Death-Domain Associated Protein (DAXX) (N-Term) Peptide
Quick Overview for Death-Domain Associated Protein (DAXX) (N-Term) Peptide (ABIN8098693)
Target
Origin
Source
Application
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Protein Region
- N-Term
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Purpose
- DAXX Peptide - N-terminal region
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Sequence
- KLNLAPAATT SNEPSGNNPP THLSLDPTNA ENTASQSPRT RGSRRQIQRL
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-DAXX Antibody (ARP60159_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- DAXX (Death-Domain Associated Protein (DAXX))
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Background
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Background Information: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
Alternative Symbols: Name=DAXX,
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Molecular Weight
- 81kDa
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Gene ID
- 1616
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NCBI Accession
- NP_001341
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UniProt
- Q9UER7
Target
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