ATX-II Peptide
Reactivity: Anemonia sulcata
Host: Synthetic
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Catalog No. ABIN7887375
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Quick Overview for ATX-II Peptide (ABIN7887375)
Target
ATX-II
Origin
Anemonia sulcata
Source
Synthetic
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Peptide Type
- Synthetic
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Biological Activity
- Active
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Purpose
- ATX-II
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Sequence
- GVPCLCDSDG PSVRGNTLSG IIWLAGCPSG WHNCKKHGPT IGWCCKQ-OH
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Specificity
- Toxin target: NaV1.1-1.7 voltage-gated sodium channels
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Purity
- ≥98 % (HPLC)
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Biological Activity Comment
- ATX-II potently modulates voltage-gated Na+ channel gating kinetics by delaying its inactivation and prolonging the action potential of excitable membranes. ATX-II has been used as a powerful activator of TTX-sensitive and insensitive Na+ channels in various excitable tissue and cell types1-9.
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ATX-II peptide (Atto 647N)
Reactivity: Anemonia sulcata Host: Synthetic FACS, FM, IF, LCI
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Application Notes
- Antigen Preadsorption Control: 10 - 100 nM
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Comment
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Electrophysiology
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the vial at 10,000 x g for 5 minutes before opening to ensure all material is collected at the bottom. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial and dissolve by gently tapping, tilting, or rolling the vial. Avoid vigorous vortexing, a brief, light vortex of 1-2 seconds is acceptable if necessary. The product is readily soluble in high-quality pure water at micromolar to millimolar concentrations (typically 100 μM to 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x the final working concentration. Divide the stock solution into small, single-use aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh working solutions just before use. Avoid multiple freeze-thaw cycles to maintain optimal biological activity.
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Buffer
- Lyophilized from double distilled water (ddH2O). May contain residual trifluoroacetate (TFA).
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Handling Advice
- Centrifuge the vial at 10,000 x g for 5 minutes before opening to ensure all material is collected at the bottom,Avoid multiple freeze-thaw cycles to maintain optimal biological activity,Avoid vigorous vortexing. protect from moisture
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Storage
- -20 °C
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Storage Comment
- The product is shipped as a lyophilized powder at room temperature. Upon receipt, store at -20°C and protect from moisture.
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- ATX-II
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Background
- A potent activator of voltage-gated sodium NaV channels that primarily targets cardiac NaV1.5 channels by delaying their fast inactivation
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Molecular Weight
- 4935 Da
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UniProt
- P01528
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CAS-No
- 60748-45-0
Target
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