Mitogen-Activated Protein Kinase Kinase Kinase 3 Products
(Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))
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This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively\; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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Featured Mitogen-Activated Protein Kinase Kinase Kinase 3 Categories
Mitogen-Activated Protein Kinase Kinase Kinase 3 Antibodies
High quality antibodies with extensive validation data.
Mitogen-Activated Protein Kinase Kinase Kinase 3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Mitogen-Activated Protein Kinase Kinase Kinase 3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN7268652
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (3)
Cat. No.
ABIN7258882
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IHC (p)
Validations
- (4)
Cat. No.
ABIN3044008
Quantity
100 μg
Datasheet
Datasheet
Recommended Mitogen-Activated Protein Kinase Kinase Kinase 3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7549217
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7557662
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310214
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Mitogen-Activated Protein Kinase Kinase Kinase 3 products
: "Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways." in: Anticancer research, Vol. 30, Issue 6, pp. 2135-43, (2010) (PubMed).: "PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 36989-92, (2003) (PubMed).
: "Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3." in: Nature immunology, Vol. 5, Issue 1, pp. 98-103, (2003) (PubMed).
: "Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock." in: Nature cell biology, Vol. 5, Issue 12, pp. 1104-10, (2003) (PubMed).
: "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 ..." in: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2668-74, (1997) (PubMed).
Synonyms and alternative names related to Mitogen-Activated Protein Kinase Kinase Kinase 3
mitogen-activated protein kinase kinase kinase 3 (MAP3K3), mitogen-activated protein kinase kinase kinase 3 (Map3k3), mitogen activated protein kinase kinase kinase 3 (Map3k3), mitogen-activated protein kinase kinase kinase 3 (map3k3), mitogen-activated protein kinase kinase kinase 3 L homeolog (map3k3.L), NPK1-related protein kinase 3 (NP3), ANP3, AtANP3, AW548911, F24F17.1, F24F17_1, map3k3, MAPKKK3, mapkkk3, MAPKKK12, MEKK3, Mekk3, mekk3, mKIAA4031, NPK1-related protein kinase 3Protein level used designations for Mitogen-Activated Protein Kinase Kinase Kinase 3
- MAP/ERK kinase kinase 3
- MAPK/ERK kinase kinase 3
- MEK kinase 3
- MEKK 3
- mitogen activated protein kinase kinase kinase 3
- mitogen-activated protein kinase kinase kinase 3
- mitogen-activated protein kinase kinase kinase 3 L homeolog
- Arabidopsis NPK1-related protein kinase 3
Did you look for something else?
- Mitogen-Activated Protein Kinase Kinase Kinase 13
- Mitogen-Activated Protein Kinase Kinase 4
- Mitogen-Activated Protein Kinase Kinase 2
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase
- Mitochondrially Encoded NADH Dehydrogenase 4
- Mitochondrially Encoded ATP Synthase 8
- Mitochondrial Translation Elongation Factor EF-Ts Tsf1
- Mitochondrial Import Receptor Subunit TOM20 homolog
- Mitochondrial E3 Ubiquitin Protein Ligase 1
- Mitochondrial ATPase Subunit 8
- MITF
- MITD1
- Mismatch Repair Protein 2
- MIS18 Binding Protein 1
- MIS12
- MIR7-3HG
- MIR22HG
- MIPOL1
- MIPEP
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