NSD1 Products
(Nuclear Receptor Binding SET Domain Protein 1 (NSD1))
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This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
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NSD1 Antibodies
High quality antibodies with extensive validation data.
Recommended NSD1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (2)
Cat. No.
ABIN528606
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
- (2)
Cat. No.
ABIN872593
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (1)
Cat. No.
ABIN7191723
Quantity
100 μL
Datasheet
Datasheet
Recommended NSD1 Proteins
Latest Publications for our NSD1 products
: "The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells." in: Molecular cell, Vol. 70, Issue 2, pp. 371-379.e5, (2018) (PubMed).: "Community resources and technologies developed through the NIH Roadmap Epigenomics Program." in: Methods in molecular biology (Clifton, N.J.), Vol. 1238, pp. 27-49, (2014) (PubMed).
: "A transposon-based analysis of gene mutations related to skin cancer development." in: The Journal of investigative dermatology, Vol. 133, Issue 1, pp. 239-48, (2013) (PubMed).
: "Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 1, pp. 46-51, (2010) (PubMed).
Synonyms and alternative names related to NSD1
nuclear receptor binding SET domain protein 1 (NSD1), nuclear receptor binding SET domain protein 1 (nsd1), nuclear receptor binding SET domain protein 1 (Nsd1), histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (LOC540197), nuclear receptor-binding SET-domain protein 1 (Nsd1), AI528500, ara267, ARA267, kmt3b, KMT3B, NSD1, sotos, SOTOS, SOTOS1, sto, STOProtein level used designations for NSD1
- nuclear receptor binding SET domain protein 1
- histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific-like
- H3-K36-HMTase
- H4-K20-HMTase
- NR-binding SET domain-containing protein
- androgen receptor coactivator 267 kDa protein
- androgen receptor-associated coregulator 267
- androgen receptor-associated protein of 267 kDa
- histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
- lysine N-methyltransferase 3B
- nuclear receptor-binding SET domain-containing protein 1
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