(Protein Disulfide Isomerase Family A, Member 3 (PDIA3))
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase\; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008].
Koivunen, Helaakoski, Annunen, Veijola, Räisänen, Pihlajaniemi, Kivirikko: "ERp60 does not substitute for protein disulphide isomerase as the beta-subunit of prolyl 4-hydroxylase." in: The Biochemical journal, Vol. 316 ( Pt 2), pp. 599-605, (1996) (PubMed).
Bourdi, Demady, Martin, Jabbour, Martin, George, Pohl: "cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase." in: Archives of biochemistry and biophysics, Vol. 323, Issue 2, pp. 397-403, (1995) (PubMed).
Hirano, Shibasaki, Kato, Sakai, Tanaka, Nishida, Yazaki, Takenawa, Hirai: "Molecular cloning and characterization of a cDNA for bovine phospholipase C-alpha: proposal of redesignation of phospholipase C-alpha." in: Biochemical and biophysical research communications, Vol. 204, Issue 1, pp. 375-82, (1994) (PubMed).
Aliases for PDIA3 Proteins
protein disulfide isomerase family A member 3 (PDIA3) Proteins protein disulfide-isomerase A3 (Tsp_10062) Proteins protein disulfide isomerase associated 3 (Pdia3) Proteins protein disulfide isomerase family A, member 3 (Pdia3) Proteins protein disulfide isomerase family A member 3 (Pdia3) Proteins protein disulfide isomerase family A, member 3 (pdia3) Proteins protein disulfide isomerase family A member 3 S homeolog (pdia3.S) Proteins 1 Proteins 25D3-membrane-associated Proteins 58kDa Proteins ER60 Proteins Erp Proteins ERp57 Proteins erp57 Proteins ERp60 Proteins ERp61 Proteins grp-58 Proteins GRP57 Proteins GRP58 Proteins Grp58 Proteins grp58 Proteins HsT17083 Proteins P58 Proteins PDI Proteins PDI-Q2 Proteins pdia3 Proteins PI-PLC Proteins Plca Proteins PLC[a] Proteins sb:cb825 Proteins