Catalog No. ABIN7821927
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Quick Overview for alpha-conotoxin IMI Peptide (ABIN7821927)
Target
alpha-conotoxin IMI
Origin
Conus imperialis
Source
Synthetic
Application
Blocking Peptide (BP)
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Peptide Type
- Synthetic
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Purpose
- A Potent Antagonist of Mammalian α3/β2 Neuronal nAChR
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Sequence
- GCCSDPRCAW RC-NH2
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Specificity
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Toxin target: α3/β2 nAChR,
Disulfide bonds between: Cys2-Cys8 and Cys3-Cys12 Cys12 - C-terminal amidation -
Characteristics
- A Potent Antagonist of Mammalian α3/β2 Neuronal nAChR
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Purity
- ≥99 % (HPLC)
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alpha-conotoxin IMI peptide (Atto 590)
Reactivity: Conus imperialis Host: Synthetic BP, FM, IF, LCI
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Application Notes
- Antigen Preadsorption Control: 0.1 - 10 μM
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing, light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 μM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
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Buffer
- Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
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Storage
- 4 °C,-20 °C
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Storage Comment
- The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.,The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
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- alpha-conotoxin IMI
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Background
- α-CTx ImI,α-Conotoxin ImI is a 12 amino acid peptidyl toxin isolated from Conus Imperialis venom1, which blocks mammalian neuronal nAChRs located on postsynaptic membranes. This toxin inhibits mammalian neuronal nAChRs (α3/β2 > α7 > α3/β4) in a voltage-independent manner and has no effect on nAChRs composed of α2/β2, α3/β2, α4/β2, α2/β4, α3/β4, or α4/β4 subunits1,2.
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Molecular Weight
- 1351 Da
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UniProt
- P50983
Target
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