Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Rat (Rattus) TNFRSF11A Antibodies:
anti-Mouse (Murine) TNFRSF11A Antibodies:
anti-Human TNFRSF11A Antibodies:
Go to our pre-filtered search.
Human Monoclonal TNFRSF11A Primary Antibody for CyTOF, FACS - ABIN252472
Fiumara, Snell, Li, Mukhopadhyay, Younes, Gillenwater, Cabanillas, Aggarwal, Younes: Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines. in Blood 2001
Show all 15 Pubmed References
Human Monoclonal TNFRSF11A Primary Antibody for FACS, IHC (p) - ABIN252036
Lee, Kim, Jun, Yoo, Woo, Choi, Lee, Song, Sohn, Park-Min, Ivashkiv, Ji: Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta. in Journal of immunology (Baltimore, Md. : 1950) 2010
Show all 10 Pubmed References
Human Monoclonal TNFRSF11A Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900544
Vernal, Dutzan, Hernández, Chandía, Puente, León, García, Del Valle, Silva, Gamonal: High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4+ T lymphocytes. in Journal of periodontology 2006
Show all 8 Pubmed References
Mouse (Murine) Monoclonal TNFRSF11A Primary Antibody for FACS, IP - ABIN2479562
García-Pérez, Noguera, Hermenegildo, Martínez-Romero, Tarín, Cano: Alterations in the phenotype and function of immune cells in ovariectomy-induced osteopenic mice. in Human reproduction (Oxford, England) 2006
Human Monoclonal TNFRSF11A Primary Antibody for FACS - ABIN4897927
Riegel, Maurer, Prior, Stegmaier, Heppert, Wagner, Hänsch: Human polymorphonuclear neutrophils express RANK and are activated by its ligand, RANKL. in European journal of immunology 2012
RANK deficiency ameliorates podocyte injury by suppressing calcium/calcineurin/NFATc1 (show NFATC1 Antibodies) signaling
TNFalpha and RANKL promote osteoclastogenesis by upregulating RANK via the NFkappaB pathway.
Results from this study demonstrate that RANK signalling in NPY (show NPY Antibodies) neurons is involved in modulating NPY (show NPY Antibodies) levels and through that matching bone mass to body weight.
the investigation of RANK and RANKL (show TNFSF11 Antibodies) as possible novel immunotherapy targets in cancer is a rational approach. Here we have defined the mechanism of action of RANKL (show TNFSF11 Antibodies)-RANK blockade in combination with anti-CTLA4 (show CTLA4 Antibodies), and provide insight into the combination efficacy observed in the case reports.
Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
This indicated that RANK might be the binding target of baicalin. In sum, our findings revealed baicalin increased osteoclast maturation and function via p-ERK (show EPHB2 Antibodies)/Mitf (show MITF Antibodies) signalling. In addition, the results suggest that baicalin can potentially be used as a natural product for the treatment of bone fracture
RANKL (show TNFSF11 Antibodies)/RANK control progenitor cell expansion and tumorigenesis in inherited breast cancer.
Artesunate inhibits RANKL (show TNFSF11 Antibodies)-induced osteoclastogenesis by suppressing the NF-kappaB (show NFKB1 Antibodies) signaling pathway.
Data suggest that mutations at position I248 in DE-loop of murine RANKL (show TNFSF11 Antibodies) have effects on interaction of RANKL (show TNFSF11 Antibodies) with RANK and on subsequent activation of osteoclastogenesis by this hetero-multimer. (RANKL (show TNFSF11 Antibodies) = osteoclast differentiation factor (show TNFSF11 Antibodies); RANK = tumor necrosis factor (show TNF Antibodies) receptor superfamily, member 11a protein)
The persistence of bone erosion and synovial osteoclasts in Rank-deficient mice, and the ability of TNF (show TNF Antibodies)/IL-6 (show IL6 Antibodies) to induce osteoclastogenesis, suggest that more than one cytokine pathway exists to generate these bone-resorbing cells in inflamed joints.
gammadelta T cells suppressed iDCs osteoclastogenesis by downregulation of the RANK/cFos/ATP6V0D2 (show ATP6V0D2 Antibodies) signaling pathway.
study identified the second disease gene for DOS. TNFRSF11A isoforms may have the different roles in skeletal development and metabolism
The mRNA expression of RANK was highest in prostate tumour tissue from patients with bone metastases as compared to BPH or locally confined tumours, also shown in clinical subgroups distinguished by Gleason Score or PSA level.
For the RANK gene, the AGTGC haplotype was associated with the lowest risk of presenting chronic joint pain in individuals without TMD (show TTN Antibodies) (P=0.03). This study supports the hypothesis that changes in the OPG (show TNFRSF11B Antibodies) and RANK genes influence the presence of chronic joint pain in individuals with and without TMD (show TTN Antibodies).
In this study, whole exome sequencing (WES) was successfully used in six patients with malignant infantile osteopetrosis (show CSF1 Antibodies) (MIOP) and identified mutations in four MIOP-related genes (CLCN7 (show CLCN7 Antibodies), TCIRG1 (show TCIRG1 Antibodies), SNX10 (show SNX10 Antibodies), and TNFRSF11A).
triple-negative breast cancer (TNBC) patients that expressed both RANK and RANKL (show TNFSF11 Antibodies) proteins had significantly worse RFS and OS than patients with RANK-positive, RANKL (show TNFSF11 Antibodies)-negative tumors. RANKL (show TNFSF11 Antibodies) was an independent, poor prognostic factor for RFS and OS in multivariate analysis in samples that expressed both RANK and RANKL (show TNFSF11 Antibodies).
RANK is increased in hormone receptor (show NR4A1 Antibodies) negative and basal breast cancer, and correlates with worse recurrence-free survival and risk of bone metastasis.
Studies showed that the central hypothalamic-pituitary regulatory system, via it's relative hormones, seems to control OPG/RANKL (show TNFSF11 Antibodies)/RANK system function, and the pulsatility and circadian rhythmicity of these hormones may induce an oscillatory fluctuation of the OPG/ RANKL (show TNFSF11 Antibodies) ratio. Also, psycological characteristics may provoke a shift of the OPG/ RANKL (show TNFSF11 Antibodies) ratio towards an unbalanced or a balanced status. [review]
Studies strongly implicates RANK and RANKL as key molecules involved in the initiation of BRCA1-associated breast cancer. [review]
RANK is frequently expressed by cancer cells in contrast with RANKL (show TNFSF11 Antibodies) which is frequently detected in the tumor microenvironment, and together they participate in every step in cancer development. (Review)
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.
tumor necrosis factor receptor superfamily member 11A
, tumor necrosis factor receptor superfamily, member 11a, NFKB activator
, receptor activator of nuclear factor-kappa B
, tumor necrosis factor receptor superfamily member 11A-like
, osteoclast differentiation factor receptor
, receptor activator of NF-KB
, receptor activator of NF-kappaB
, loss of heterozygosity, 18, chromosomal region 1