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PAI1 Proteins

(Plasminogen Activator Inhibitor 1 (SERPINE1))
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

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  • Target: PAI1 (SERPINE1)
  • Protein
Catalog no. Product Reactivity Host / Clonality Application Price & lead time
ABIN7959625
PAI1 Protein (His tag) SERPINE1 · Protein Human Human Cells
$851.40 View price
  • 50 μg
  • 1 mg
  • 500 μg
Delivery in 8 to 12 Business Days Shipping to: United States
ABIN7960287
PAI1 Protein (His tag) SERPINE1 · Protein Mouse Human Cells
$851.40 View price
  • 50 μg
  • 1 mg
  • 500 μg
Delivery in 8 to 12 Business Days Shipping to: United States
ABIN6382091
PAI1 Protein (His tag) SERPINE1 · Protein Monkey Escherichia coli (E. coli)
  • WB (Western Blotting: Listed application)
  • SDS (SDS-PAGE: Listed application)
$2,721.06 View price
  • 1 mg
  • 50 μg
  • 100 μg
  • 200 μg
  • 500 μg
Delivery in 10 to 20 Business Days Shipping to: United States
ABIN6125444
PAI1 Protein (His tag) SERPINE1 · Protein Rabbit Escherichia coli (E. coli)
  • WB (Western Blotting: Listed application)
  • SDS (SDS-PAGE: Listed application)
$580.46 View price
  • 50 μg
  • 1 mg
  • 100 μg
  • 200 μg
  • 500 μg
Delivery in 10 to 20 Business Days Shipping to: United States
ABIN2731825
PAI1 Protein (Transcript Variant 1) (His tag) SERPINE1 · Protein Human HEK-293 Cells
  • AbP (Antibody Production: Listed application)
  • STD (Standard: Listed application)
$480.00 View price
  • 10 μg
Delivery in 4 to 9 Business Days Shipping to: United States
Protein
Origin
Human
Host
Human Cells
Protein Type
Recombinant
Purity
Greater than 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7959625
$851.40
Plus shipping costs $50.00
50 μg (More quantities available)
Shipping to: United States
Delivery in 8 to 12 Business Days
Protein
Origin
Mouse
Host
Human Cells
Protein Type
Recombinant
Purity
Greater than 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7960287
$851.40
Plus shipping costs $50.00
50 μg (More quantities available)
Shipping to: United States
Delivery in 8 to 12 Business Days
Protein
  • WB (Western Blotting: Listed application)
  • SDS (SDS-PAGE: Listed application)
Origin
Monkey
Host
Escherichia coli (E. coli)
Protein Type
Recombinant
Purity
> 95 %
Catalog No. ABIN6382091
$2,721.06
Plus shipping costs $50.00
1 mg (More quantities available)
Shipping to: United States
Delivery in 10 to 20 Business Days
Protein
  • WB (Western Blotting: Listed application)
  • SDS (SDS-PAGE: Listed application)
Origin
Rabbit
Host
Escherichia coli (E. coli)
Protein Type
Recombinant
Purity
> 90 %
Catalog No. ABIN6125444
$580.46
Plus shipping costs $50.00
50 μg (More quantities available)
Shipping to: United States
Delivery in 10 to 20 Business Days
Protein
  • AbP (Antibody Production: Listed application)
  • STD (Standard: Listed application)
Origin
Human
Host
HEK-293 Cells
Protein Type
Recombinant
Purity
> 95 % as determined by SDS-PAGE and Coomassie blue staining
Catalog No. ABIN2731825
$480.00
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to: United States
Delivery in 4 to 9 Business Days

Latest Publications for our PAI1 Proteins

Reichel, Hessenauer, Pflieger, Rehberg, Kanse, Zahler, Krombach, Berghaus, Strieth: "Components of the Plasminogen Activation System Promote Engraftment of Porous Polyethylene Biomaterial via Common and Distinct Effects." in: PLoS ONE, Vol. 10, Issue 2, pp. e0116883, (2015) (PubMed).

Florova, Azghani, Karandashova, Schaefer, Koenig, Stewart-Evans, Declerck, Idell, Komissarov: "Targeting of plasminogen activator inhibitor 1 improves fibrinolytic therapy for tetracycline-induced pleural injury in rabbits." in: American journal of respiratory cell and molecular biology, Vol. 52, Issue 4, pp. 429-37, (2015) (PubMed).

Dinarvand, Hassanian, Weiler, Rezaie: "Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation." in: Blood, Vol. 125, Issue 8, pp. 1339-48, (2015) (PubMed).

Simone, Higgins, Archambeault, Higgins, Ginnan, Singer, Higgins: "A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage." in: Cellular signalling, Vol. 27, Issue 5, pp. 923-33, (2015) (PubMed).

Yang, Kuan: "Anti-tissue plasminogen activator (tPA) as an effective therapy of neonatal hypoxia-ischemia with and without inflammation." in: CNS neuroscience & therapeutics, Vol. 21, Issue 4, pp. 367-73, (2015) (PubMed).

Komissarov, Florova, Azghani, Buchanan, Bradley, Schaefer, Koenig, Idell: "The time course of resolution of adhesions during fibrinolyitic therapy in tetracycline-induced pleural injury in rabbits." in: American journal of physiology. Lung cellular and molecular physiology, pp. ajplung.00136.2015, (2015) (PubMed).

Damare, Brandal, Fortenberry: "Inhibition of PAI-1 antiproteolytic activity against tPA by RNA aptamers." in: Nucleic acid therapeutics, Vol. 24, Issue 4, pp. 239-49, (2014) (PubMed).

Wan, Gao, Zhou, Zhang, Hao, Lian, Li, Chen, Liu: "SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence." in: Aging cell, Vol. 13, Issue 5, pp. 890-9, (2014) (PubMed).

Florova, Karandashova, Declerck, Idell, Komissarov: "Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex." in: Biochemistry, Vol. 52, Issue 27, pp. 4697-709, (2013) (PubMed).

Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: "Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 305, Issue 10, pp. L682-92, (2013) (PubMed).

Aliases for PAI1 Proteins

serpin family E member 1 (SERPINE1) Proteins
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 L homeolog (serpine1.L) Proteins
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (serpine1) Proteins
serine (or cysteine) peptidase inhibitor, clade E, member 1 (Serpine1) Proteins
serpin family E member 1 (Serpine1) Proteins
PAI Proteins
PAI-1 Proteins
PAI1 Proteins
Pai1 Proteins
PAI1A Proteins
Pai1aa Proteins
Planh Proteins
PLANH1 Proteins
Planh1 Proteins
RATPAI1A Proteins
SERPINE1 Proteins
si:ch211-138a11.1 Proteins
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