Bone Morphogenetic Protein 10 (BMP10) (N-Term) Peptide
BMP10
Reactivity: Rat
Host: Synthetic
BP, WB
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- Target See all BMP10 products
- BMP10 (Bone Morphogenetic Protein 10 (BMP10))
- Protein Region
- N-Term
- Origin
- Rat
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KFATDRTSMP SANIIRSFKN EDLFSQPVSF NGIRKYPLLF NVSIPHHEEV
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Bmp10 Antibody(ARP47031_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- BMP10 (Bone Morphogenetic Protein 10 (BMP10))
- Synonyms
- BMP10 Peptide, si:dkey-13n15.5 Peptide, Bmp10 Peptide, BMP9 Peptide, BMP-10 Peptide, bone morphogenetic protein 10 Peptide, BMP10 Peptide, bmp10 Peptide, LOC662386 Peptide, Bmp10 Peptide
- Background
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Bmp10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Bmp10 acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Bmp10 inhibits endothelial cell migration and growth.
Alias Symbols: Bmp10
Protein Size: 421 - Molecular Weight
- 48 kDa
- Gene ID
- 500245
- NCBI Accession
- NM_001031824, NP_001026994
- UniProt
- Q4AEG6
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