattus) MAP3K12 Antibodies:

12 WB Antibodies

anti-Mouse (Murine) MAP3K12 Antibodies:

22 WB Antibodies

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Relevant Pathways for anti-MAP3K12 Antibodies

MAPK Signaling

More product categories related to MAP3K12 Antibody

Top referenced anti-MAP3K12 Antibodies

Human Polyclonal MAP3K12 Primary Antibody for ELISA, WB - ABIN4332642 : Douziech, Laberge, Grondin, Daigle, Blouin: Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 (PubMed)
Show all 6 Pubmed References
Human Polyclonal MAP3K12 Primary Antibody for IHC (p), WB - ABIN391319 : Itoh, Wang, Ito, Reddy, Itoh: SP3 acts as a positive regulator on the core promoter of human ZPK gene. in Biochemical and biophysical research communications 2003 (PubMed)
Show all 7 Pubmed References
Human Polyclonal MAP3K12 Primary Antibody for IHC, IHC (fro) - ABIN4332644 : Welsbie, Mitchell, Jaskula-Ranga, Sluch, Yang, Kim, Buehler, Patel, Martin, Zhang, Ge, Duan, Fuller, Kim, Hamed, Chamling, Lei, Fraser, Ronai, Berlinicke, Zack: Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. in Neuron 2017 (PubMed)
Human Polyclonal MAP3K12 Primary Antibody for IHC, IHC (p) - ABIN4332643 : Itoh, Horiuchi, Ikeda, Xu, Bannerman, Pleasure, Penninger, Tournier, Itoh: ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 (PubMed)

More Antibodies against MAP3K12 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) interaction partners

The expression of piRNAs encoded at DLK1 (show DLK1 Antibodies)-DIO3 (show DIO3 Antibodies) enhances the prognostic potential of small non-coding RNAs specific to this locus in predicting lung cancer patient outcome.
targeting DLK1 (show DLK1 Antibodies) might inhibit the tumor growth via initiating cell differentiation of hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cancer stem cell.
SASH1 (show SASH1 Antibodies) acts through NOTCH1 (show NOTCH1 Antibodies) and its inhibitor DLK1 (show DLK1 Antibodies) in a three-dimensional model of lumenogenesis involving CEACAM1 (show CEACAM1 Antibodies).
The data presented in this work suggest that a fine regulation of NOTCH (show NOTCH1 Antibodies) signaling BY DLK1 (show DLK1 Antibodies) plays an important role in the control of breast cancer cell proliferation and invasion.
results demonstrate that miR (show MLXIP Antibodies)-129-5p inhibits non-small cell lung cancer stemness and chemoresistance through direct targeting of DLK1 (show DLK1 Antibodies)
A complex defect of DLK1 (show DLK1 Antibodies) ( approximately 14-kb deletion and 269-bp duplication) was identified in a family with central precocious puberty. This deletion included the 5' untranslated region and the first exon of DLK1 (show DLK1 Antibodies), including the translational start site. Only family members who inherited the defect from their father have precocious puberty, consistent with the known imprinting of DLK1 (show DLK1 Antibodies).
Loss of DLK1 (show DLK1 Antibodies) expression is associated with fetal growth retardation complications of pregnancy.
LZK (show MAP3K13 Antibodies) cooperates with DLK (show DAPK3 Antibodies) to promote retinal ganglion cell death in response to axon injury.
In neonatal skin, DLK1 (show DLK1 Antibodies) exhibited a high degree of monoallelic expression from the paternal allele.
The study evaluated the roles of extracellular soluble DLK1 (show DLK1 Antibodies), comprising six EGF (show EGF Antibodies)-like domains and juxtamembrane regions, in human pancreatic cancer MIA (show MIA Antibodies) PaCa-2 cells in vitro and in vivo. Soluble DLK1 (show DLK1 Antibodies) exerted antitumor effects not only in cancer cell migration and anchorage-independent cell growth but also in in vivo tumor growth.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) interaction partners

These findings identify DLK as a central regulator of not only JNK but also PERK stress signaling in neurons, with both pathways contributing to neurodegeneration.
Results provide the first evidence that axon guidance genes are downstream targets of the dual leucine zipper kinase (DLK) signaling pathway, which through their regulation probably modulates neuronal cell development, structure and function.
LZK (show MAP3K13 Antibodies) cooperates with DLK (show DAPK3 Antibodies) to promote retinal ganglion cell death in response to axon injury.
the prevention of the nuclear localization of DLK (show DAPK3 Antibodies) as induced by prediabetic signals with consecutive suppression of beta-cell apoptosis might constitute a novel target in the therapy of diabetes mellitus
Data assesses DLK's role in axons of adult, injured CNS neurons in vivo and shows that DLK (show DAPK3 Antibodies) does not appear to have a critical function in axonal degeneration; function appears restricted to soma
This study provides compelling evidence for the pivotal roles of the ZPK/DLK and MKK4/MAP2K4 (show MAP2K4 Antibodies)-dependent mechanism in axotomy-induced motoneuron death in neonates
DLK (show DAPK3 Antibodies)-inducible knockouts displayed a modest increase in basal synaptic transmission but had an attenuation of the JNK/c-Jun stress response pathway activation and significantly reduced neuronal degeneration after kainic acid-induced seizures.
Abundance of DLK (show DAPK3 Antibodies) in turn controlled the levels of downstream JNK (show MAPK8 Antibodies) signaling and apoptosis.
DLK (show DAPK3 Antibodies) is required for RGC JNK (show MAPK8 Antibodies) activation and cell death in a rodent model of optic neuropathy
The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. DLK (show DAPK3 Antibodies) is an essential upstream mediator of both of these divergent outcomes in the same cell type.

MAP3K12 Antigen Profile

Antigen Summary

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.

Alternative names and synonyms associated with MAP3K12

delta like non-canonical Notch ligand 1 (DLK1) antibody
mitogen-activated protein kinase kinase kinase 12 (MAP3K12) antibody
mitogen activated protein kinase kinase kinase 12 (Map3k12) antibody
mitogen-activated protein kinase kinase kinase 12 (Map3k12) antibody
mitogen-activated protein kinase kinase kinase 12 (map3k12) antibody
mitogen-activated protein kinase kinase kinase 12 S homeolog (map3k12.S) antibody
mitogen-activated protein kinase kinase kinase 12 L homeolog (map3k12.L) antibody

Delta1 antibody
DKFZp459K2433 antibody
dlk antibody
DLK-1 antibody
FA1 antibody
map3k12 antibody
map3k12-a antibody
map3k12-b antibody
map3k12a antibody
map3k12b antibody
mekk12 antibody
MGC151798 antibody
muk antibody
pG2 antibody
PK antibody
Pref-1 antibody
PREF1 antibody
zgc:77370 antibody
ZOG antibody
zpk antibody
zpkp1 antibody

Protein level used designations for MAP3K12

, , , , , , , , , , , , , , , , , , , fetal antigen 1 preadipocyte factor 1 protein delta homolog 1 secredeltin MAPK-upstream kinase dual leucine zipper bearing kinase dual leucine zipper kinase DLK leucine zipper protein kinase mixed lineage kinase protein kinase MUK Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase) Zipper (leucine) protein kinase dual leucine zipper kinase leucine-zipper protein kinase mitogen-activated protein kinase kinase kinase 12 mitogen activated protein kinase kinase kinase 12 zipper (leucine) protein kinase mitogen activated protein kinase kinase kinase 12 type A mitogen activated protein kinase kinase kinase 12 type B mitogen-activated protein kinase kinase kinase 12 L homeolog

GENE ID	SPECIES
8788	Homo sapiens
7786	Homo sapiens
25579	Rattus norvegicus
26404	Mus musculus
404626	Danio rerio
451940	Pan troglodytes
505427	Bos taurus
607170	Canis lupus familiaris
703059	Macaca mulatta
100064002	Equus caballus
100113430	Xenopus laevis
100172208	Pongo abelii
100358158	Oryctolagus cuniculus
100408788	Callithrix jacchus
100469942	Ailuropoda melanoleuca
100517714	Sus scrofa
100337576	Xenopus laevis

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Show all anti-Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) Antibodies with Pubmed References

Human Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) interaction partners

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) interaction partners

Antigen Summary

Alternative names and synonyms associated with MAP3K12

Protein level used designations for MAP3K12