High Mobility Group Box 3 (HMGB3) (Middle Region) Peptide
Quick Overview for High Mobility Group Box 3 (HMGB3) (Middle Region) Peptide (ABIN8102519)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- HMGB3 Peptide - middle region
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Sequence
- VRYDREMKDY GPAKGGKKKK DPNAPKRPPS GFFLFCSEFR PKIKSTNPGI
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- HMGB3 Antibody (ARP90696_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- HMGB3 (High Mobility Group Box 3 (HMGB3))
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Background
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Background Information: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling.
Alternative Symbols: Hmg4, Hmg2a
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Molecular Weight
- 23 kDa
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Gene ID
- 15354
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NCBI Accession
- NP_001280552
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UniProt
- O54879
Target
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