Browse our anti-PPID (PPID) Antibodies

Human Peptidylprolyl Isomerase D (PPID) interaction partners

1. Binding of signal transducer and activator of transcription 3 (STAT3) to cyclophilin D (CypD) was important for reducing mitochondrial reactive oxygen species (ROS) production after oxidative stress.

2. Data show that cyclophilin 40 (CyP40) interacts with and dissolves amyloids forming proteins tau and alpha-synuclein aggregates.

3. This review discusses previous studies to provide comprehensive information on the physiological role of cyclophilin D as well as PTP opening in the cell that can be taken into consideration for the development of new PTP inhibitors. [review]

4. The influx of unfolded p53 (show TP53 Antibodies) into the mitochondrial matrix in response to oxidative stress indirectly activates the normally inhibited CypD by displacing it from Trap1 (show TRAP1 Antibodies) complexes. This activates CypD's isomerase activity. Liberated CypD then isomerizes multiple proteins including p53 (show TP53 Antibodies) (causing p53 (show TP53 Antibodies) aggregation) and the structural components of the mPTP (show PTPN2 Antibodies) pore, inducing pore opening.

5. The present study is to investigate the role of CypD in regulating the mitochondrial dynamics relevant to oxidative stress induced (show SQSTM1 Antibodies) neuron dysfunctions.

6. CyPD regulates mitochondrial metabolism, and likely cell survival, by promoting more efficient electrons flow through the respiratory chain via increased supercomplex formation

7. cyclophilin D may modify mitochondrial features by inducing the translocation of molecules to the mitochondria through the mechanism associated with cellular energy metabolism

8. The thermodynamics of binding of Cyp-40 to Hsp90 (show HSP90 Antibodies) shows remarkable temperature sensitivity in the physiological temperature range.

9. cyclophilin-D protein could increase oxidative stress and cause endothelial cell injury and apoptosis. cyclophilin-D protein is the key factor in reactive oxygen species-induced mitochondrial damage, leading to apoptosis of endothelial cells.

10. Results show that CypD interacts with SPG7 and VDAC to form the mitochondrial permeability transition pore complex (PTP)and its CsA-binding region is necessary for PTP formation.

Cow (Bovine) Peptidylprolyl Isomerase D (PPID) interaction partners

1. LKT-mediated cell death involve dynamin-2 and cyclophilin D.

Mouse (Murine) Peptidylprolyl Isomerase D (PPID) interaction partners

1. Data suggest that mitochondrial functions in osteoblasts during osteogenesis are regulated, in part, by CypD-mPTP (show PTPN2 Antibodies) axis; CypD appears to contribute to mitochondrial dysfunction in bone inflammation via excessive opening of mPTP (show PTPN2 Antibodies). (CypD = cyclophilin D (show PPIF Antibodies); mPTP (show PTPN2 Antibodies) = mitochondrial permeability transition pore)

2. Estrogen receptor beta (show ESR2 Antibodies) modulates mitochondrial permeability transition by regulating CypD interaction with OSCP (show ATP5O Antibodies).

3. CypD regulates complex I-induced ROS (show ROS1 Antibodies) production in heart mitochondria and modulates the cardioprotective effect of isoflurane, sevoflurane, and desflurane.

4. Murine eosinophil necrosis is regulated in vitro and in vivo by cyclophilin D.

5. Suggest that cyclosporin A-mediated CypD inhibition may provide a promising therapeutic potential for protecting retinal ganglion cells against ischemic injury-mediated mitochondrial dysfunction.

6. Loss of CypD results in changes in a number of mitochondrial proteins and metabolic pathways.

7. CypD directs mitochondria-to-nuclei inflammatory gene expression in normal and tumor cells

8. BAX/BAK-independent cell death did not require Cyclophilin D (CypD) expression, an important regulator of the mitochondrial permeability transition pore

9. At the whole muscle level, lack of cyclophilin-D does not protect against muscle atrophy, release of mitochondrial pro-apoptotic factors and activation of caspases following denervation.

10. mitochondrial permeability transition was increased by hypoxia-reoxygenation but was less in normoxic and hypoxia-reoxygenation Ppif(-/-) than wild type tubules