Insulin Induced Gene 1 (INSIG1) (Middle Region) Peptide
INSIG1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5513077
Quick Overview for Insulin Induced Gene 1 (INSIG1) (Middle Region) Peptide (ABIN5513077)
Target
INSIG1
(Insulin Induced Gene 1 (INSIG1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- LAAHGAPDAD PAPRGRSAAM SGPEPGSPYP NTWHHRLLQR SLVLFSVGVV
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-INSIG1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- INSIG1 (Insulin Induced Gene 1 (INSIG1))
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Background
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Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: CL6, CL-6
Protein Size: 277 -
Gene ID
- 3638
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NCBI Accession
- NM_005542, NP_005533
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UniProt
- O15503
Target
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