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OTC Products

(Ornithine Carbamoyltransferase (OTC))
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008].

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Featured OTC Categories

OTC Antibodies

High quality antibodies with extensive validation data.

OTC ELISA Kits

Reliable ELISA kits for a wide range of species.

OTC Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended OTC Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (9)
Cat. No. ABIN7433690
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN7264888
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (4)
Cat. No. ABIN6145081
Quantity 100 μL
Datasheet Datasheet

Recommended OTC ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969077
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962951
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958320
Quantity 96 tests
Datasheet Datasheet

Recommended OTC Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124272
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124271
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313731
Quantity 2 μg
Datasheet Datasheet

Latest Publications for our OTC products

Tarasenko, Rosas, Singh, Kristaponis, Vernon, McGuire: "A new mouse model of mild ornithine transcarbamylase deficiency (spf-j) displays cerebral amino acid perturbations at baseline and upon systemic immune activation." in: PLoS ONE, Vol. 10, Issue 2, pp. e0116594, (2015) (PubMed).

McGuire, Tarasenko, Wang, Levy, Zerfas, Moran, Lee, Bequette, Diaz: "Acute metabolic decompensation due to influenza in a mouse model of ornithine transcarbamylase deficiency." in: Disease models & mechanisms, Vol. 7, Issue 2, pp. 205-13, (2014) (PubMed).

Yoon, Ling, Isik, Lee, Steinbaugh, Sack, Boduch, Blackwell, Sinclair, Elledge: "GLTSCR2/PICT1 links mitochondrial stress and Myc signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 10, pp. 3781-6, (2014) (PubMed).

Hallows, Yu, Smith, Devries, Devires, Ellinger, Someya, Shortreed, Prolla, Markley, Smith, Zhao, Guan, Denu: "Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction." in: Molecular cell, Vol. 41, Issue 2, pp. 139-49, (2011) (PubMed).

Wu, Hsu, Chen, Yu, Chang, Tai, Liu, Su, Chang, Yu: "Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 6, pp. 1100-17, (2010) (PubMed).

Walters, Wallace: "Urea cycle gene expression is suppressed by PFOA treatment in rats." in: Toxicology letters, Vol. 197, Issue 1, pp. 46-50, (2010) (PubMed).

Yu, Lin, Yao, Huang, Lei, Xiong, Zhao, Guan: "Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals." in: The Journal of biological chemistry, Vol. 284, Issue 20, pp. 13669-75, (2009) (PubMed).

Chaerkady, Harsha, Nalli, Gucek, Vivekanandan, Akhtar, Cole, Simmers, Schulick, Singh, Torbenson, Pandey, Thuluvath: "A quantitative proteomic approach for identification of potential biomarkers in hepatocellular carcinoma." in: Journal of proteome research, Vol. 7, Issue 10, pp. 4289-98, (2008) (PubMed).

Montes-Nieto, Fuentes-Almagro, Bonilla-Valverde, Prieto-Alamo, Jurado, Carrascal, Gómez-Ariza, López-Barea, Pueyo: "Proteomics in free-living Mus spretus to monitor terrestrial ecosystems." in: Proteomics, Vol. 7, Issue 23, pp. 4376-87, (2007) (PubMed).

Tanaka, Wada, Maruyama, Tanaka, Takikawa, Komatsu: "Hyperammonemia-induced encephalopathy due to ornithine transcarbamylase deficiency in an adult woman: identification of novel missense mutations." in: Journal of gastroenterology, Vol. 40, Issue 1, pp. 106-7, (2005) (PubMed).

Synonyms and alternative names related to OTC

ornithine carbamoyltransferase (OTC), plexin A2 (Plxna2), ornithine carbamoyltransferase (Otc), ornithine carbamoyltransferase (argF), ornithine carbamoyltransferase ArgF (argF), ornithine carbamoyltransferase (argF-2), ornithine carbamoyltransferase (atpD-2), ornithine carbamoyltransferase (CNC04300), plexin A2 (PLXNA2), ornithine transcarbamylase (Otc), ornithine carbamoyltransferase (otc), 2810428A13Rik, AA589422, AI265390, AW457381, BA4351, F1B16.13, F1B16_13, mKIAA0463, OCT, OCTD, ORNITHINE CARBAMOYLTRANSFERASE, ornithine carbamoyltransferase, Plxn2, PLXN2, PSPTO4164, Sf, si:dkey-19h21.3, spf

Protein level used designations for OTC

  • OTCase
  • ornithine carbamoyltransferase, mitochondrial
  • ornithine transcarbamylase
  • plex 2
  • plexin 2
  • plexin-2
  • plexin-A2
  • ornithine carbamoyltransferase
  • semaphorin receptor OCT
  • transmembrane protein OCT
  • sparse fur
  • LOW QUALITY PROTEIN: ornithine carbamoyltransferase, mitochondrial
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