Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (Middle Region) Peptide
POLR3C
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5673454
$160.46
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100 μg
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Quick Overview for Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (Middle Region) Peptide (ABIN5673454)
Target
POLR3C
(Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- VPKLSLIGKG KRRRSSDEDA AGEPKAKRPK YTTDNKEPIP DDGIYWQANL
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- POLR3C Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
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Background
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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Alias Symbols: RPC3, RPC62
Protein Size: 534 -
Gene ID
- 10623
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NCBI Accession
- NM_001303456, NP_001290385
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UniProt
- Q9BUI4
Target
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