Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (Middle Region) Peptide
POLR3C
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN981969
$160.46
Plus shipping costs $50.00
100 μg
Shipping to:
United States
Delivery in 11 to 17 Business Days
Quick Overview for Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (Middle Region) Peptide (ABIN981969)
Target
POLR3C
(Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- Middle Region
-
Sequence
- VEAIIASMQA TGAEEAQLQE IEEMITAPER QQLETLKRNV NKLDASEIQV
-
Characteristics
- This is a synthetic peptide designed for use in combination with anti-POLR3C Antibody(ARP52190_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Purification
- Purified
-
-
-
-
Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Concentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handling Advice
- Avoid repeated freeze-thaw cycles.
-
Storage
- -20 °C
-
Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
-
Background
-
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3C is a specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. POLR3C may direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. POLR3C may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.POLR3C acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3C can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Alias Symbols: RPC3, RPC62
Protein Interaction Partner: GTF3C4,GTF3C1,GTF3C2,GTF3C3,GTF3C4,GTF3C5,POLR3D,POLR3F,POLR3G,POLR3H,TBP
Protein Size: 534 -
Molecular Weight
- 60 kDa
-
Gene ID
- 10623
-
NCBI Accession
- NM_006468, NP_006459
-
UniProt
- Q9BUI4
Target
-
You are here:
