Bone Morphogenetic Protein 10 (BMP10) (C-Term) Peptide
BMP10
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN2183892
$160.46
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100 μg
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Quick Overview for Bone Morphogenetic Protein 10 (BMP10) (C-Term) Peptide (ABIN2183892)
Target
BMP10
(Bone Morphogenetic Protein 10 (BMP10))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- GYEAYECRGV CNYPLAEHLT PTKHAIIQAL VHLKNSQKAS KACCVPTKLE
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-BMP10 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeat freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- BMP10 (Bone Morphogenetic Protein 10 (BMP10))
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Background
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BMP10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.
Alias Symbols: -
Protein Size: 424 -
Molecular Weight
- 46 kDa
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Gene ID
- 27302
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NCBI Accession
- NM_014482, NP_055297
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UniProt
- O95393
Target
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