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Human p300 Protein expressed in Insect cells (Sf9) - ABIN2720219
Martinez, Abe, Hong, Molyneux, Yarnell, Löhr, Driever, Acosta, Arcos-Burgos, Muenke: An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility. in Biological psychiatry 2016
E-cadherin (show CDH1 Proteins) expression was increased by transfection of p300 small interfering RNA in a dose-dependent manner.. There was a correlation between Snail (show SNAI1 Proteins) and p300 expressions in lung cancer. Moreover, p300 acetylates Snail (show SNAI1 Proteins) both in vivo and in vitro, and K187 may be involved in this modification.
Two possible modes of pioneering associated with combinations of H2A.Z (show H2AFZ Proteins) and p300/CBP (show CREBBP Proteins) at nucleosome-occupied enhancers.
these results demonstrate that the reversible acetylation of FOXM1 (show FOXM1 Proteins) by p300/CBP (show CREBBP Proteins) and SIRT1 (show SIRT1 Proteins) modulates its transactivation function
Ectopic expression of EP300-ZNF384 (show ZNF384 Proteins) and CREBBP (show CREBBP Proteins)-ZNF384 (show ZNF384 Proteins) fusion altered differentiation of mouse hematopoietic stem and progenitor cells and also potentiated oncogenic transformation in vitro.our results indicate that gene fusion is a common class of genomic abnormalities in childhood ALL and that recurrent translocations involving EP300 and CREBBP (show CREBBP Proteins) may cause epigenetic deregulation with potential for therapeutic targeting.
p300 inhibition attenuates both thrombin (show F2 Proteins) induced-CCL2 (show CCL2 Proteins) expression and histone H3 (show HIST3H3 Proteins) and H4 acetylation in HLFs, suggesting that p300 is involved in thrombin (show F2 Proteins)-induced CCL2 (show CCL2 Proteins) expression via hyperacetylating histone H3 (show HIST3H3 Proteins) and H4.
p300-dependent histone H3 (show HIST3H3 Proteins) acetylation and C/EBPbeta (show CEBPB Proteins)-regulated IKKbeta (show IKBKB Proteins) expression contribute to thrombin (show F2 Proteins)-induced IL-8/CXCL8 (show IL8 Proteins) expression in human lung epithelial cells.
MnTE-2-PyP (show PPA1 Proteins) decreased p300 complex binding to a specific HRE motif within the PAI-1 (show SERPINE1 Proteins) gene promoter region, suppressed H3K9 acetylation, and consequently, repressed PAI-1 (show SERPINE1 Proteins) expression. Mechanistically, less p300 transcriptional complex binding is not due to the reduction of binding between p300 and HIF-1 (show HIF1A Proteins)/CREB (show CREB1 Proteins) transcription factors, but through inhibiting the binding of HIF-1 (show HIF1A Proteins)/CREB (show CREB1 Proteins) transcription factors to DNA
High p300 expression is associated with prostate cancer growth.
Understanding the effects of disrupting the acetyltransferase activity of CBP/p300 (show CREBBP Proteins) could pave the way for new therapeutic approaches to treat patients with these diseases
How cancer cells use p300/CBP (show CREBBP Proteins) in their favor varies depending on the cellular context and is evident by the growing list of loss- and gain-of-function genetic alterations in p300 and CBP (show CREBBP Proteins) in solid tumors and hematological malignancies.[review]
Here the authors report a lipopolysaccharide-induced NFkappaB enhanceosome in which TonEBP (show NFAT5 Proteins) is required for the recruitment of p300 (show NOTCH1 Proteins). Increased expression of TonEBP (show NFAT5 Proteins) enhances the NFkappaB activity and reduced TonEBP (show NFAT5 Proteins) expression lowers it.
Enhancer-priming by MLL3/MLL4 followed by enhancer-activation by CBP/p300 (show CREBBP Proteins) sequentially shape dynamic enhancer landscapes during cell differentiation
Data show that LPS (show TLR4 Proteins) induces endoplasmic reticulum (ER) stress and P300 (show NOTCH1 Proteins) activity via the XBP1 (show XBP1 Proteins)/IRE1 (show ERN1 Proteins) pathway.
Loss of p300 (show NOTCH1 Proteins) expression is associated with leukemogenesis.
UTX (show KDM6A Proteins)-MLL4-p300 (show NOTCH1 Proteins) transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (show CREBBP Proteins) and HDAC1-HDAC2 (show HDAC1 Proteins) has been described.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 (show PRMT1 Proteins) activity was necessary for c-Myc (show MYC Proteins) binding to acetyltransferase p300 (show NOTCH1 Proteins) in myeloid cells; Prmt1 (show PRMT1 Proteins) inhibition decreases p300 (show NOTCH1 Proteins) recruitment to c-Myc (show MYC Proteins) target promoters and increased Hdac1 (show HDAC1 Proteins) recruitment. [Prmt1 (show PRMT1 Proteins), protein arginine N-methyltransferase 1 (show PRMT1 Proteins); c-Myc (show MYC Proteins) = Proto-Oncogene (show RAB1A Proteins) Proteins c-myc (show MYC Proteins); Hdac1 (show HDAC1 Proteins) = histone deacetylase 1 (show HDAC1 Proteins)]
In line with the acetyltransferase activity of p300 (show NOTCH1 Proteins), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (show HDAC3 Proteins) activity maintains PTGES1 expression by recruiting p300 (show NOTCH1 Proteins) to its gene
ARX positively regulates Wnt (show WNT2 Proteins)/ beta-catenin (show CTNNB1 Proteins) signaling and the C-terminal domain of ARX interacts with the armadillo (show PKP1 Proteins) repeats in beta-catenin (show CTNNB1 Proteins) to promote Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling. In addition, we found BCL9 (show BCL9 Proteins) and P300 (show NOTCH1 Proteins) also interact with ARX to modulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
2-O, 3-O desulfated heparin inhibited HMGB1 (show HMGB1 Proteins) release, at least in part, by direct molecular inhibition of p300 HAT activity.
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
histone acetyltransferase p300
, histone acetyltransferase
, E1A binding protein p300
, histone acetyltransferase p300-like
, E1A-associated protein p300
, E1A-binding protein, 300kD
, p300 HAT