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Bone Morphogenetic Protein 10 (BMP10) (C-Term) Peptide

BMP10 Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN2183892
  • Target See all BMP10 products
    BMP10 (Bone Morphogenetic Protein 10 (BMP10))
    Protein Region
    C-Term
    Origin
    Human
    Source
    • 4
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Sequence
    GYEAYECRGV CNYPLAEHLT PTKHAIIQAL VHLKNSQKAS KACCVPTKLE
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-BMP10 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeat freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    BMP10 (Bone Morphogenetic Protein 10 (BMP10))
    Synonyms
    BMP10 Peptide, si:dkey-13n15.5 Peptide, Bmp10 Peptide, BMP9 Peptide, BMP-10 Peptide, bone morphogenetic protein 10 Peptide, BMP10 Peptide, bmp10 Peptide, LOC662386 Peptide, Bmp10 Peptide
    Background
    BMP10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.

    Alias Symbols: -

    Protein Size: 424
    Molecular Weight
    46 kDa
    Gene ID
    27302
    NCBI Accession
    NM_014482, NP_055297
    UniProt
    O95393
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